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Journals / Gülhane Tıp Dergisi / 2011 / Cilt: 53 - Sayı: 3

Interference of HbF in HbA1c measurement by high performance liquid chromatography method: a case report

Yüksek basınçlı sıvı kromatografi (HPLC) tekniği ile HbA1c ölçümünde HbF’in interferansı: olgu sunumu

Tuncer ÇAYCI
Yasemin Gülcan KURT
İbrahim AYDIN
Halil YAMAN
Erdinç ÇAKIR
Pages
211–213
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, an interference which occured during measurement of HbA1c using high pressure liquid chromatography in blood sample belonging to a baby was emphasized.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hemoglobin A1c (HbA1c) measurements are widely used in the monitoring of blood glucose levels in patients with diabetes mellitus.
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Key Findings & Data:Different methods are used in the measurement of HbA1c.
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Conclusion & Impact:In this article, an interference which occured during measurement of HbA1c using high pressure liquid chromatography in blood sample belonging to a baby was emphasized.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hemoglobin A1c (HbA1c) measurements are widely used in the monitoring of blood glucose levels in patients with diabetes mellitus. Different methods are used in the measurement of HbA1c. It is possible to obtain false results in HbA1c measurement because of the effect of different interferences. In this article, an interference which occured during measurement of HbA1c using high pressure liquid chromatography in blood sample belonging to a baby was emphasized.

Özet

Diyabetes mellituslu hastaların kan glikoz düzeyinin izlenmesinde, hemoglobin A1c (HbA1c) ölçümleri yaygın olarak kullanılmaktadır. HbA1c ölçümünde değişik yöntemler kullanılmaktadır. HbA1c ölçümlerinde farklı interferanslar nedeniyle yanlış sonuçlar elde edilebilmektedir. Bu makalede, bir bebeğe ait kan örneğinde, yüksek basınçlı sıvı kromatografi tekniğiyle yapılan HbA1c ölçümü esnasında meydana gelen interferansa dikkat çekilmek istenmiştir.

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Cite This Article

ÇAYCI, T., KURT, Y. G., AYDIN, İ., YAMAN, H., ÇAKIR, E. (2011). Interference of HbF in HbA1c measurement by high performance liquid chromatography method: a case report. Gülhane Tıp Dergisi, Cilt: 53 - Sayı: 3, 211–213. https://ajindex.com/articles/225377

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References (7)

  1. Jeppsson JO, Kobold U, Barr J, et al. Approved IFCC reference method for the measurement of HbA1c in human blood. Clin Chem Lab Med 2002; 40: 78-89
  2. Goldstein D, Little R, Lorenz RA, et al. Tests of glycemia in diabetes. Diabetes Care 2004; 27: 1761-1773
  3. Thevarajah M, Nadzimah MN, Chew YY. Interference of hemoglobin A1c (HbA1c) detection using ionexchange high performance liquid chromatography (HPLC) method by clinically silent hemoglobin variant in University Malaya Medical Centre (UMMC)--a case report. Clin Biochem 2009; 42: 430-434
  4. Fairbanks VF, Klee GG. Biochemical aspects of hematology. In: Burtis CA, Ashwood ER (eds). Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: WB Saunders, 1999: 1642-1710
  5. Weykamp CW, Penders TJ, Muskiet FA, van der Slik W. Influence of hemoglobin variants and derivatives on glycohemoglobin determinations, as investigated by 102 laboratories using 16 methods. Clin Chem 1993; 39: 1717-1723
  6. Bry L, Chen PC, Sacks DB. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin. Clin Chem 2001; 47: 153-163
  7. Schnedl WJ, Krause R, Halwachs-Baumann G, Trinker M, Lipp RW, Krejs GJ. Evaluation of HbA1c determination methods in patients with hemoglobinopathies. Diabetes Care 2000; 23: 339-344.