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Journals / Gülhane Tıp Dergisi / 2004 / Cilt: 46 - Sayı: 4

A case of congestive heart failure secondary to congenital heart disease with left to right shunt who developed pancytopenia due to use of enalaprile

Sol-sağ şantlı doğumsal kalp hastalığına sekonder konjestif kalp yetersizliği nedeniyle enalapril kullanılan bir olguda gelişen pansitopeni

A. Avni ATAY
Vedat OKUTAN
A. Emin KÜREKÇİ
Mustafa Koray LENK
Nadir KORKMAZER
Okan ÖZCAN
Pages
340–342
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here in we report on 8-month-old boy large atrial septal defect, pulmonary hypertension and congestive heart failure who was on digoxin and enalaprile therapy for two months and developed pancytopenia and successful treatment of agranulo cytosis with recombinant granulocyte-colony-stimulating factor (G-CSF).

📌 3 Key Takeaways

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Objective & Hypothesis:Angiotensin I Converting Enzyme (ACE) inhibitors are widely used in congenital heart diseases with left to right shunt, mitral and aortic insufficencies and congestive heart failure.
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Key Findings & Data:Bone marrow supression according to the usage of ACE inhibitors is uncommon and pancytopenia have not been reported with enalaprile.
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Conclusion & Impact:Here in we report on 8-month-old boy large atrial septal defect, pulmonary hypertension and congestive heart failure who was on digoxin and enalaprile therapy for two months and developed pancytopenia and successful treatment of agranulo cytosis with recombinant granulocyte-colony-stimulating factor (G-CSF).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Enalapril · Kalp hastalıkları · Kalp yetmezliği

Abstract

Angiotensin I Converting Enzyme (ACE) inhibitors are widely used in congenital heart diseases with left to right shunt, mitral and aortic insufficencies and congestive heart failure. Bone marrow supression according to the usage of ACE inhibitors is uncommon and pancytopenia have not been reported with enalaprile. Here in we report on 8-month-old boy large atrial septal defect, pulmonary hypertension and congestive heart failure who was on digoxin and enalaprile therapy for two months and developed pancytopenia and successful treatment of agranulo cytosis with recombinant granulocyte-colony-stimulating factor (G-CSF).

Özet

"Angiotensin I Converting Enzyme" (ACE) inhibitörleri, soldan sağa şantlı doğumsal kalp hastalıklarında, mitral ve aort kapak yetersizliklerinde ve konjestif kalp yetersizliğinde giderek artan sıklıkla kullanılmaktadır. ACE inhibitörlerinin kullanımına bağlı kemik iliği supresyonu nadir olup, enalaprile bağlı pansitopeni hiç bildirilmemiştir. Bu sunumda kliniğimizde geniş atriyal septal defekt, pulmoner hipertansiyon ve konjestif kalp yetersizliği nedeni ile dış merkez tarafından dijitalize edilip 2 aydır da enalapril kullanmakta olan 8 aylık bir erkek bebeğin, enalapril kullanımına bağlı pansitopenisi ve agranülositozun rekombinan granülosit stimüle edici faktör (G-CSF) ile başarılı tedavisi sunulmaktadır.

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Cite This Article

ATAY, A. A., OKUTAN, V., KÜREKÇİ, A. E., LENK, M. K., KORKMAZER, N., ÖZCAN, O. (2004). A case of congestive heart failure secondary to congenital heart disease with left to right shunt who developed pancytopenia due to use of enalaprile. Gülhane Tıp Dergisi, Cilt: 46 - Sayı: 4, 340–342. https://ajindex.com/articles/226260

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