We present an atypical case of endometrial cancer formerly submitted to pelvic irradiation because of cervical carcinoma and we discuss the eventual association of pelvic radiation with a subsequent endometrial carcinoma.
📌 3 Key Takeaways
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Objective & Hypothesis:The subject of whether cancer treatment causes cancer is less widely recognized but obviously not insignificant.
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Key Findings & Data:Although previous studies have attempted to address the concept of “postradiation carcinoma” there is no direct evidence that these tumors are caused by radiation or simply present incident malignancies in an at-risk population.
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Conclusion & Impact:We present an atypical case of endometrial cancer formerly submitted to pelvic irradiation because of cervical carcinoma and we discuss the eventual association of pelvic radiation with a subsequent endometrial carcinoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
The subject of whether cancer treatment causes cancer is less widely recognized but obviously not insignificant. Although previous studies have attempted to address the concept of “postradiation carcinoma” there is no direct evidence that these tumors are caused by radiation or simply present incident malignancies in an at-risk population. The risk of second primary cancer in women with cervical cancer in previously irradiated fields remains still unclear. We present an atypical case of endometrial cancer formerly submitted to pelvic irradiation because of cervical carcinoma and we discuss the eventual association of pelvic radiation with a subsequent endometrial carcinoma.
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Cite This Article
THOMAKOS, N., RODOLAKIS, A., AKRIVOS, N., PALAIOLOGOS, P., HAIDOPOULOS, D., VLAHOS, G., ANTSAKLIS, A. (2010). Does cancer therapy causes cancer? A case report and mini review of the literature. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 16 - Sayı: 2, 130–131. https://ajindex.com/articles/227015
Kleinerman RA, Curtis RE, Boice JD Jr, et al. Second cancers following radiotherapy for cervical cancer. J Natl Cancer Inst 1982; 69:1027-33
Pride GL, Buchler DA. Carcinoma of the vagina 10 or more years following pelvic irradiation therapy. Am J Obstet Gynecol 1977;127:513-7
Evans HS, Newnham A, Hodgson SV, et al. Second primary cancers after cervical intraepithelial neoplasia III and invasive cervical cancer in Southeast England. Gynecol Oncol 2003;90:131-6
Meredith RF, Eisert DR, Kaka Z, et al. An excess of uterine sarcomas after pelvic irradiation. Cancer 1986; 58:2003-7
Thompson DE, Mabuchi K, Ron E, et al. Cancer incidence in atomic bomb survivors. Part II: solid tumors, 1958- 1987. Radiat Res 1994;137(2 Suppl):S17-67
Ron E, Ikeda T, Preston DL, et al. Male breast cancer incidence among atomic bomb survivors. J Natl Cancer Inst 2005;97:603-5
Weiss SW, Goldblum JR. Enzinger and Weiss_s Soft Tissue Tumors, 4th edn. Philadelphia, PA: Mosby, 2001:3- 4
Norris HJ, Taylor HB. Postirradiation sarcomas of the uterus. Obstet Gynecol 1965;26:689-94
Ronnett BM, Zaino RJ, Ellenson LH, et al. Endometrial carcinoma. In: Kurman RJ, ed. Blaustein_s Pathology of the Female Genital Tract, 5th edn. New York: Springer Verlag, 2002:501-9
Seidman JD, Kumar D, Cosin JA et al. Carcinomas of the female genital tract occurring after pelvic irradiation:A report of 15 cases. Int J Gynecol Pathol 2006;25:293-7
Parkash V, Carcangiu ML. Uterine papillary serous carcinomas after radiation therapy for carcinoma of the cervix. Cancer 1992;69:496-501
Pothuri B, Ramondetta L, Martino M, et al. Development of endometrial cancer after radiation treatment for cervical carcinoma. Obstet Gynecol 2003;101:941-5.