SavedAdd your journal

Journals / Communications Faculty of Sciences University of Ankara Series C Biology / 2019 / Cilt: 28 - Sayı: 2

SYNTHESIS OF OPEN-CHAIN SUGAR DERIVATIVES AS ANTICANCER AND ANTIMICROBIAL AGENTS

İdris YAZGAN
Pages
148–159
Publication Date
2019-12-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The findings showed that carbohydrate residue along with substituted group play the major role for the observed activity of the carbohydrate ligands.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Öz In the present study, three sugar residues including mannose, galactose and lactose were modified with organic substituents via reductive amination reaction in order to get strong anticancer carbohydrate derivatives for A549 cell line and antibacterial agents targeting E.coli and S.epidermidis.
📊
Key Findings & Data:Öz In the present study, three sugar residues including mannose, galactose and lactose were modified with organic substituents via reductive amination reaction in order to get strong anticancer carbohydrate derivatives for A549 cell line and antibacterial agents targeting E.coli and S.epidermidis.
💡
Conclusion & Impact:The findings showed that carbohydrate residue along with substituted group play the major role for the observed activity of the carbohydrate ligands.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar Kelimeler Carbohydrate derivatives · lectins · Anticancer

Özet

Öz In the present study, three sugar residues including mannose, galactose and lactose were modified with organic substituents via reductive amination reaction in order to get strong anticancer carbohydrate derivatives for A549 cell line and antibacterial agents targeting E.coli and S.epidermidis. The findings showed that carbohydrate residue along with substituted group play the major role for the observed activity of the carbohydrate ligands.

🔖

Cite This Article

YAZGAN, İ. (2019). SYNTHESIS OF OPEN-CHAIN SUGAR DERIVATIVES AS ANTICANCER AND ANTIMICROBIAL AGENTS. Communications Faculty of Sciences University of Ankara Series C Biology, Cilt: 28 - Sayı: 2, 148–159. https://ajindex.com/articles/247840

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Gabius H (2018). The sugar code: Why glycans are so important. Biosystems 164: 102–111.
  2. Zhang Y, Chan JW, Moretti A, Uhrich KE (2015). Designing polymers with sugar-based advantages for bioactive delivery applications. Journal of Controlled Release 219: 355–368.
  3. Drickamer K, Taylor ME (2015). Recent insights into structures and functions of C-type lectins in the immune system. Current Opinion in Structural Biology 34: 26–34.
  4. Schwardt O, Rabbani S, Hartmann M, Abgottspon D, Wittwer M, Kleeb S, Zalewski A, Smieško M, Cutting B, Ernst B (2011). Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists. Bioorganic Medicinal Chemistry 19: 6454–6473.
  5. Sippelli S (2016). New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor. Bioorganic Medicinal Chemistry Letters 26: 636–639.
  6. Fokt I, Szymanski S, Skora S, Cybulski M, Madden T, Priebe W (2009). D -Glucose- and D -mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo- D -glucoses and - D -mannoses. Carbohydrate Research 344: 1464–1473.
  7. Lian S, Su H, Zhao B, Liu W, Zheng L, Miao J (2009). Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells. Bioorganic Medicinal Chemistry 17: 7085–7092. Hajdúch M, Petruš L. Synthesis and cytotoxicity of some D -mannose click conjugates with aminobenzoic acid derivatives. Carbohydrate Research, 361: 1–6.
  8. Yazgan I (2016). Novel Poly (amic) Acid Membrane Chemistries with Experimentally-controlled Pore size, Transport and Disinfection Properties, State University of New York at Binghamton. Stokmaier D, Khorev O, Cutting B, Born R, Ricklin D, Ernst TOG, Böni F, Schwingruber K, Gentner M, Wittwer M, Spreafico M, Vedani A, Rabbani S, Schwardt O, Ernst B (2009). Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor ( ASGP-R ). Bioorganic Medicinal Chemistry 17: 7254–7264.
  9. Ahmed T, Shahid M, Azeem F, I. Rasul, Shah AA, Noman M, Hameed A, Manzoor N, Manzoor I, Muhammad S (2018). Biodegradation of plastics: current scenario and future prospects for environmental safety. Environmental Science and Pollution Research 25(8): 7287-7298.
  10. Alsalahy MM, Almehy GF, Hendy RM, Mohammad RS, Mahmoud Y (2017). Mannose binding lectin in patients with pulmonary tuberculosis: Active and inactive. The Egyptian Journal of Chest Diseases and Tuberculosis 66: 413–418.
  11. Naguib MM, Al MM, Al GF, El MM (2015). Study of mannose-b