Journals / Gülhane Tıp Dergisi / 2009 / Cilt: 51 - Sayı: 1

An in vivo model for angiogenesis: Chick chorioallantoic membrane

Anjiyogenezde bir in-vivo model: Civciv koriyoallantoik membran

Pages
67–69
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

That chick chorioallantoic membrane assay is cost-effective, simple, reliable and reproducible regarding angiogenic response, attracts investigators.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Angiogenesis is a biological process by which new capillaries are formed and it occurs in some physiological and pathological conditions.
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Key Findings & Data:Angiogenesis is controlled by the net balance between molecules that have positive and negative regulatory activity.
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Conclusion & Impact:That chick chorioallantoic membrane assay is cost-effective, simple, reliable and reproducible regarding angiogenic response, attracts investigators.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Angiogenesis is a biological process by which new capillaries are formed and it occurs in some physiological and pathological conditions. Angiogenesis is controlled by the net balance between molecules that have positive and negative regulatory activity. The process of building new blood vessels (angiogenesis) and controlling the propagation of blood vessels (anti-angiogenesis) are fundamental to human health. For this reason, the study of angiogenesis is an active area of research. In vitro models, although useful in delineating parts of this process, may not be representative of what occurs in vivo. The highly vascularized chick embryo chorioallantoic membrane model, which is being extensively used in the research of angiogenesis is a useful in vivo system. That chick chorioallantoic membrane assay is cost-effective, simple, reliable and reproducible regarding angiogenic response, attracts investigators.

Özet

Anjiyogenez, yeni kapiller oluşumu ile seyreden biyolojik bir süreçtir ve bazı fizyolojik ve patolojik durumlarda ortaya çıkmaktadır. Anjiyogenez pozitif ve negatif düzenleyici aktiviteye sahip moleküller arasındaki net dengeyle kontrol edilir. İnsan sağlığı açısından yeni damar oluşumu (anjiyogenez) ve kan damarlarının yayılımının kontrolü (anti-anjiyogenez) oldukça önemlidir. Bu nedenle, anjiyogenez aktif bir araştırma alanıdır. İn vitro modeller, bu süreci tarif etmede faydalı olsalar da, in vivo ne olduğunu yansıtmayabilir. Anjiyogenez araştırmalarında çok yaygın olarak kullanılan, yoğun vaskülarize civciv embriyo koriyoallantoik membran modeli, faydalı bir in vivo sistemdir. Civciv koriyoallantoik membran ölçümünün anjiyojenik yanıt açısından fiyat– etkin, basit, güvenilir ve tekrarlanabilir olması, araştırmacılar için çekici özellik taşımaktadır.

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Cite This Article

ÖZGÜRTAŞ, T. (2009). An in vivo model for angiogenesis: Chick chorioallantoic membrane. Gülhane Tıp Dergisi, Cilt: 51 - Sayı: 1, 67–69. https://ajindex.com/articles/225475

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References (14)

  1. Costa C, Soares R, Schmitt F. Angiogenesis: now and then. APMIS 2004; 112: 402-412
  2. Norrby K. In-vivo models of angiogenesis. J Cell Mol Med 2006; 10: 588-612
  3. Ribatti D, Vacca A, Presta M. The discovery of angiogenic factors: a historical review. Gen Pharmacol 2002; 35: 227-231
  4. Vallee BL, Riordan JF, Lobb RR, et al. Tumor-derived angiogenesis factors from rat Walker 256 carcinoma: an experimental investigation and review. Experientia 1985; 41: 1-15
  5. Auerbach R, Auerbach W, Polakowski I. Assays for angiogenesis: a review. Pharmac Ther 1991; 51: 1-11
  6. Auerbach R, Lewis R, Shinners B, Kubai L, Akhtar N. Angiogenesis assays: a critical overview. Clin Chem 2003; 49: 32-40
  7. Leng T, Miller JM, Bilbao V, Palanker DV, Huie P, Blumenkranz MS. The chick chorioallantoic membrane as a model tissue for surgical retinal research and simulation. Retina 2004; 24: 427-434
  8. Ribatti D, Nico B, Vacca A, Roncall L, Burri PH, Djonov V. Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and anti-angiogenesis in vivo. Anat Rec 2001; 264: 317-324
  9. Melkonian G, Munoz N, Chung J, Tong C, Marr R, Talbot P. Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by Ctochalasin D and Suramin. J Exp Zool 2002; 292: 241-254
  10. Hazel SJ. A novel early chorioallantoic membrane assay demonstrates quantitative and qualitative changes caused by antiangiogenic substances. J Lab Clin Med 2003; 141: 217-228
  11. Özgürtaş T, Tapan S, Akgül EÖ, Erbil MK. Angiogenezde kullanılan bir in-vivo model: civciv koryoallantoik membran (CAM). VII. Ulusal Klinik Biyokimya Kongresi, 19-22 Nisan 2007, Antalya. Kongre Özet Kitabı, P61
  12. Özgürtaş T, Avcı Ö, Erbil MK. Bilberry inhibits angiogenesis in chick chorioallantoic membrane. 8th World Congress for Microcirculation, 15-19 Agustos 2007, Milwaukee, USA. Kongre Özet Kitabı, 448
  13. Özgürtaş T. A novel approach at chick chorioallantoic membrane (CAM) model in angiogenesis. BIT 1st Annual World Cancer Congress, 14-19 October 2007, Beijing, China. Kongre Özet Kitabı, 119
  14. Durukan H, Özgürtaş T, Erbil MK, Mumcuoğlu T, Karagöz S. Bevakizumab ve pegaptanip sodyumun civciv koryoallantoik membran üzerine etkisi. Türk Oftalmoloji Derneği 41. Ulusal Kongresi, 30 Ekim-2 Kasım 2007, Antalya. Kongre Özet Kitabı, 277.