Journals / Gülhane Tıp Dergisi / 2010 / Cilt: 52 - Sayı: 3

The effects of chronic renal failure, dialysis and kidney transplantation on sexual and reproductive functions

Kronik böbrek yetmezliği, diyaliz ve böbrek naklinin cinsel ve üreme işlevleri üzerindeki etkileri

Pages
229–236
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article pathophysiology of sexual dysfunction is firstly reviewed, and later erectile dysfunction and its treatment are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The uremic milieu plays an important role in the development of sexual dysfunction in chronic renal failure.
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Key Findings & Data:High FSH and LH and low testosterone levels are reported in uremic men and testosterone level returns to normal after a successful kidney transplantation.
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Conclusion & Impact:In this article pathophysiology of sexual dysfunction is firstly reviewed, and later erectile dysfunction and its treatment are discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The uremic milieu plays an important role in the development of sexual dysfunction in chronic renal failure. High FSH and LH and low testosterone levels are reported in uremic men and testosterone level returns to normal after a successful kidney transplantation. Spermatogenic abnormalities and loss of libido and potency associated with a defect in testosterone biosynthesis have been reported in about half of hemodialysis patients. It is well established that libido and potency, which are of disorders of sexual dysfunction persisting during hemodialysis in men with uremia resolve after renal transplantation. In this article pathophysiology of sexual dysfunction is firstly reviewed, and later erectile dysfunction and its treatment are discussed.

Özet

Kronik böbrek yetmezliğinde cinsel işlev bozukluğunun ortaya çıkmasında üremik ortam önemli rol oynar. Üremik erkeklerde yüksek FSH, LH ve düşük testosteron seviyeleri bildirilmektedir ve başarılı böbrek nakli sonrası testosteron seviyesinin normal sınırlara geldiği anlaşılmıştır. Hemodiyaliz hastalarının yaklaşık yarısında, spermatogenik anormallikler ve testosteron biyosentezinde eksiklikle ilişkili libido ve potens kaybı meydana gelir. Üremik erkeklerde hemodiyalizin devamı boyunca sürekli olarak görülen cinsel işlev bozukluklarından libido ve potensin böbrek nakli sonrası geriye döndüğü ortaya konmuştur. Bu derlemede kronik böbrek yetmezliği hastalarında üreme işlevi yetersizliğinin patofizyolojisi öncelikle incelenmiş, sonra erektil işlev bozukluğu ve tedavisi tartışılmıştır.

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Cite This Article

ATEŞ, F. (2010). The effects of chronic renal failure, dialysis and kidney transplantation on sexual and reproductive functions. Gülhane Tıp Dergisi, Cilt: 52 - Sayı: 3, 229–236. https://ajindex.com/articles/225436

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References (16)

  1. Procci WR, Goldstein DA, Adestein J, Massry SG. Sexual dysfunction in the male patient with uremia: a reappraisal. Kidney Int 1981; 19: 317-323
  2. Chopp RT, Mendez R. Sexual function and hormonal abnormalities in uremic man on chronic dialysis and after renal transplantation. Fertil Steril 1978; 29:661-666
  3. Diemont WL, Vruggink PA, Meuleman EJ, Doesburg WH, Lemmens WA, Berden JH. Sexual dysfunction after renal replacement therapy. Am J Kidney Dis 2000;35: 845-851
  4. Rosas SE, Joffe M, Franklin E, et al. Association of decreased quality of life and erectile dysfunction in hemodialysis patients. Kidney Int 2003; 64: 232-238
  5. Holdsworth SR, de Kretser DM, Atkins RC. A comparison of hemodialysis and transplantation in reversing the uremic disturbance of male reproductive function. Clin Nephrol 1978; 10: 146-150
  6. Toorians AW, Janssen E, Laan E, et al. Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. Nephrol Dial Transplant 1997; 12: 2654-2663
  7. Holdsworth S, Atkins R, de Kretser D. The pituitarytesticular axis in men with chronic renal failure. N Engl J Med 1977; 296: 1245-1249
  8. Pezeskhi ML, Ghazizadeh S. Sexual and reproductive function in end-stage renal disease and effect of kidney transplantation. Asian J Androl 2008: 10; 441-446
  9. Hagen C, Olgaard K, McNeilly AS, Fisher R. Prolactin and the pituitary-gonadal axis in male uraemic patients on regular dialysis. Acta Endocrinol (Copenh) 1976; 82:29-38
  10. Handelsman DJ, Spaliviero JA, Turtle JR. Hypothalamic pituitary function in experimental uremic hypogonadism. Endocrinology 1985; 117: 1984-1995
  11. Handelsman DJ. Hypothalamic pituitary gonadal dysfunction in renal failure, dialysis and renal transplantation. Endocrinol Rev 1985; 6: 151-182
  12. Lim VS. Reproductive function in patients with renal insufficiency. Am J Kid Dis 1987; 9: 363-367
  13. Peces R, Horcajada C, Lopez-Novoa JM, Frutos MA, Casado S, Hernando L. Hyperprolactinemia in chronic renal failure. impaired responsiveness to stimulation and suppression. Normalization after transplantation. Nephron 1981; 28: 11-16
  14. Akbari F, Alavi M, Esteghamati A, et al. Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int 2003; 92: 281-283
  15. Rowe SJ, Montague DK, Steinmuller DR, Lakin MM, Novick AC. Treatment of organic impotence with penile prosthesis in renal transplant patients. Urology 1993; 41: 16-20
  16. NIH Consensus Conference. Impotence. N