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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2005 / Cilt: 11 - Sayı: 1

The effect of caffeic acid phenetyl ester on ischemia - reperfusion injury in comparison with resveratrol in rat ovaries

Şeyma HASÇALIK
Önder ÇELİK
YUSUF TÜRKÖZ
YILMAZ ÇİĞREMİŞ
Bülent MIZRAK
Saim YOLOĞLU
Pages
45–48
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

We concluded that these medications would be useful to protect the ovaries from the I/R damage.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTİVE: This experimental study was designed to determine the effects of antioxidants resveratrol and caffeic acid phenetyl ester (CAPE) on nitric oxide (NO) production on an in vivo model of ovarian ischemia-reperfusion in rats.
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Key Findings & Data:RESULTS: NO levels in saline/detorsion group were increased significantly when compared to sham operation and ischemia groups (p<0.05).
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Conclusion & Impact:We concluded that these medications would be useful to protect the ovaries from the I/R damage.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Sıçan · Wistar · Reperfüzyon hasarı

Abstract

OBJECTİVE: This experimental study was designed to determine the effects of antioxidants resveratrol and caffeic acid phenetyl ester (CAPE) on nitric oxide (NO) production on an in vivo model of ovarian ischemia-reperfusion in rats. MATERIAL AND METHOD: Rats were divided into five equal groups each consisting eight rats: sham operation, ischemia-reperfusion (I/R), I/R plus CAPE, I/R plus resveratrol and ischemia groups. CAPE and resveratrol was administered intraperitoneally before reperfusion. After experimental procedure rats were killed, ovaries were removed and prepared for NO concentrations. RESULTS: NO levels in saline/detorsion group were increased significantly when compared to sham operation and ischemia groups (p<0.05). Pretreatment with CAPE and resveratrol significantly attenuated the increase of NO levels in ovarian tissue in comparison to I/R and ischemia groups (p<0.05). In the resveratrol and CAPE groups NO levels were similar. CONCLUSİON: As adnexal torsion could influence further fertility of a young woman, new techniques to protect the ovary from I/R injury had to be improved. CAPE and resveratrol were natural antioxidants. We concluded that these medications would be useful to protect the ovaries from the I/R damage.

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Cite This Article

HASÇALIK, Ş., ÇELİK, Ö., TÜRKÖZ, Y., ÇİĞREMİŞ, Y., MIZRAK, B., YOLOĞLU, S. (2005). The effect of caffeic acid phenetyl ester on ischemia - reperfusion injury in comparison with resveratrol in rat ovaries. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 11 - Sayı: 1, 45–48. https://ajindex.com/articles/227561

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