AI Summary & Key Takeaways
AI InsightWe conclude that HBO2 therapy decreased the degradation of collagen by corrected hypoxia around chronic wound.
📌 3 Key Takeaways
Abstract
15 female and 20 male patients were included in the study in which we aimed to evaluate the serum and tissue prolidase levels after the hyperbaric oxygen (HBO2> therapy. All the cases had chronic refractory wound. HBO2 therapy was applied twice a day in 90 minute periods at 2 ATA. The treatment was discontinued after 30 periods. We collected venous blood samples and made skin biopsies before and after treatment. The prolidase enzyme was evaluated in serum and tissue samples before and after treatment. The prolidase enzyme activity in serum and tissue samples had a significant decrease after therapy (p<0.001). We conclude that HBO2 therapy decreased the degradation of collagen by corrected hypoxia around chronic wound.
Özet
Kronik yarası olan 15 kadın 20 erkek hastada, hiperbarik oksijen tedavisi (HBO2 sonrasında serum ve doku prolidaz enzim seviyeleri değerlendirildi. HBO2 günde 2 kez 90 dakikalık seanslar halinde uygulandı ve tedavi 30. seansta sonlandırıldı. Tedaviden önce ve sonra hastalardan venöz kan örnekleri ve doku biyopsileri alındı. Serum ve doku örneklerinde, prolidaz enzimler değerleri ölçüldü. Serum ve doku prolidaz değerleri, tedavi sonrasında, tedavi öncesine göre azalma istatistiksel olarak önemliydi (p<0.001). HBO2 tedavisinin kronik yara çevresindeki hipoksiyi düzelterek, kollajen yıkımını azaltığı düşünüldü.