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Journals / Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2019 / Cilt: 12 - Sayı: 1

Voltammetric Determination of Metamizol Sodium in Pharmaceutical Tablets at Polypyrrole-Carbon Nanotube Modified Electrodes

Poliprol-Karbon Nanotüp Modifiye Elektrotta Farmasötik Tabletlerde Metamizol Sodyumun Voltammetrik Tayini

Volkan ÖZDOKUR
Çağrı Ceylan KOÇAK
Pages
317–325
Publication Date
2019-03-24
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall results showed that PPy-CNT electrode has an excellent sensitivity, selectivity and anti-fouling properties for the voltammetric determination of metamizol.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Poly pyrrole-carbon nanotube (PPy-CNT) composite electrodes were prepared with ultrasonication assisted pulsed polymerization technique.
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Key Findings & Data:Resulted electrode was characterized by scanning electron microscopy and used for investigation of metamizaol in pH:2 Britton-Robinson buffer solution.
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Conclusion & Impact:The overall results showed that PPy-CNT electrode has an excellent sensitivity, selectivity and anti-fouling properties for the voltammetric determination of metamizol.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:PPy-CNT · Metamizol Sodyum · voltammetry

Abstract

Poly pyrrole-carbon nanotube (PPy-CNT) composite electrodes were prepared with ultrasonication assisted pulsed polymerization technique. This technique possesses both advantages of ultrasonication and electrochemical polymerization. PPy-CNT composite was modified on the bare glassy carbon electrode (GCE) surface easily with pulsed deposition technique that provide more catalytically active surface compared to the bare GCE towards metamizol oxidation. Resulted electrode was characterized by scanning electron microscopy and used for investigation of metamizaol in pH:2 Britton-Robinson buffer solution. In the differential pulse voltammetric determination, the linear range was found as 5-500 mg L-1 with a detection limit of 1.6 mg L-1 . The overall results showed that PPy-CNT electrode has an excellent sensitivity, selectivity and anti-fouling properties for the voltammetric determination of metamizol. PPy-CNT/GCE sensor was applied succesfully to the determination of metamizol in novalgine sample.

Özet

Polipirol-karbon nanotüp (PPy-CNT) kompozit elektrot, ultrasonikasyon ile eşleştirilmiş pulslu polimerizasyon tekniği ile hazırlanmıştır. Bu teknik, hem ultrasonikasyon hem de elektrokimyasal polimerizasyonun avantajlarına sahiptir. PPy-CNT kompoziti pulslu depolama tekniği ile camımsı karbon elektrot (GCE) yüzeyine kolayca modifiye edilmiş, ve metamizol yükseltgenmesine karşı camımsı karbon elektroda göre katalitik aktivitesi yüksek bir yüzey elde edilmiştir. Hazırlanan elektrot taramalı electron mikroskopu ile karakterize edilmiş ve pH:2 Britton-Robinson tamponunda metamizol davranışı incelenmiştir. Diferansiyel pulse voltammetrisi ile lineer aralık 5-500 mg L-1 olarak saptanmış ve belirtme alt sınırı1.6 mg L-1 olarak hesaplanmıştır. Yapılan tüm çalışmalar göstermiştir ki, PPY-CNT/GCE, metamizol tayini için yüksek duyarlılık, seçimlilik ve kararlılığa sahiptir. PPy-CNT/GCE sensörü novalgine tablet örneğine uygulanarak gerçek örnek analizi başarı ile gerçekleştirilmiştir.

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Cite This Article

ÖZDOKUR, V., KOÇAK, Ç. C. (2019). Voltammetric Determination of Metamizol Sodium in Pharmaceutical Tablets at Polypyrrole-Carbon Nanotube Modified Electrodes. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 12 - Sayı: 1, 317–325. https://ajindex.com/articles/234092

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