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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2004 / Cilt: 10 - Sayı: 2

The effects of metformin therapy on hyperandrogenism and hyperinsulinemia in women with hirsutism

Fatma H. ALTINTAŞOĞLU
Cüneyt E. TANER
ÜMİT ARSLAN NAYKI
Tolga MIZRAK
Gültekin KOÇUN
Derya DİŞBUDAK
Pages
106–108
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Metformin treatment of women with hirsutism resulted in a decline of insulin and total testosteron levels leading to a significant improvement in hirsutism.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To evaluate the hormonal and clinical effects of metformin therapy in women with hirsutism.
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Key Findings & Data:Twelve weeks of therapy with oral metformin (850 mg two times per day) is applied to twenty eight women with hirsutism.
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Conclusion & Impact:CONCLUSION: Metformin treatment of women with hirsutism resulted in a decline of insulin and total testosteron levels leading to a significant improvement in hirsutism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kadınlar · Hirsutizm · Hiperinsülinizm

Abstract

OBJECTIVE: To evaluate the hormonal and clinical effects of metformin therapy in women with hirsutism. STUDY DESIGN: Prospective cohort study. Twelve weeks of therapy with oral metformin (850 mg two times per day) is applied to twenty eight women with hirsutism. Levels of insulin, testosteron, DHEA-S, gonadotropins (FSH, LH), biochemical measures and clinical symptoms including Ferriman-Gallway scores and regularity of menstrual cycle were assessed before and after treatment with metformin. RESULTS: Metformin therapy resulted with a significant decrease in insulin and total testosteron levels. There was a significant decline in mean body mass index, hirsutism scores and improvement in the menstrual cycle. There was not a significant difference in LH levels and LH/FSH ratios. CONCLUSION: Metformin treatment of women with hirsutism resulted in a decline of insulin and total testosteron levels leading to a significant improvement in hirsutism.

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Cite This Article

ALTINTAŞOĞLU, F. H., TANER, C. E., NAYKI, Ü. A., MIZRAK, T., KOÇUN, G., DİŞBUDAK, D. (2004). The effects of metformin therapy on hyperandrogenism and hyperinsulinemia in women with hirsutism. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 10 - Sayı: 2, 106–108. https://ajindex.com/articles/227211

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References (1)

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