Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2015 / Cilt: 21 - Sayı: 2

Normal Gebeliklerde Kordon Kanı Safra Asit Seviyesinin İntrauterin Mekonyum Pasajı Üzerine Etkisi

The Effect of Cord Blood Bile Acid Levels on the Meconium Passage in Utero in Normal Pregnancies

Pages
62–65
DOI
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We didn't find a statistically significant difference in cord bloodbile acid levels between the two groups.CONCLUSION: Cord blood bile acid levels appeared to have no significant effect of meconium passagein normal pregnancies

📌 3 Key Takeaways

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Objective & Hypothesis:To investigate the effect of bile acids on meconium passage in utero in normal pregnancies.
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Key Findings & Data:STUDY DESIGN: This prospective case control study was performed at Zekai Tahir Burak Women'sHealth and Teaching Hospital between September 1, 2010 and January 1, 2011.
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Conclusion & Impact:We didn't find a statistically significant difference in cord bloodbile acid levels between the two groups.CONCLUSION: Cord blood bile acid levels appeared to have no significant effect of meconium passagein normal pregnancies
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

To investigate the effect of bile acids on meconium passage in utero in normal pregnancies. STUDY DESIGN: This prospective case control study was performed at Zekai Tahir Burak Women'sHealth and Teaching Hospital between September 1, 2010 and January 1, 2011. Inclusion criteria were:singleton viable pregnancy, gestational age >=37 weeks. Exclusion criteria were: presence of any maternal disease, obstetric cholestasis, hepatic infections and multiple pregnancies. Sixty one pregnantwomen were recruited for the study: 31 women with meconium stained amnion liquid and 30 womenwith normal amnion liquid. Demographic data and clinical data were collected. Each patient's cord bloodgases, cord blood bile acids levels, maternal serum liver function tests and bilirubin levels were investigated.RESULTS: There were no significant differences in maternal age, gestational age, parity and body massindex. We found no differences in the serum bilirubin levels and liver function tests. And there were alsono differences in the cord blood gas values between the two groups. The mode of delivery was significantly different between the two groups. We didn't find a statistically significant difference in cord bloodbile acid levels between the two groups.CONCLUSION: Cord blood bile acid levels appeared to have no significant effect of meconium passagein normal pregnancies

Özet

Normal gebeliklerde umblikal kord safra asitlerinin intrauterin mekonyum pasajı üzerine olan etkisini araştırmak.GEREÇ VE YÖNTEM: Bu prospektif vaka kontrol çalışması, 1Eylül 2010 ile 1 Ocak 2011 tarihleri arasında Zekai Tahir BurakKadın Sağlığı Eğitim ve Araştırma Hastanesi'nde doğum yapan tekil canlı, 37 hafta üstü gebeler üzerinde yapıldı. Gebeliği37 haftadan küçük olan, herhangi bir sistemik hastalığı olan,obstetrik kolestazı, hepatik enfeksiyonu veya çoğul gebeliğiolan kadınlar çalışma dışında tutuldu. Doğumda amnion mayisi mekonyumlu olan 31 gebe vakaları, amnion mayisi normalolan 30 gebe ise kontrol grubunu oluşturdu. Her iki grupta kordon kanı gazı değerleri, kordon kanı safra asit seviyeleri, maternal serum karaciğer fonksiyon testleri ve bilirubin seviyelerikarşılaştırıldı.BULGULAR: Gruplar arasında maternal yaş, gestasyonel yaş,parite ve vücut kitle indeksi açısından fark yoktu. Vakalar vekontroller arasında serum bilirubin seviyeleri ve karaciğer fonksiyon testleri açısından herhangi bir fark tespit edilmedi. Umb likal kordon kanı gaz değerleri açısından da iki grup arasındafark yoktu. Beklendiği gibi mekonyumlu amniyon mayisi olangrupta normal amniyonu olan gruba göre istatistiksel olarakanlamlı olacak şekilde sezaryan oranı fazlaydı (%45,2 vs%16,7; p=0,01). Kordon kanı safra asit seviyesi ve pH'sı için deher iki grup arasında anlamlı fark saptanmadı.SONUÇ: Normal gebeliklerde kordon kanı safra asit seviyelerinin mekonyum pasajı üzerine herhangi bir etkisi olmadığı görülmektedir

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Cite This Article

YILMAZ, S. S., HIZLI, D., ÜSTÜN, Y. E., YILMAZ, E., EYİ, E. G. Y., MOLLAMAHMUTOĞLU, L. (2015). Normal Gebeliklerde Kordon Kanı Safra Asit Seviyesinin İntrauterin Mekonyum Pasajı Üzerine Etkisi. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 21 - Sayı: 2, 62–65. https://ajindex.com/articles/226991

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