Journals / Gülhane Tıp Dergisi / 2013 / Cilt: 55 - Sayı: 4

Horner sendromu: Tüp torakostominin oldukça nadir görülen bir komplikasyonu

Evaluation of cytotoxic effect of garlic on human gingival fibroblasts: A preliminary study

Pages
276–280
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts.
📊
Key Findings & Data:Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%.
💡
Conclusion & Impact:According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study we aimed to evaluate the cytotoxic effect of garlic extract on human gingival fibroblasts. Garlic extracts were prepared at 5 different concentrations as 12.5%, 6.25%, 3.12%, 1.5%, and 0.6%. Cytotoxic effects of garlic and clorhexidine gluconat (CH) on human gingival fibroblasts were evaluated by agar diffusion method at 24 h. Garlic extracts concentrations at 6.25, 3.12, and 1.5% were not found cytotoxic on human gingival fibroblasts, whereas concentration at 12.5% was found cytotoxic, this effect was found less cytotoxic than CH. According to results of this study we could suggest that Garlic would have a promising role in the future for oral health, if appropriate solutions can be prepared.

Özet

Çalışmamızda insan diş eti fibroblastları üzerine sarımsak özütünün sitotoksisitesi araştırıldı. %12.5, 6.25, 3.12, 1.5 ve 0.6’lık derişimlerde olmak üzere 5 farklı sarımsak çözeltisi hazırlandı. Klorheksidin glukonat ve sarımsağın insan dişeti fibroblastları üzerine olan sitotoksik etkileri 24. saatte agar difüzyon metodu ile değerlendirildi. % 6.25, 3.12 ve 1.5’lik derişimlerdeki sarımsak çözeltileri her hangi bir sitotoksik etki göstermemiştir. %12.5’luk derişimdeki sarımsak çözeltisi sitotoksik etki göstermiştir, bu etki klorheksidin glukonatın gösterdiğinden daha az bulunmuştur. Bu ön çalışmadan elde edilen verilere göre sarımsak çözeltisi ile hazırlanacak uygun solüsyonlar ağız sağlığının elde edilmesi yönünde gelecekte kullanılabilir.

🔖

Cite This Article

OZAN, F., ÖZDEM, M., OZAN, Ü., ŞENÇİMEN, M., AKIN, Z. P. (2013). Horner sendromu: Tüp torakostominin oldukça nadir görülen bir komplikasyonu. Gülhane Tıp Dergisi, Cilt: 55 - Sayı: 4, 276–280. https://ajindex.com/articles/225319

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Block E. The chemistry of garlic and onions. Sci Am 1985; 252: 114-119
  2. Bolton S, Nul G, Troetel WM. The medical uses of garlic-fact and fiction. J Am Pharm Assoc 1982; 22: 40- 43
  3. Benkeblia N. Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum). Lebensm Wiss u-Technol 2004; 37: 263-268
  4. Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics 2002; 27: 391-401
  5. Cavallito CJ, Bailey JH, Buck JS. The antibacterial principle of Allium sativum. III. Its precursor and “essential oil of garlic.” J Am Chem Soc 1945; 67: 1030
  6. Vaes LPJ, Chyka RA. Interactions of warfarin with garlic, ginger, ginkgo or ginseng: nature of the evidence. Annals of Pharmacotherapy 2000; 34: 478-482
  7. Koch HP. Garlic: The Science and Therapeutic Application of Allium Sativum L and Related Species. Baltimore, Williams & Wilkins. 1996
  8. Mar C, Bent S. An evidence-based review of the 10 most commonly used herbs. West J Med 1999; 171: 168-171
  9. Uchida Y, Takahashi T, Sato N. The characteristics of the antibacterial activity of garlic. Jpn J Antibiot 1975; 28: 638-642
  10. Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999; 2: 125-129
  11. Sokmen, A., Jones, B.M. & Erturk, M. The in vitro antibacterial activity of Turkish plants. J Ethnopharmacol 1999; 67: 79-86
  12. INTERNATIONAL STANDARD ISO 7405. Preclinical evaluation of biocompatibility of medical devices used in dentistry – Test Methods for Dental Materials. Geneva: International Organization for Standardization, 1997
  13. I N T E RNAT IO N A L S T A N DA R D I S O 1 0993–5. Biological Evaluation of Medical Devices – Part 5: tests for Cytotoxicity- in vitro methods. International Organization of Standardization, Geneva, Switzerland, 1999
  14. Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trappin of radicals and interaction with thiol containing proteins. Biochim Biophys Acta 1998; 1379: 233-244
  15. Gupta KC, Viswanthan R. Combined action of streptomycin and chloramphenicol with plant antivitocs against tubercle bacilli. I. Streptomycin and chloramphenical with cepharanthine. II. Streptomycin and allicin. Antibiot Chemother 1995; 5: 24-27
  16. Elnima El, Ahmed SA, Mekkawi AG, Mossa JS. The antimicrobial activity of garlic and onion extracts. Pharmazie 1983; 38: 747-8
  17. Groppo FC, ra