Journals / Gülhane Tıp Dergisi / 2007 / Cilt: 49 - Sayı: 4

Photodynamic therapy with verteporfin in choroidal neovascularization developing due to age-related macular degeneration

Yaşa bağlı maküla dejenerasyonunda gelişen koroid neovasküler membranların verteporfin ile fotodinamik tedavisi

Pages
240–244
DOI
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⚡ TL;DR(Too Long; Didn't Read)

There was a statistically significant positive correlation between the initial and final best corrected visual acuities.

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Objective & Hypothesis:Photodynamic therapy with verteporfin in choroidal neovascularization developing due to age-related macular degeneration In this study it was aimed to evaluate our results of photodynamic therapy with verteporfin in subfoveal choroidal neovascular membranes developing due to age-related macular degeneration.
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Key Findings & Data:Seventy five eyes of the 65 patients diagnosed to have subfoveal choroidal neovascular membranes due to age-related macular degeneration between October 2004 and June 2006 were included in the study.
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Conclusion & Impact:There was a statistically significant positive correlation between the initial and final best corrected visual acuities.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Floresan anjiyografi · Koroidal neovaskülarizasyon · Maküler dejenerasyon

Abstract

Photodynamic therapy with verteporfin in choroidal neovascularization developing due to age-related macular degeneration In this study it was aimed to evaluate our results of photodynamic therapy with verteporfin in subfoveal choroidal neovascular membranes developing due to age-related macular degeneration. Seventy five eyes of the 65 patients diagnosed to have subfoveal choroidal neovascular membranes due to age-related macular degeneration between October 2004 and June 2006 were included in the study. Initial and last best corrected visual acuities of the cases, findings of ophthalmic examination and fundus fluorescein angiography were recorded. Cases were divided into three groups as predominantly classic, minimally classic and occult choroidal neovascular membranes on the basis of fundus fluorescein angiography findings. Mean age of the patients was 76.2±7.8 years, and 34 (52.3%) were female and 31 (47.7%) were male. Thirty four (45.3%), 14 (18.7%) and 27 (36%) of the cases were in the groups of predominantly classic, minimally classic and occult choroidal neovascular membranes, respectively, according to findings of fundus fluorescein angiography. Mean initial best corrected visual acuities according to Log Mar was -1.18±0.8 (range -2.6 to -0.1). Mean final best corrected visual acuities according to Log Mar was -1.19±0.8 (range -2.6 to 0). There were no statistically significant differences among the changes of mean visual acuity according to lesion types. There was a statistically significant positive correlation between the initial and final best corrected visual acuities.

Özet

Bu çalışmada yaşa bağlı maküla dejenerasyonunda gelişen subfoveal koroid neovasküler membranların tedavisinde verteporfin ile fotodinamik tedavi sonuçlarımızın değerlendirilmesi amaçlanmıştır. Ekim 2004 ile Haziran 2006 arasında yaşa bağlı maküla dejenerasyonu tanısı alan ve subfoveal koroid neovasküler membranlar tespit edilen 65 hastanın 75 gözü çalışma kapsamına alındı. Olguların başlangıç ve sonuç en iyi görme keskinliği, oftalmolojik muayene ve fundus flöresein anjiyografi bulguları kaydedildi. Olgular fundus flöresein anjiyografi bulgularına göre baskın klasik, minimal klasik ve gizli koroid neovasküler membran olmak üzere üç gruba ayrıldı. Olguların yaş ortalamaları 76.2±7.8 yıl idi ve 34'ü (%52.3) kadın, 31'i (%47.7) erkekti. Fundus flöresein anjiyografi bulgularına göre olguların 34'ü (%45.3) baskın klasik, 14'ü (%18.7) minimal klasik ve 27'si (%36.0) gizli koroid neovasküler membran özelliğindeydi. Başlangıç ortalama en iyi görme keskinliği Log Mar'a göre -1.18±0.8 idi (-2.6 ile -0.1 aralığında). Tedavi sonrası en iyi görme keskinliği Log Mar'a göre -1.19±0.8 idi (-2.6 ile 0 aralığında). Lezyon tipine göre ortalama görme keskinliği değişiklikleri arasında istatistiksel anlamlı farklılık bulunamadı. Başlangıç en iyi görme keskinliği ile sonuç en iyi görme keskinliği arasında istatistiksel olarak iyi düzeyde pozitif yönde anlamlı ilişki bulundu.

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Cite This Article

SAKIN, A., ERŞANLI, D., AYATA, A., ÜNAL, M. (2007). Photodynamic therapy with verteporfin in choroidal neovascularization developing due to age-related macular degeneration. Gülhane Tıp Dergisi, Cilt: 49 - Sayı: 4, 240–244. https://ajindex.com/articles/225583

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References (12)

  1. Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull World Health Organ 1995; 73: 115-121
  2. Pauleikhoff D. Neovascular age-related macular degeneration. Natural history and treatment outcomes. Retina 2005; 25: 1065-1084
  3. Sickenberg M. Early detection, diagnosis and management of choroidal neovascularization in age-related macular degeneration: the role of ophthalmologists. Ophthalmologica 2001; 215: 247-253
  4. Treatment of age-related macular degeneration with photodynamic therapy (TAP) study group. Photodynamic therapy of subfoveal choroidal neovascularization in agerelated macular degeneration with verteporfin. One-year result of 2 randomized clinical trials-TAP Report 1. Arch Ophthmol 1999; 117: 1329-1345
  5. Schmidt-Erfurth U, Michels S, Barbazetto I, Laqua H. Photodynamic effects on choroidal neovascularization and physiological choroid. Invest Ophthalmol Vis Sci 2002; 43: 830-841
  6. Blinder KJ, Blumenkranz MS, Bressler NM, et al. Verteporfin in photodynamic therapy (VIP) study group. Verteporfin therapy of subfoveal choroidal neovascularization pathologic myopia: two-year results of a randomized clinical trial. VIP report 3. Ophthalmology 2003; 110: 667-673
  7. Yetik H, Müftüoðlu G, Akar S, Aras C, Özkan Þ. Oküler fotodinamik tedavide 24 aylýk sonuçlarýmýz. Retina Vitreus 2005; 13: 173-178
  8. Karaçorlu M, Karaçorlu S, Özdemir H. Klasik koroid neovaskülarizasyonlu ve gizli koroid neovaskülarizasyonlu yaþa baðlý makula dejenerasyonu olgularýndaki fotodinamik tedavi uygulamasýnýn 12 aylýk takip sonuçlarý. Retina Vitreus 2003; 11: 13-18
  9. Altan T, Kapran Z, Yalçýn O, Acar N, Çakýr M, Ünver YB. Yaþa baðlý makula dejenerasyonununda subfoveal koroidal neovaskülarizasyonunu vertoporfin ile fotodinamik tedavisinin orta ve uzun dönem sonuçlarý. Retina Vitreus 2006; 14: 169-174
  10. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 1997; 104: 7-21
  11. Olsen TW, Feng X, Kasper TJ, Rath PP, Steuer ER. Fluorescein angiographic lesion type frequency in neovascular age-related macular degeneration. Ophthalmology 2004; 111: 250-255
  12. Treatment of age-related macular degeneration with photodynamic therapy (TAP) study group. Photodynamic therapy of subfoveal choroidal neovascularization in agerelated macular degeneration with Verteporfin. Two-year results of 2 randomized clinical trials. TAP report 2. Arch Ophthalmol 2001; 1