Journals / Gülhane Tıp Dergisi / 2004 / Cilt: 46 - Sayı: 3

Leukemic infiltration of the prostate in a man with polycystic kidney disease: A possible pathophysiological mechanism

Polikistik böbrekli bir hastada prostatın lösemik infiltrasyonu: Olası bir patofizyolojik mekanizma

Pages
258–259
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To our knowledge, this is the first report of a case with coexistence of autosomal dominant polycystic kidney disease (ADPKD), CLL and its prostatic infiltration diagnosed by transrectal ultrasonography (TRUS) guided prostate biopsy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Leukemic infiltration of the prostate has rarely been reported.
📊
Key Findings & Data:The majority of the published cases with prostatic involvement were chronic lymphocytic leukemia (CLL).
💡
Conclusion & Impact:To our knowledge, this is the first report of a case with coexistence of autosomal dominant polycystic kidney disease (ADPKD), CLL and its prostatic infiltration diagnosed by transrectal ultrasonography (TRUS) guided prostate biopsy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Polikistik böbrek hastalıkları · Prostat · Lösemi

Abstract

Leukemic infiltration of the prostate has rarely been reported. The majority of the published cases with prostatic involvement were chronic lymphocytic leukemia (CLL). An autopsy series of leukemia patients documented an actual prevalence of prostatic involvement higher than clinical series. To our knowledge, this is the first report of a case with coexistence of autosomal dominant polycystic kidney disease (ADPKD), CLL and its prostatic infiltration diagnosed by transrectal ultrasonography (TRUS) guided prostate biopsy.

Özet

Prostatın lösemik infiltrasyonu nadir olarak bildirilmiştir. Rapor edilen vakaların büyük çoğunluğu, kronik lenfositik löseminin (KLL) prostatik tutulumu şeklindedir. Lösemi hastaları üzerinde yapılan otopsi serilerinde, prostat tutulumunun klinik serilerden daha yüksek prevalansa sahip olduğu dokümante edilmiştir. Bizim bilgilerimize göre bu olgu, otozomal dominant polikistik böbrek hastalığının (ODPBH), KLL ve prostatik infiltrasyon ile birliktelik gösterdiği ve tanısının transrektal ultrasonografi eşliğinde biyopsi ile konulduğu ilk vaka raporudur.

🔖

Cite This Article

KİBAR, Y., BEDİR, S., KİLCİLER, M., DEVECİ, M. S., ÖZGÖK, Y. (2004). Leukemic infiltration of the prostate in a man with polycystic kidney disease: A possible pathophysiological mechanism. Gülhane Tıp Dergisi, Cilt: 46 - Sayı: 3, 258–259. https://ajindex.com/articles/226367

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Terris, M.K., Hausdorff. J., and Freiha. F.S.: Hematolymphoid malignancies diagnosed at the time of radical prostatectomy. J Urol 1997; 158:1457-1459
  2. Rai, K.R., Sawitsky, A., Cronkite, E.P., et al.: Clinical staging of chorinic lymphocytic leukemia. Blood 1975, 46:219
  3. Nouri, M., Ibnattya, A., Elkhader, K., et al.: Prostatic chronic lymphocytic leukemia. Report of 2 cases. Ann Urol 1999, 33(4):268-270
  4. Perez Arbej, J.A., Lopez, Carreira, M., Arnaiz, Esteban, F., et al.: Diagnosis of leukemic infiltration of the prostate prompted by PSA elevation. Actas Urol Esp 1996, 20(10):892-894
  5. Belhiba, H., Casse, C., Katmeh, S., Bourdon, J.: Prostatic involvement in leukemia. Report of a case. Prog Urol 1992, 2(4):650-652
  6. Vicente, E.T.: New insights into polycystic kidney disease and its treatment. Cur Opin Nephrol Hypertension 1998; 7:159-169
  7. Aguiari,G., Savelli, S., Garbo, M., et al.: Novel splicing and missense mutations in autosomal dominant polycystic kidney disease 1 (PKD1) gene: expression of mutated genes. Hum Mutat 2000 16(5):444-5
  8. Aguiari, G, Piva, R., Manzati, E., et al.: K562 erythroid and HL60 macrophge differentiation downregulates polycystin, a large membrane-associted protein. Exp Cell Res 1998; 10;244(1):259- 267.