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Journals / Livestock Studies / 2020 / Cilt: 60 - Sayı: 2

Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep

Yalçın YAMAN
Pages
68–73
Publication Date
2021-01-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The genotyping results showed that these SNPs in the DPPA2 and SYTL3 genes are polymorphic.

📌 3 Key Takeaways

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Objective & Hypothesis:Visna/maedi (VM) is an incurable viral disease of sheep causing serious production losses across the globe.
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Key Findings & Data:In this study, we aimed to investigate possible associations between two previously reported single nucleotide polymorphisms (SNPs) in the ovine DPPA2 and SYTL3 genes and VM serostatus, and evaluate implementation of selective breeding strategies against VM in Karacabey merino, Kivircik, Imroz, and composite breeds; Bandirma, Hampshire crosses (HAMP), Ramlic and Black-headed German mutton crosses (SBA) which are reared in Marmara region of Turkey.
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Conclusion & Impact:The genotyping results showed that these SNPs in the DPPA2 and SYTL3 genes are polymorphic.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Visna/maedi · Genetic association · Genetic resistance/susceptibility

Abstract

Visna/maedi (VM) is an incurable viral disease of sheep causing serious production losses across the globe. Classical control measures against VM such as screening and culling are costly and time-consuming. Breeding VM resistant sheep could provide an opportunity for struggling with the VM and decreasing the economic loss. In this study, we aimed to investigate possible associations between two previously reported single nucleotide polymorphisms (SNPs) in the ovine DPPA2 and SYTL3 genes and VM serostatus, and evaluate implementation of selective breeding strategies against VM in Karacabey merino, Kivircik, Imroz, and composite breeds; Bandirma, Hampshire crosses (HAMP), Ramlic and Black-headed German mutton crosses (SBA) which are reared in Marmara region of Turkey. For this purpose, we genotyped the sheep which VM serostatus were determined previously. The genotyping results showed that these SNPs in the DPPA2 and SYTL3 genes are polymorphic. We have conducted an association analysis with an experimental design using case-control matched pairs. Finally, a power analysis was performed to determine the power of the statistical analysis. According to our findings, within our detection limits (the minimum odds ratio 2.5 to 2.8; CI 95; statistical power 0.96; p-value

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Cite This Article

YAMAN, Y. (2021). Evaluation of Two SNP Markers in DPPA2 and SYTL3 Genes for Association with Host Response against Visna/Maedi Infection in Turkish Sheep. Livestock Studies, Cilt: 60 - Sayı: 2, 68–73. https://ajindex.com/articles/228290

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