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Journals / Gülhane Tıp Dergisi / 2003 / Cilt: 45 - Sayı: 2

Cytokines in early experimental stroke

Erken dönem deneysel strokda sitokinler

MEHMET FATİH ÖZDAĞ
Semai BEK
Ümit Hıdır ULAŞ
Erdal EROĞLU
Zeki GÖKÇİL
Şeref DEMİRKAYA
Ali ŞENGÜL
Okay VURAL
Pages
114–116
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Stroke caused significant increases both on the levels of IL-6 and TNF-alpha in the stroke group (P=000).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Stroke is one of the leading causes of death and disability in major industrial countries.
📊
Key Findings & Data:In this study we investigated two of the cytokines: interleukin-6 (IL-6) and tumor necrosis factor - alpha (TNF-alpha) in an experimentally induced stroke (n=12) mice group and sham (n=9) mice group.
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Conclusion & Impact:Stroke caused significant increases both on the levels of IL-6 and TNF-alpha in the stroke group (P=000).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tümör nekroz faktör · Serebrovasküler olay · Sitokinler

Abstract

Stroke is one of the leading causes of death and disability in major industrial countries. The inflammatory response plays an important role in the potentiation of central nervous system (CNS) iscemie injury. Inflammatory response is mediated by cytokines. In this study we investigated two of the cytokines: interleukin-6 (IL-6) and tumor necrosis factor - alpha (TNF-alpha) in an experimentally induced stroke (n=12) mice group and sham (n=9) mice group. Stroke caused significant increases both on the levels of IL-6 and TNF-alpha in the stroke group (P=000).

Özet

Strok endüstriyel ülkelerde ölüm ve sakatlığa yol açan hastalıkların önde gelenlerinden birisidir. Santral sinir sistemindeki iskemik hasarın artmasında enflamatuvar cevap önemli yer tutar. Sitokinler enflamatuvar cevabı yönlendiren mediatörlerdir. Bu çalışmada deneysel strok oluşturulan farelerle (n=12) sham operasyonu uygulanan farelerin (n=9) iki majör sitokin düzeyleri, serum interlökin-6(IL-6) ve tümör nekrozis faktör - alfa (TNF-alfa) saptandı. Stroklu farelerin serum IL-6 ve TNF-alfa düzeyleri sham grubuna göre anlamlı düzeyde artmış bulundu(P=000)

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Cite This Article

ÖZDAĞ, M. F., BEK, S., ULAŞ, Ü. H., EROĞLU, E., GÖKÇİL, Z., DEMİRKAYA, Ş., ŞENGÜL, A., VURAL, O. (2003). Cytokines in early experimental stroke. Gülhane Tıp Dergisi, Cilt: 45 - Sayı: 2, 114–116. https://ajindex.com/articles/225729

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