Journals / Gülhane Tıp Dergisi / 2005 / Cilt: 47 - Sayı: 1

Treatment modalities in patients with condyloma acuminata of anogenital region

Anogenital bölge kondilomata aküminata olgularında tedavi yaklaşımları

Pages
29–33
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Surgical approach is the effective therapy for wide lesions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: Condyloma Acuminata is a venereal disease usually transmitted with sexual contact which is characterized with clinical and subclinical anogenital lesions caused by Human Papilloma Virus (HPV).
📊
Key Findings & Data:Many treatment methods have been described which can be separated into topical, immunotherapeutic, and surgical techniques.
💡
Conclusion & Impact:Surgical approach is the effective therapy for wide lesions.
🔬Design:Research Article
📍Scope:2003 Verileri
⚙️Variables:Tekrarlama · Geriyedönük çalışma · Kondilomata akuminata

Abstract

Background: Condyloma Acuminata is a venereal disease usually transmitted with sexual contact which is characterized with clinical and subclinical anogenital lesions caused by Human Papilloma Virus (HPV). Many treatment methods have been described which can be separated into topical, immunotherapeutic, and surgical techniques. Patients and Methods: Fifty patients with diagnosis of condylomata acuminata of the anogenital region, who were admitted to Surgical and Dermatological Clinics of Gulhane Military Medical Academy between 1990-2003, were retrospectively evaluated regarding to treatment modalities. Patients were treated with medical and surgical modalities regarding to locations and size of the lesions, some patients in medical group were additionally treated with cauterization. Results: There were 45 males and 5 females and mean patient age was 29.1 $\pm$ 8.8 in medical group and 30.0 $\pm$ 9.4 in surgical group. Mean follow up period was 20.0 $\pm$ 10.7 mounts in medical patients and 24.0 $\pm$ 15.0 mounts in surgical patients. Recurrence rate during follow up period was 22% (six patients) in medical groups whereas there was no recurrences in surgical patients. Conclusion: The best choice of treatment for a given patient depends on the extent and location of disease and the preferences of the clinician and the patient. Treatment modalities with topical agents can clear the small lesions in most of the patients with reasonable recurrence rates. Surgical approach is the effective therapy for wide lesions.

Özet

Giriş: Kondilomata akuminata, human papilloma virüslerin (HPV) neden olduğu anogenital bölgenin klinik ve subklinik lezyonları olup sıklıkla, seksüel yolla geçiş gösteren bir veneral hastalıktır. Topikal, immünoterapötik ve cerrahi yaklaşımlar en çok tercih edilen tedavi modaliteleridir. Hastalar ve Metodlar: GATA Genel Cerrahi Ana Bilim Dalı ile Deri ve Zührevi Hastalıkları Ana Bilim Dalı kliniklerinde 1990-2003 yılları arasında anogenital bölgede kondilomata aküminata tanısı konan 50 hastaya uygulanan tedavi yöntemleri retrospektif olarak incelendi. Olgular lezyonların genişliğine, lokalizasyon yerinin uygunluğuna göre medikal veya cerrahi yöntemler ile tedavi edilmiş, bazı olgularda, medikal tedaviye ek olarak koterizasyon uygulanmıştır. Bulgular: Çalışmaya dahil edilen 50 hastanın 45'i erkek, 5'i kadın hasta idi. Medikal tedavi uygulanan hastaların yaş ortalaması 29.1 $\pm$ 8.8 iken, cerrahi tedavi uygulananlarda 30.0 $\pm$ 9.2 idi. Medikal tedavi uygulanan hastalarda, ortalama takip süresi 20.0 $\pm$ 10.7 ay iken, cerrahi tedavi uygulanan hastalarda 24.0 $\pm$ 15.0 aydır. Olguların tamamı değerlendirildiğinde, medikal tedavi grubunda 6 olguda (%22.7) nüks saptanmış olup cerrahi tedavi uygulanan olgularda nüks tespit edilmemiştir. Sonuç: Genital siğillerin tedavisinde hastaya sağlanacak olan en iyi yarar hastalığın lokalizasyonu ve yaygınlığı ile birlikte hasta ve tedavi eden hekimin tercihine bağlı olmaktadır. Topikal ajanlar ile tedavi yaklaşımları, küçük boyutlu lezyonlarda kabul edilebilir rekürrens oranları ile hastaların büyük bir çoğunluğunda lezyonları ortadan kaldırmaktadır. Geniş boyutlu lezyonlarda cerrahi tedavi etkin yöntemdir.

🔖

Cite This Article

YAĞCI, G., KAYMAKÇIOĞLU, N., AKAR, A., ARDA, E., GÖRGÜLÜ, S., PEKER, Y., AKDENİZ, A., TUFAN, T. (2005). Treatment modalities in patients with condyloma acuminata of anogenital region. Gülhane Tıp Dergisi, Cilt: 47 - Sayı: 1, 29–33. https://ajindex.com/articles/225641

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Chang, G.J., Welton, M.L.: Condylomata Acuminata. Problems in Gen Surg 18[3], 55-64. 2001
  2. Beutner, K.R., Ferenczy, A.: Therapeutic approaches to genital warts. Am J Med.102:28- 37,1997
  3. Congilosi, S.M., Madoff, R.D.: Current therapy for recurrent and extensive anal warts. Dis Colon Rectum.38:1101-1107,1995
  4. Manzione, C.R., Nadal, S.R., Calore, E.E.: Postoperative follow-up of anal condylomata acuminata in HIV-positive patients. Dis Colon Rectum.46:1358-1365,2003
  5. Byars, R.W., Poole, G.V., Barber, W.H.: Anal carcinoma arising from condyloma acuminata. Am Surg.67:469-472,2001
  6. Chang, G.J., Berry, J.M., Jay, N., Palefsky, J.M., Welton, M.L.: Surgical treatment of high-grade anal squamous intraepithelial lesions: a prospective study. Dis Colon Rectum.45:453- 458,2002
  7. Lacey, C.J., Goodall, R.L., Tennvall, G.R., Maw, R., Kinghorn, G.R., Fisk, P.G., Barton, S., Byren. I.: Randomised controlled trial and economic evaluation of podophyllotoxin solution, podophyllotoxin cream, and podophyllin in the treatment of genital warts. Sex Transm Infect.79:270-275,2003
  8. De, Panfilis, G., Melzani, G., Mori, G., Ghidini, A., Graifemberghi, S.: Relapses after treatment of external genital warts are more frequent in HIVpositive patients than in HIV-negative controls. Sex Transm Dis.29:121-125,2002
  9. Coremans, G., Margaritis, V., Snoeck, R., Wyndaele, J., De, Clercq, E., Geboes, K.: Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata. Dis Colon Rectum.46: 1103-1108,2003
  10. Garland, S.M.: Imiquimod. Curr Opin Infect Dis.16:85-89,2003
  11. Chu, Q,D., Vezeridis, M.P., Libbey, N.P., Wanebo, H.J.: Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum.37:950-957,1994
  12. Uribe, N., Millan, M., Flores, J., Asencio, F., Diaz, F., Del, Castillo, J.R.: Excision and V-Y plasty reconstruction for giant condyloma acuminatum. Tech Coloproctol.8:99-101,2004.