AI Summary & Key Takeaways
AI InsightThe overall survival rate of the two groups was 38.2%, and was not significantly different between groups (40.9% in the amniocentesis group and 33.3% in the expectant management group; p: 1.00).
📌 3 Key Takeaways
Abstract
OBJECTIVE: To determine whether therapeutic amniocentesis may improve outcomes in patients with twin-twin transfusion syndrome. STUDY DESIGN; Eleven patients were managed aggressively with repetitive serial amniocenteses, and six patients were managed conservatively. RESULTS: The time interval between diagnosis and delivery was 17.4 days more in the amniodrainage group, but the difference between the groups was not significant [68.3±41.9 days in therapeutic amniocentesis group and 50.83±29.7 days in expectant management group (p: 0.384)]. The overall survival rate of the two groups was 38.2%, and was not significantly different between groups (40.9% in the amniocentesis group and 33.3% in the expectant management group; p: 1.00). Two of nine (22.2%) infants in the amnioreduction group, and one of four (25.0%) infants in the expectantly managed group had neurological symptoms. CONCLUSION: Our results did not show a significant benefit of aggressive therapeutic amniocentesis. A slight improvement in perinatal outcome is observed.
Özet
ikiden ikize transfüzyon sendromunda teropotik amniyosentezin prognozu iyileştirip iyileştirmediğini saptamayı amaçladık. Altı hasta konservatif, 11 hasta seri ardışık amnioyosentezler yapılarak takip edildi. Tanı ile doğum arasında geçen süre amniyosentez grubunda 17.4 gün daha fazlaydı ancak bu fark istatistiki olarak anlamlı değildi, [teropotik amniyosentez grubunda 68.3±41.9 gün, konservatif tedavi grubunda 50.83±29.7 gün (p: 0.384)]. Her iki grupta toplam sağ kalım oranı % 38.2 bulundu ve gruplar arasnda sağ kalım oranı a-çısmdan önemli fark saptanmadı (amniyosentez grubunda %40.9, konservatif tedavi grubunda %33.3; p:1.00). Amniyo-sentez grubunda 9 infanttan ikisinde (%22.2), konservatif tedavi grubunda 4 infanttan birinde (%25) nörolojik semptom gelişti. Çalışmamızda agresif teropotik amniyosentezin prognoza önemli katkı sağlamadığını saptadık.