Journals / Gülhane Tıp Dergisi / 2007 / Cilt: 49 - Sayı: 2

Central corneal and retinal nerve fiber layer thickness in patients with diabetes mellitus

Diyabetes mellituslu olgularda santral kornea kalınlığı ve retina sinir lifi kalınlığı

Pages
91–95
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were not statistically significant differences between the diabetic patients and the control group on the basis of measurements of central corneal thickness and retinal nerve fiber layer thickness.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:It has been shown that diabetes mellitus and systemic hypertension each are the risk factors for high intraocular pressure.
📊
Key Findings & Data:Patients diagnosed to have diabetes mellitus type 2 (fasting glucose level ≥126 ml/dL) without systemic hypertension and glaucoma were enrolled in the study.
💡
Conclusion & Impact:There were not statistically significant differences between the diabetic patients and the control group on the basis of measurements of central corneal thickness and retinal nerve fiber layer thickness.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

It has been shown that diabetes mellitus and systemic hypertension each are the risk factors for high intraocular pressure. The aim of this study was to assess the correlation between glaucoma, and central corneal thickness and retinal nerve fiber layer thickness in patients with diabetes mellitus. Patients diagnosed to have diabetes mellitus type 2 (fasting glucose level ≥126 ml/dL) without systemic hypertension and glaucoma were enrolled in the study. The patients were divided into three groups according to their diabetes duration (0-5, 6-10 and 11- 15 years). Central corneal thickness measurements were made with Pacline Opticone Ultrasonic Pacimetry. Retinal nerve fiber layer thickness measurements were made with NFA II, GDx VCC. Data of the patients were compared with the findings of a control group consisting of healthy subjects. There were no significant differences between the control and other groups with respect to age and gender. Central corneal thickness was 544.17±37.95 in the control group, 543.89±33.37 in Group 1, 548.55±37.48 in Group 2, 552.11±32.53 in Group 3, and there were no significant differences between the control and other groups (p>0.05). There were also no significant differences between the control and other groups with respect to parameters such as TSNIT, SA, IA and NFI in the measurement of retinal nerve fiber layer thickness. There were not statistically significant differences between the diabetic patients and the control group on the basis of measurements of central corneal thickness and retinal nerve fiber layer thickness.

Özet

Diyabetes mellitus ve sistemik hipertansiyonun, yükselmiş göz içi basıncı için birer risk faktörü olduğu gösterilmiştir. Bu çalışmada diyabetes mellitusu olan hastalarda, santral kornea kalınlığı ve retina sinir lifi tabakası kalınlığı ölçülerek, glokom ile olan ilişkisi araştırılmıştır. Tip II diyabetes mellitus tanısı alan (açlık kan şekeri 126 mg/dL ve üzeri), sistemik hipertansiyonu ve glokomu olmayan olgular çalışmaya alındı. Diyabetli hastalar, diyabet süresi 0-5 yıl, 6-10 yıl, 11-15 yıl olmak üzere 3 gruba ayrıldı. Olguların santral kornea kalınlıkları Pacline Optikon Ultrasonik pakimetre cihazı ile ölçüldü. Retina sinir lifi kalınlığı ölçümü ise NFA II, GDx VCC cihazı ile yapıldı. Çalışmaya alınan olguların bulguları, sağlıklı bireylerden oluşan kontrol grubunun bulgularıyla karşılaştırıldı. Kontrol grubu ile diğer gruplar arasında yaş ve cins yönünden istatistiksel olarak anlamlı farklılık yoktu. Santral kornea kalınlığı kontrol grubunda 544.17±37.95, Grup I'de 543.89±33.37, Grup II'de 548.55±37.48, Grup III'de 552.11±32.53 idi ve kontrol grubu ile diğer gruplar arasında istatistiksel olarak anlamlı farklılık bulunamadı (p>0.05). Retina sinir lifi tabakası kalınlığı ölçümü açısından bakıldığında ise, TSNIT, SA, IA, NFI gibi parametreler incelendiğinde aynı şekilde kontrol grubu ile diğer gruplar arasında istatistiksel olarak anlamlı farklılık bulunamadı. Diyabetik hastalardaki santral kornea kalınlığı ve retina sinir lifi tabakası kalınlığı kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık göstermiyordu.

🔖

Cite This Article

ERGİN, A., GÜLLÜ, R., ÇAKMAK, Y., DURUKAN, A. H. (2007). Central corneal and retinal nerve fiber layer thickness in patients with diabetes mellitus. Gülhane Tıp Dergisi, Cilt: 49 - Sayı: 2, 91–95. https://ajindex.com/articles/225535

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Leung CK, Chan W, Chong KK, et al. Comparative study of retinal nerve fiber layer measurement by Stratus OCT and GDx VCC, I: correlation analysis in glaucoma.Invest Ophthalmol Vis Sci 2005; 46: 3214-3220
  2. Klein BE, Klein R, Jensen SC. Open angle glaucoma and older onset diabetes: The Beaver Dam Eye Study. Ophthalmology 1994; 101: 1173-1177
  3. Mitchell P, Smith W, Chey T, et al. Open angle glaucoma and diabetes: The Bluemauntains Eye Study, Australia. Ophthalmology 1977; 104: 712-718
  4. Lopes JM, Russ H, Costa VP. Retinal nerve fiber layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol 2002; 86: 725-728
  5. Chiara H, Matsuoka T, Ogura Y, et al. Retinal nerve fiber layer defects as an early manifestation of diabetic retinopathy. Ophthalmology 1993; 100: 1147-1151
  6. Varkonyi TT, Peto T, Degi R, et al. Impairment of visual evoked potentials: an early central manifestation of diabetik neuropathy? Diabetes Care 2002; 25: 1661- 1662
  7. Greenstein VC, Shapirove A, Zaidi Q, et al. Psychophysical evidence for post-reseptoral sensitivity loss in diabetes-. Invest Ophthalmol Vis Sci 1992; 33: 2781- 2790
  8. Amemiya T. Dark adaptation in diabetics. Ophthalmologica 1977; 174: 322-326
  9. Chiara E, Zhang S. Analysis of diabetic optic neuropathy with a topographic laser scanning system.Nippon Ganka Gakkai Zassi 1998; 102: 431-435
  10. Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991; 109: 77-83
  11. Gardner TW, Antonetti DA,Barber AJ, et al. Diabetic retinopathy: more than meets the eye.Surv Ophthalmol 2002; 47: 253-262
  12. Conceiçao LL, Bernardes RC,Abreu RF, et al. One-year followup of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative retinopathy. Arch Ophthalmol 2001; 119: 1469-1474
  13. Conceiçao LL, Bernardes RC, Figueira JP, et al. Three-year follow- up of blood-retinal barrier and retinal thickness alterations in patients with type 2 diabetes mellitus and mild nonproliferative retinopathy. Arch Ophthalmol 2004; 122: 211-217
  14. Ozdek S, Lonneville YH, Önol M, Yekin I, Hasanreisoğlu B. Assessment of nevre fiber layer in diabetic patients with scanning laser polarimetry. Eye 2002; 16: 761-765
  15. Takahashi H, Goto T, Shojı T, et al. Diabetes associated retinal nevre fiber damage evaluated with scanning laser polarimetry. Am J Ophthalmol 2006; 142: