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Journals / Genel Tıp Dergisi / 1997 / Cilt: 7 - Sayı: 3

Progesterone receptors in hyperplastic and carcinomatous endometria

Endometrial hiperplazi ve adenokarsinomlarda progesteron reseptörlerinin durumu

YAŞAR ÜNLÜ
Kemal BEHZATOĞLU
İlyas ÖZARDALI
Rızvan T. ORHA
Pages
117–120
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Evaluating estrogen receptors in the cases of endometrial adenocarcinoma can be helpful for selecting treatment method.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to compare characteristics of estrogen receptors (ER) in endometrium of cases of endometrial hyperplasia and adenocarcinoma.
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Key Findings & Data:Methods: 15 cases with simple endometrial hyperplasia and 15 cases with grade I endometrial adenocarcinoma were evaluated.
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Conclusion & Impact:Conclusion: Evaluating estrogen receptors in the cases of endometrial adenocarcinoma can be helpful for selecting treatment method.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to compare characteristics of estrogen receptors (ER) in endometrium of cases of endometrial hyperplasia and adenocarcinoma. Methods: 15 cases with simple endometrial hyperplasia and 15 cases with grade I endometrial adenocarcinoma were evaluated. Specific monoclonal mouse antibody against estrogen receptor was used with peroxidase-antiperoxidase technique to localize estrogen receptors in paraffin embedded sections. Results: Specific staining for ER was limited to nuclei; no specific cytoplasmic staining was observed. ER was positive in the nuclei of epithelial cells in all of the patients with endometrial hyperplasia and in 80% of the patients with endometrial adenocarcinomas. In both groups, ER was less positive in the nuclei of stromal cells than in the nuclei of epithelial cells. Conclusion: Evaluating estrogen receptors in the cases of endometrial adenocarcinoma can be helpful for selecting treatment method.

Özet

Amaç: Bu çalışmada endometrial hiperplazi ve endometrial adenokarsinom teşhisi konulmuş vakalarda endometriumdaki östrojen reseptörlerinin (ER) özelliklerini karşılaştırmayı amaçladık. Yöntem: Basit tipte endometrial hiperplazi tanısı almış 15 vaka ile iyi diferansiye (greyd I) endometrial adenokarsinom tanısı almış 15 vakada peroksidaz-antiperoksidaz metodu ile parafin blok kesitlerine spesifik fare monoklonal ER antikorları uygulandı ve dokulardaki ER'leri araştırıldı. Bulgular: ER'lerin spesifik boyanması sadece çekirdekte sınırlı idi; sitoplazmada boyanma tespit edilmedi. Endometrial hiperplazi vakalarının tamamında epitel hücrelerinin çekirdeklerinde ER pozitifliği mevcut iken bu oran endometrial adenokarsinom vakalarında % 80 olarak bulundu. Her iki grupta da stromal hücrelerde epitel hücrelerine göre daha düşük derecede ER pozitifliği mevcuttu. Sonuç: Endometrial adenokarsinom vakalarında steroid reseptörlerinin durumunun değerlendirilmesi hastaya uygulanacak tedavi yönteminin seçilmesine yandımcı olabilir.

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Cite This Article

ÜNLÜ, Y., BEHZATOĞLU, K., ÖZARDALI, İ., ORHA, R. T. (1997). Progesterone receptors in hyperplastic and carcinomatous endometria. Genel Tıp Dergisi, Cilt: 7 - Sayı: 3, 117–120. https://ajindex.com/articles/225196

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