Journals / Gülhane Tıp Dergisi / 2002 / Cilt: 44 - Sayı: 4

A case of toxic hepatitis due to terbinafine

Terbinafine bağlı bir toksisk hepatit olgusu

Pages
447–449
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our case was defined as toxic hepatitis due to oral tebinafine because there was no clinical and laboratory findings but oral terbinafine intake and clinical and laboratory findings were normalized after cessation of terbinafine.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Terbinafine is an antifungal drug having many side-effects.
📊
Key Findings & Data:One of these side-effects is hepatobiliary dysfunction including acute hepatitis.
💡
Conclusion & Impact:Our case was defined as toxic hepatitis due to oral tebinafine because there was no clinical and laboratory findings but oral terbinafine intake and clinical and laboratory findings were normalized after cessation of terbinafine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit · İlaç toksisitesi · İlaç tedavisi

Abstract

Terbinafine is an antifungal drug having many side-effects. One of these side-effects is hepatobiliary dysfunction including acute hepatitis. In this study, a case of toxic hepatitis due to terbinafine is presented. Our case was defined as toxic hepatitis due to oral tebinafine because there was no clinical and laboratory findings but oral terbinafine intake and clinical and laboratory findings were normalized after cessation of terbinafine.

Özet

Terbinafin bir çok yan etkisi olan antifungal bir ilaçtır. Bu yan etkilerden biri de akut hepatit de dahil hepatobiliyer disfonksiyonlardır. Bu çalışmada oral terbinafıine bağlı bir toksik hepatit tablosu sunulmaktadır. Olgumuz, oral terbinafin kullanımı dışında karaciğer hasarını açıklayacak klinik ve laboratuar bulgu saptanamaması ve terbinafinin kesilmesi ile kısa sürede klinik tablonun ve laboratuar bulgularının düzelmesi nedeni ile terbinafine bağlı toksik hepatit tablosu olarak değerlendirilmiştir.

🔖

Cite This Article

TURHAN, V., AVCI, İ. Y., DOĞRU, T., EYİGÜN, C. P., PAHSA, A. (2002). A case of toxic hepatitis due to terbinafine. Gülhane Tıp Dergisi, Cilt: 44 - Sayı: 4, 447–449. https://ajindex.com/articles/226289

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Wilmer, A., Wollina, U.: Systemic terbinafine treatment of dermatophytoses. Mycoses 1998; 41 Suppl: 254-7
  2. Gupta, A.K., del Rosso, J.Q., Lynde, C.W., Brown, GH., Shear, NH.: Hepatitis associated with terbinafine therapy: three case, a review of the lierature. din Exp Dermatol 1998;23(2):64-7
  3. Conjeevaram, G., Vongthavaravat, V., Summer, R., Koff, RS.: Terbinafine-induced hepatitis and pancytopenia. Dig Dis Sci 2001; 46 (8): 1714-6
  4. Shapiro, M., Li, LJ., Miller, J.: Terbinafine induced neutropenia. Br J Dermatol 1999; 140(6):1196-7
  5. Grunwald, MH.: Trombocytopenia associated with oral terbinafine. Int J Dermatol 1998; 37(8): 634
  6. Barete, S., Bissuel, F., Longuet, P., Pocidolo, MA., Leport, C, Vide, JL.: Agranulocytosis du¬ ring a treatmet with terbinafine. Rev Med Interne 1997; 18(3): 258-9
  7. Lee, MS., Lau, AK., Crosland, G., Caterson, R.: Renal impairment associated with oral terbinafine. BrJ Dermatol 1996; 134(2): 374-5
  8. Duxbury, AJ., Oliver, RJ., Pemberton, MA/.: Persistent impairment of taste associated with terbinafine. Br Dent J 2000; 188(6): 295-6
  9. Gupta, AK., Gönder, JR., Shear, NH., Dilworth, GR.: The development of green vision in asso¬ ciation with terbinafine. Arch Dermatol 1996; 132(7): 845-6
  10. Wilson, NJ., Evans, S.: Severe pustular psoriasis provoked by oral terbinafine. Br J Dermatol 1998; 139(1): 168
  11. Torrens, JK., McWhinney PH.:Parotid swelling and terbinafine. BMJ 1998; 316(7129): 440-1
  12. Gupta, AK., Kopstein, JB., Shear, NH.: Hypersensitivity reaction to terbinafine. J Am Acad Dermatol 1997; 36 (6 Pt 1): 1018-9
  13. Murphy, M., Barnes, L.: Terbinafine-induced lupus erythematosus. Br J Dermatol. 1998; 138(4): 708-9
  14. Lowe, G., Green, C, Jenniggs, P.: Hepatitis associated with terbinafine treatment. BMJ 1993; 306(6872): 248
  15. Vivas, S., Rodriguez, M., Palacio, MA., Cadenas. F, Lomo, J., Rodrigo, L: Acute hepatitis asso¬ ciated with terbinafine. Gastroenterol Hepatoi 1997; 20(9): 456-8
  16. Tejeda Garcia, M., Llvona Hevia, A.M., Martin Arias, L, Garcia-Pando, A.C.: Terbinafine and cholestatic hepatitis. Med Clin 1997; 109(9): 356
  17. Boldewijn, OY, Ottervanger, JR., Mostart, CM., Janssens, AR., Caleme, J., Jonke, GJ.: Hepatitis attributed to the use of terbinafine. Ned Tijdscr Geneeskd 1996; 140(12): 669-72
  18. Vantaux, P., Grasset, D., Nougue, J., Lagier, E., Seigneuric, C: Acute hepatitis related to inges- tion of terbinafine. Gastroenterol Clin Biol 1996; 20(4): 402-3
  19. Van't Wout, J.W., He