Impact of renal dysfunction on coronary blood flow

Objective & Hypothesis:Objectives: Slow coronary flow SCF has long been identified and endothelial dysfunction and atherosclerosis of epicardial coronary arteries and microvasculature were reported to be associated with SCF.

📊

Key Findings & Data:Design and Methods: Ninety-two patients with SCF and 562 control cases with normal coronary flow were studied after quantifying coronary blood flow according to TFC.

💡

Conclusion & Impact:Mean TFC was correlated with age r=0.113, p=0.004 , gender r=0.152, p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Ateroskleroz · endotel disfonksiyonu · glomerüler filtrasyon hızı

Abstract

Objectives: Slow coronary flow SCF has long been identified and endothelial dysfunction and atherosclerosis of epicardial coronary arteries and microvasculature were reported to be associated with SCF. Impact of renal functions on atherosclerosis and endothelial dysfunction has been reported. Consequently, we aimed to investigate the association between coronary blood flow by means of TIMI frame count TFC and renal functions and other laboratory parameters in patients with SCF compared to control cases. Design and Methods: Ninety-two patients with SCF and 562 control cases with normal coronary flow were studied after quantifying coronary blood flow according to TFC. Estimated glomerular filtration rate eGFR was evaluated with Cockcroft-Gault equation. The association between TFC and eGFR and other clinical and laboratory parameters were evaluated. Results: There were statistically significant differences between SCF and control groups in respect to gender, systolic blood pressure, heart rate, serum uric acid and creatinine levels, hematocrit and eGFR. Mean TFC was correlated with age r=0.113, p=0.004 , gender r=0.152, p

Özet

Giriş: Yavaş koroner akım YKA uzun zamandır bilinmektedir ve endotel disfonksiyonu ve epikardiyal koroner arterler ve mikrovasküler yatağın aterosklerozu ile ilişkisi bildirilmiştir. Renal disfonksiyonun, ateroskleroz ve endotel disfonksiyonu üzerine etkili olduğu bildirilmiştir. Bu çalışma ile YKA ve kontrol gruplarında TIMI kare sayısı TKS ile ölçülen koroner kan akımı ile renal fonksiyonların ve diğer laboratuar parametrelerinin ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Design and Methods: Çalışmaya koroner kan akım hızları TKS ile değerlendirilmiş olan 92 YKA ve 562 kontrol olgusu dahil edildi. Tahmini glomerüler filtrasyon hızı tGFH Cockcroft-Gault eşitliği ile hesaplandı. TKS ve tGFH ve diğer klinik ve laboratuar parametreler arasındaki ilişki incelendi. Bulgular: Kontrol ve YKA gruplarının kıyaslanmasında iki grup arasında cinsiyet, sistolik kan basıncı, kalp hızı, serum ürik asit ve kreatinin düzeyleri, hematokrit ve tGFH yönünden istatistiksel anlamlı farklılıklar mevcut idi. Ortalama TKS yaş r=0.113, p=0.004 , cinsiyet r=0.152, p

Keywords

Ateroskleroz endotel disfonksiyonu glomerüler filtrasyon hızı koroner arter hastalığı koroner mikrovasküler yatak yavaş koroner akım Atherosclerosis coronary artery disease coronary microvasculature endothelial dysfunction glomerular filtration rate slow coronary flow

🔖

Cite This Article

YILDIZ, A., SEZEN, Y., GUR, M., YILMAZ, R., DEMIRBAG, R., EREL, O. (2008). Impact of renal dysfunction on coronary blood flow. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 5 - Sayı: 2, 11–18. https://ajindex.com/articles/22631

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (12)

Lindner A, Charra B, Scribner BH. Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;290:697−701. Sherrard DJ, Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement Association Cardiovascular Disease, High Blood Pressure Research, Epidemiology and Prevention. Circulation 2003;108: 2154–69. American on Councils Kidney in Clinical Cardiology and 3. Cin VG, Pekdemir H, Camsar A, et al. Diffuse intimal thickening of coronary arteries in slow coronary flow. Jpn Heart J 2003;44:907–19.
Mosseri M, Yarom R, Gotsman MS, Hasin Y. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation 1986;74:964–72.
Sezgin AT, Sigirci A, Barutcu I, et al. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 2003;14:155–61.
Riza Erbay A, Turhan H, Yasar AS, et al. Elevated level of plasma homocysteine in patients with slow coronary flow. Int J Cardiol 2005;102:419–23.
Yildiz A, Yilmaz R, Demirbag R, Gur M, Bas MM, Erel O. Association of serum uric acid level and coronary blood flow. Coron Artery Dis 2007;18:607–13.
Selcuk MT, Selcuk H, Temizhan A, et al. Asymmetric concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary 2007;18:545–51. plasma flow. Coron Artery Dis 9. Li JJ, Qin XW, Li ZC, et al. Increased plasma C-reactive concentrations in patients with slow coronary flow. Clin Chim Acta 2007;385:43–7.
Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996;93:879–88.
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31–41.
Zoungas S, Ristevski S, Lightfoot P, et al. Carotid artery intima-medial thickness is increased in chronic renal failure. Clin Exp Pharmacol Physiol 2000;27:639–41.
Leskinen Y, Lehtimäki T, Loimaala A, et al. Carotid atherosclerosis in chronic renal failure-the central role of increased plaque burden. Atherosclerosis 2003;171:295–302.
Rashid ST, Salman M, Agarwal S, Hamilton G. Occult renal impairment is common in patients with peripheral vascular disease and normal serum creatinine. Eur J Vasc Endovasc Surg 2006;32:294–9.
Kramer H, Toto R, Peshock R, Cooper R, Victor R. Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study. J Am So