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Journals / Gülhane Tıp Dergisi / 2018 / Cilt: 60 - Sayı: 3

Pre-transplant low paratyroid hormone level: A risk factor for post-transplant osteoporosis and arterial stiffness

BAHAR GÜRLEK DEMİRCİ
Emre TUTAL
Mehtap ERKMEN
Zeynep BAL
Orhan GULİYEV
Turan ÇOLAK
Siren SEZER
Pages
107–111
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

An increase in post-transplant PTH is associated with graft dysfunction and vascular stiffness that point out the importance of close follow-up and improve the PTH levels after renal transplantation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives:Arterial stiffness is an early marker of arterial calcification.
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Key Findings & Data:Patients were divided into two groups according to pre-transplant PTH levels; patients with low PTH group (group 1; PTH 100 pg/ml, n: 59).
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Conclusion & Impact:An increase in post-transplant PTH is associated with graft dysfunction and vascular stiffness that point out the importance of close follow-up and improve the PTH levels after renal transplantation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives:Arterial stiffness is an early marker of arterial calcification. Adynamic bone disease is associated with microinflammation. The aim of this study is to evaluate the relationship between pre-transplant bone activity and post-transplant osteoporosis and arterial stiffness in kidney transplant recipients. Methods:One hundred and fifty kidney transplant recipients were enrolled into our study. All patients’ pre and post-transplant PTH levels, post-transplant lumbar t-scores and pulse wave velocity (PWv) were cross sectionally analyzed. Patients were divided into two groups according to pre-transplant PTH levels; patients with low PTH group (group 1; PTH 100 pg/ml, n: 59). Results:Serum PTH levels were slightly increased or stable after transplantation in group 1. In group 2; serum PTH levels was significantly decreased in 76 % of patients; however 24 % of group 2 patients had increased PTH after transplantation. In both groups, an increase in post-transplant PTH >30% was associated with higher serum creatinine and lower GFR levels and higher PWv. The factors influencing lumbar t-score were pre-transplant PTH, age and duration of hemodialysis. Pre-transplant PTH levels, lumbar t-score, age and duration after transplantation were detected as major determinants of PWv. Conclusions:Pre-transplant low serum PTH level is an important predictor for post-transplant osteoporosis and arterial stiffness. An increase in post-transplant PTH is associated with graft dysfunction and vascular stiffness that point out the importance of close follow-up and improve the PTH levels after renal transplantation.

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Cite This Article

DEMİRCİ, B. G., TUTAL, E., ERKMEN, M., BAL, Z., GULİYEV, O., ÇOLAK, T., SEZER, S. (2018). Pre-transplant low paratyroid hormone level: A risk factor for post-transplant osteoporosis and arterial stiffness. Gülhane Tıp Dergisi, Cilt: 60 - Sayı: 3, 107–111. https://ajindex.com/articles/225259

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