Journals / Gülhane Tıp Dergisi / 2014 / Cilt: 56 - Sayı: 1

Malign meme Iezyonlarındaki mikrokalsifikasyonların mammografik görünümünün histopatoloji ile korelasyonu

Correlation between the histopathology and the characteristics of mammographic microcalcifications in malignant breast lesions

Pages
27–31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Besides, it should be considered that spontenously resolving microcalsifications may be regarded as malign finding.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Our aim is to determine whether there is correlation between the histopathological diagnosis of malignant lesions with mammographic microcalcifications and the characteristics of microcalcifications.
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Key Findings & Data:Materials and methods: The patients who underwent mammographic study and the pathologic correlation of malignancy were reviewed retrospectively between October 2007 and April 2011. 43 malignant lesions with microcalcifications at mammography were included in the study.
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Conclusion & Impact:Besides, it should be considered that spontenously resolving microcalsifications may be regarded as malign finding.
🔬Design:Review & Systematic Survey
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Purpose: Our aim is to determine whether there is correlation between the histopathological diagnosis of malignant lesions with mammographic microcalcifications and the characteristics of microcalcifications. Materials and methods: The patients who underwent mammographic study and the pathologic correlation of malignancy were reviewed retrospectively between October 2007 and April 2011. 43 malignant lesions with microcalcifications at mammography were included in the study. The types and distribution of microcalcifications were assessed according to the ACR Bl-RADS (American College of Radiology Breast Imaging Reporting and Data System) classification. In the histopathological evaluation, histopathological type and nuclear grade of lesions and Ductal Carsinoma ln-situ subtypes were recorded. The Spearman correlation test and cross tables were used in the statistical analysis. Results: There were no significance between types of microcalcifications and histopathological type of lesions (p=0,124). There was no significant association between types of microcalcifications and Ductal Carsinoma ln-situ subtypes (p>0,05). Lesions that showed segmental distribution or pleomorphic microcalcifications were found in association with nuclear grade or 3. Pleomorphic microcalcifications were seen most frequently in Invasive Ductal Carcinoma (21/26). Besides, statistically significant correlation was found between the rate of in situ foci in invasive ductal cancer and the microcalcification types (p 0,044). Since the “r" value was determined as “-0,52", strong inverse correlation was determined between rate of DCIS and the microcalcification types. Conclusion: The characteristics of microcalcifications do not clearly indicate the histopathological type. Besides, it should be considered that spontenously resolving microcalsifications may be regarded as malign finding.

Özet

Amaç: Bu çalışmadaki amacımız, mikrokalsifikasyon içeren malign lezyonların histopatolojisi ile mikrokalsitikasyonların mamografik özellikleri arasında korelasyon olup olmadığını saptamaktır. Gereç ve Yöntem: Ekim 2007 ve Nisan 2011 tarihleri arasında, radyoloji servisimize başvuran mammografide malignite düşünülen ve patolojide malignite saptanan hastalar retrospektif olarak incelendi. Patolojisi malign çıkan ve mammografide mikrokalsifikasyon içeren 43 lezyon çalışmaya dahil edildi. Mikrokalsifikasyonların dağılımları ve tipleri ACR Bl-RADS (American College of Radiology Breast Imaging Reporting and Data System) sınıflamasına gore yapıldı. Histopatolojik değerlendirmede, lezyonların histolojik tipi ve nükleer derecesi ile duktal karsinoma in--situ (DKİS) tipleri kaydedildi. İstatistiksel analizde Spearman korelasyon testi ve çapraz tablolar kullanıldı. Bulgular: Çalışmada mikrokalsifikasyon içeren malign lezyonlarda mammografik mikrokalsifikasyonların tipi ile lezyonların histopatolojileri arasında istatistiksel anlamlı ilişki bulunmadı (p=0,124). Duktal karsinoma in--situ büyüme paternleri ve lezyonların nükleer derecesi ile mikrokalsifikasyonların tipleri arasında da anlamlı ilişki saptanmadı (p>0,05). Segmental dağılım gösteren lezyonlar nükleer derece--2 veya ile birliktelik gösterdiği bulundu. İnvaziv duktal karsinomda en sık pleomorfik mikrokalsifikasyon saptandı (21/26). Bunun yanında, invaziv duktal karsinomlardaki in-situ fokusların oranı ile mikrokalsifikasyonlann tipleri arasmda istatistiksel anlamlı ters korelasyon bulundu (p 0,044). 'r' değeri "-0,52" olup DKIS oranı ile mikrokalsifikasyon tipleri arasında ters yönde ciddi korelasyon mevcuttu. Sonuç: Malign meme lezyonları içerisindeki mikrokalsifikasyonların özellikleri lezyonların histopatolojik tipini belirlemez. Bunun yanında, spontan ortadan kalkan mikrokalsifikasyonların malign bir bulgu olabileceği bilinmelidir.

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Cite This Article

SİVRİOĞLU, A. K., BAŞEKİM, Ç., MUTLU, H., SÖNMEZ, G., SAGLAM, M., ÖZTÜRK, E., ÖZCAN, Ü. A., ATASOYL, M. M. (2014). Malign meme Iezyonlarındaki mikrokalsifikasyonların mammografik görünümünün histopatoloji ile korelasyonu. Gülhane Tıp Dergisi, Cilt: 56 - Sayı: 1, 27–31. https://ajindex.com/articles/225307

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