High recovery rates and relatively low standard deviations were found in the applied methods and recommended for use in the pharmaceutical industry.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, the NIR and UV-Vis spectroscopy methods, which are frequently used in pharmaceutical industry, were applied to the environments where Paracetamol, Propyphenazone and Caffeine active substances are present, and the spectroscopic data obtained were evaluated comparatively with ICA-ANN and PLS-1, which are powerful chemometric methods.
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Key Findings & Data:Following the application of both methods, spectral data were evaluated as chemometrics and in both spectroscopic methods ICA-ANN method yielded more accurate results than PLS-1.
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Conclusion & Impact:High recovery rates and relatively low standard deviations were found in the applied methods and recommended for use in the pharmaceutical industry.
In this study, the NIR and UV-Vis spectroscopy methods, which are frequently used in pharmaceutical industry, were applied to the environments where Paracetamol, Propyphenazone and Caffeine active substances are present, and the spectroscopic data obtained were evaluated comparatively with ICA-ANN and PLS-1, which are powerful chemometric methods. When using solid agents in NIR method, liquid solutions equivalent to them were used in UV-Vis method. Following the application of both methods, spectral data were evaluated as chemometrics and in both spectroscopic methods ICA-ANN method yielded more accurate results than PLS-1. High recovery rates and relatively low standard deviations were found in the applied methods and recommended for use in the pharmaceutical industry.
AKTAŞ, A. H., ŞAHİN, H. O. (2021). A speedy method for simultaneous determination in tablet active content by NIR and UV-Vis spectrophotometry: Comparison of PLS-1 and ICA-ANN models. Gazi University Journal of Science, Cilt: 34 - Sayı: 2, 370–379. https://ajindex.com/articles/254350
The Indian Pharmacopoeia, Controller of Publications, New Delhi; 953, (2010)
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