Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2009 / Cilt: 15 - Sayı: 2

Preeklampsili Kadınlarda Artmış İnsülin Seviyeleri Gebelik Kilo Fazlalığından Bağımsızdır

Increased Insulin Levels Independent of Gestational Overweight in Women with Preeclampsia

Pages
75–80
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

RESULTS: The results show that there is no relation between high and normal BMI values and insulin resistance in patients with preeclampsia.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To evaluate whether increased insulin levels are independent of gestational overweight in women with preeclampsia.
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Key Findings & Data:STUDY DESIGN: The patients studied were selected at the Zeynep Kamil Woman and Children's Hos - pi tal during their 29th and 40th week of pregnancy.
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Conclusion & Impact:RESULTS: The results show that there is no relation between high and normal BMI values and insulin resistance in patients with preeclampsia.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To evaluate whether increased insulin levels are independent of gestational overweight in women with preeclampsia. STUDY DESIGN: The patients studied were selected at the Zeynep Kamil Woman and Children's Hos - pi tal during their 29th and 40th week of pregnancy. The patients were evaluated in the four groups according to the diagnosis of preeclampsia (PE) and body mass index (BMI), group 1 overweight patients with mild preeclampsia (n=20), group 2 overweight patients without preeclampsia (n=20), group 3 nonoverweight patients with mild preeclampsia (n=20), and group 4 non-overweight patients without preeclamp sia (n=20). The serum fasting glucose and immunorective insulin levels were determined, and Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The results show that there is no relation between high and normal BMI values and insulin resistance in patients with preeclampsia. Although, it was found that the HOMA-IR values of the patients with PE were higher than without PE. CONCLUSIONS: The results indicate that there was no relation between the increased insulin resistance and the weight gain. Increased insulin resistance should be developed as a result of the pathophysiology of the preeclampsia itself.

Özet

AMAÇ: Bu çalışmanın amacı fazla kilolu eklampsili hastalarda artmış insülin düzeylerinin kilo fazlalığı ile ilgisi olup olmadığını araştırmaktır. GEREÇ ve YÖNTEM: Bu amaçla Zeynep Kamil Kadın ve Ço - cuk Hastanesine başvuran 29-40 gebelik haftaları arasındaki gebeler çalışmaya dahil edilmiştir. Gebeler preeklampsi olup olmadığı ve fazla kilolu olup olmadıklarına gore 4 gruba ayrıldı; grup1 fazla kilolu ve hafif-orta eklampsili (n=20), grup 2 fazla kilolu normal (n=20), grup 3 normal kilolu hafif orta preeklampsili (n=20), grup 4 normal kilolu normal gebelerden oluşturuldu. Vakaların açlık glikoz ve immünoreaktif insülin seviyeleri ölçüldü, insülin direnci HOMA-IR formula ile hesaplandı. BULGULAR: Preeklampsili hastalarda insülin direnci fazla kilolu ve normal kilolu vakalar için benzer bulunduğu halde preeklampsili hastaların HOMA-IR değerleri normal gebelerden yüksek idi. SONUÇ: Eklampsili hastalarda kilo alımının insülin seviyelerinden bağımsız olduğu ve bu hastalarda insülin direnci eklampsiye yol açan ana fizyopatolojinin bir sonucunda gelişmiş olmalıdır

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Cite This Article

GÜNEY, B. S., TAŞKALE, M. G., PEKİN, O., DAYICIOĞLU, V., KÜÇÜKBAŞ, M. (2009). Preeklampsili Kadınlarda Artmış İnsülin Seviyeleri Gebelik Kilo Fazlalığından Bağımsızdır. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 15 - Sayı: 2, 75–80. https://ajindex.com/articles/227038

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