Journals / Gülhane Tıp Dergisi / 2008 / Cilt: 50 - Sayı: 1

Acute appendicitis: ligation of appendix (an ex perimental model in rabbits)

Akut apandisit: apandiksin bağlanması (tavşanlarda deneysel model)

Pages
27–29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In our particular experimental experience ligation of appendix was found as a successful method in constituting a model of acute appendicitis.

📌 3 Key Takeaways

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Objective & Hypothesis:Acute appendicitis: ligation of appendix (An experimen- tal model in rabbits) The evolving phases of acute appendicitis were studied in rabbits using an experimental model.
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Key Findings & Data:Twenty one male rab- bits from New Zeland lineage (oryctogalus cuniculus) weig- hing approximately 3.000 grams each were included.
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Conclusion & Impact:In our particular experimental experience ligation of appendix was found as a successful method in constituting a model of acute appendicitis.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Tavşanlar · Akut hastalık · Apandisit

Abstract

Acute appendicitis: ligation of appendix (An experimen- tal model in rabbits) The evolving phases of acute appendicitis were studied in rabbits using an experimental model. Twenty one male rab- bits from New Zeland lineage (oryctogalus cuniculus) weig- hing approximately 3.000 grams each were included. The animals were divided into three groups. Appendix was liga- ted with No=0 silk ties from 7-8 cm distal. Appendectomy was performed 12, 24 and 36 hours after the ligation of appendix in Group I, Group II and Group III, respectively. All the appendectomy materials were macroscopically and microscopically examined. Experimental obstruction of the appendix resulted in inflammatory changes in the wall of the appendix in all of the cases, histopathologically similar to seen in humans. There was a close relationship between the histopathological findings and time period passing after the occlusion of appendix. In our particular experimental experience ligation of appendix was found as a successful method in constituting a model of acute appendicitis.

Özet

Tavşanlarda deneysel model çalışılarak akut apandisitin evreleri değerlendirilmiştir. Yeni Zelanda ırkından, ağırlıkları yaklaşık 3000 gr olan yirmi bir adet erkek tavşan (oryctogalus cuniculus) çalışmaya dahil edildi. Hayvanlar üç gruba ayrıldı. Deneysel modelde apandiks yaklaşık 7-8 cm distalinden 0 numara ipekle ligate edildi. Grup I'dekilere ligasyondan 12 saat, Grup II'dekilere 24 saat, Grup III'dekilere 36 saat sonra apandektomi yapıldı. Bütün apandektomi materyalleri makroskopik ve mikroskopik olarak değerlendirildi. Olguların hepsinde apandiksin deneysel obstrüksiyonu histopatolojik olarak insanlardakine benzer şekilde apandiks duvarında inflamatuvar değişiklikler ile sonuçlandı. Apandiks obstrüksiyonundan sonra geçen zaman ile histopatolojik bulgular arasında yakın bir ilişki vardı. Deneysel çalışmamızın verileri ışığında apandiks ligasyonu akut apandisit modeli oluşturmada başarılı bir yöntem olarak bulunmuştur.

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Cite This Article

MENTEŞ, Ö., İDE, T., AKDAĞ, E., BALKAN, M., ÖNGÖRÜ, Ö., KOZAK, O., TUFAN, T. (2008). Acute appendicitis: ligation of appendix (an ex perimental model in rabbits). Gülhane Tıp Dergisi, Cilt: 50 - Sayı: 1, 27–29. https://ajindex.com/articles/226183

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References (4)

  1. Shelton T, McKilay R, Scwartz RW. Acute appendicitis: currrent diagnosis and treatment. Curr Surg 2003; 60: 502-505
  2. Dasso JF, Obiakor H, Bach H, et al. A morphological and immunological study of the human and rabbit appendix for comparison with the avian bursa. Dev Comp Immunol 2000; 24: 797-814
  3. Shanahan F, O'Sullivan GC. Appendectomy, mucosal immunity, and colitis. Gastroenterology 1997; 112: 1766- 1777
  4. Rothrock SG, Pagane J. Acute appendicitis in children: emergency department diagnosis and management. Ann Emerg Med 2000; 36: 39-51.