Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2004 / Cilt: 10 - Sayı: 3

Avascular heterotopic ovarian transplantation into subcutaneous tissue in rats

Pages
194–196
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found out that serum hormone levels of control and transplant group did not show a significant difference in and between the groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To assess the recovery, maintenance, and quality of ovarian function by detecting hormonal status and hystopathologic examination of autotransplanted ovary in abdominal wall location in syngeneic winstar rats.
📊
Key Findings & Data:Hormone levels were measured on the basal day and at the end of the 12th week.
💡
Conclusion & Impact:It was found out that serum hormone levels of control and transplant group did not show a significant difference in and between the groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Yumurtalık · Sıçan · Wistar

Abstract

Objective: To assess the recovery, maintenance, and quality of ovarian function by detecting hormonal status and hystopathologic examination of autotransplanted ovary in abdominal wall location in syngeneic winstar rats. Study Design: This experimental study was conducted in the Unit of Experimental Research at the Ondokuz Mayıs University, School of Medicine. Autologous heterotopic transplantation of ovarian tissue was performed without vascular pedicle in rats. Hormone levels were measured on the basal day and at the end of the 12th week. Also, hystopathologic examination of the transplanted ovaries were performed at the end of the experiment. Results: All of the transplanted ovaries were successfully vascularised and there was no necrosis among ovarian species on hystopathological evaluation. It was found out that serum hormone levels of control and transplant group did not show a significant difference in and between the groups. Conclusion: A heterotopic autotransplant of ovary without vascular pedicle in syngeneic Wistar rats was 100% successful without any necrosis in our animals.

🔖

Cite This Article

ÇETİNKAYA, B. M., KÖKÇÜ, A., AYDIN, O., ALİYAZICIOĞLU, Y., MALATYALIOĞLU, E., ÖCAL, G., ALPER, T. (2004). Avascular heterotopic ovarian transplantation into subcutaneous tissue in rats. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 10 - Sayı: 3, 194–196. https://ajindex.com/articles/227174

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (2)

  1. Ries L, Percy C, Bunin G. In: Ries L, Smith M, Gurney J et al., editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995.
  2. National Cancer Institute, SEER Program. Bethesda, MD: NIH Pub. No. 1999; 99-4649:1-15. 2.Meirow D, Epstein M, Lewis H, Nugent D, Gosden RG. Administration of cyclophosphamide at different stages of follicular maturation in mice: effects on reproductive performance and fetal malformations. Hum. Reprod. 2001; 16:632-7. 3.Morris R.A case of heteroplastic ovarian grafting, followed by pregnancy, and the delivery of a living child. MedRec 1996; 69:697-8. 4.Lara HE, Hiney JK, Dissen GA, Rivier C, Ojeda SR. Functional recovery of the developing rat ovary after transplantation: contribution of the extrinsic innervation. Endocrinology 1991; 129:1849-60. 5.Dissen GA, Lara HE, Fahrenbach WH, Costa ME, Ojeda SR. Immature rat ovaries become revascularized rapidly after autotransplantation and show a gonadotrop independent increase in angiogenic factor gene expression. Endocrinology 1994; 134:1146-54. 6.Campbell BK, Baird DT, McNeylly AS. Ovarian secretion rates and peripheral concentrations of inhibin in normal and androstenedione immune ewes with an autotransplanted ovary. J. Endocrinol 1990; 127:285-96. 7.Jesionowska H. Effects of chronic exposure to estradiol on ovarian cyclicity in c57bl/65 mice: potentiation at low doses and only partial suppression at high doses. Biol Reprod 1990; 43:312-7. 8.Nelson JF, FelicioLS, Osterburg HH, Finch CE. Differential contributions of ovarian and extra-ovarian factors to age-related reductions in plasma estradiol and progesterone during estrous cycle. Endocrinology 1992; 130:805-10. 9.Tobias JH, Chambers TJ, Gallagher A. The effects of ovarian transplantation on bone loss in ovariectomized rats. J Endocrinol 1994; 142:187-92. 10.Gallagher AC, Chambers TJ, Tobias JH. Distinct effects of ovarian transplantation and exogenous 17 estradiol on cancellous bone of osteopenic ovariectomized rats. Eur J Endocrinol 1995; 133:483-8. ll.Aubard Y, Teissier MP, Baudet JH. Greffes et transplantations ovariennes chez the femme: le point. Rev Fr Gynecol Obstet 1993; 88:583-90. 12.von Eye Corleta H, Corleta O, Capp E, Edelweiss MI. Subcutaneous autologous ovarian transplantation in Wistar rats maintains hormone secretion. Fertil Steril 1998; 70:16-9. 13.Gosden RG. Restitution of fertility in sterilized mice by transferring primordial ovarian follicles. Hum Reprod 1990; 5:499-