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Journals / Genel Tıp Dergisi / 2000 / Cilt: 10 - Sayı: 1

İnvestigation of glutathion S-transferase (GST) isoenzymes in various cancer cases

Glutatyon S-transferaz (GST) izoenzimlerinin çeşitli kanser vakalarında araştırılması

MEHMET AKÖZ
HÜSAMETTİN VATANSEV
MEHMET GÜRBİLEK
İdris AKKUŞ
Celalettin VATANSEV
Bünyamin KAPTANOĞLU
Pages
1–6
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: GST-p a is marker for gastrointestinal tractus, stomach and the liver cancers, and it is thought that the absence of GST-m may create a risk for cancer.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, investigation of serum GST-a, GST-p and GST-m of cancer patients and healthy controls were aimed.
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Key Findings & Data:Methods: This study was carried out on 66 (22 female, 44 male) cancer patients aged 29 to 90 (57±13) years and 32 (16 female,16 male) healthy subjects aged 23 to 59 (36±11) years.
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Conclusion & Impact:Conclusion: GST-p a is marker for gastrointestinal tractus, stomach and the liver cancers, and it is thought that the absence of GST-m may create a risk for cancer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Glutatyon transferaz · Tümör belirteci · biyolojik

Abstract

Objective: In this study, investigation of serum GST-a, GST-p and GST-m of cancer patients and healthy controls were aimed. Methods: This study was carried out on 66 (22 female, 44 male) cancer patients aged 29 to 90 (57±13) years and 32 (16 female,16 male) healthy subjects aged 23 to 59 (36±11) years. Results: GST-a and GST-p levels of the patients with gastrointestinal tractus, liver, stomach and other type of cancers and of the control group were found to be 5.60±3.74 ng/ml and 37.24±10.74 ng/ml, 6.20±2.56 ng/ml and 35.33±9.57 ng/ml, 5.73±4.91 ng/ml and 39.77±13.18 ng/ml, 4.62±3.46 ng/ml and 22.99±13.46 ng/ml, 4.77±3.24 ng/ml and 23.47±9.97 ng/ml, respectively. The GST-m was negative on 59.52 % of the cancer patients. There was no significant difference between GST-a level of the control group and cancer patients whereas the increase of GST-p level of the patients with gastrointestinal tractus, liver and stomach cancer groups was statistically significant. Conclusion: GST-p a is marker for gastrointestinal tractus, stomach and the liver cancers, and it is thought that the absence of GST-m may create a risk for cancer.

Özet

Amaç: Bu çalışmada glutatyon S-transferaz (GST) izoenzimlerinden GST-a, GST-p, GST-m’nin kanser hastaları ve sağlıklı kontrollerde araştırılması amaçlarmıştır. Yöntem: 29-90 (57±13) yaşları arasında 66 (22 kadın, 44 erkek) kanserli hasta ile yaşları 23-59 (36±11) arasında 32 (16 kadın,16 erkek) sağlıklı kişide GST-a, GST-p ve kanserli hastalarda GST-m düzeyleri araştırıldı. Bulgular: Kanser vakalarında sırasıyla GST-a ve GST-p değerleri gastrointestinal sistem (GİS) kanserlerinde 5.60±3.74 ng/ml ve 37.24±10.74 ng/ml, karaciğer kanserinde 6.20±2.56 ng/ml ve 35.33±9.57 ng/ml, mide kanserinde 5.73±4.91 ng/ml ve 39.77±13.18 ng/ml, diğer kanserlerde 4.62±3.46 ng/ml ve 22.99±13.46 ng/ml, kontrol grubunda ise 4.77±3.24 ng/ml ve 23.47±9.97 ng/ml olarak bulundu. GST-m düzeyleri ise kanserli hasta grubunda % 59.52 oranında negatif olarak belirlendi. Tüm hasta grupları ile kontrol grubuna ait GST-a değerleri arasında istatistiksel olarak önemli bir fark bulunmazken, GST-p düzeyleri arasında önemli fark olduğu görüldü. Sonuç: GST-p nin özellikle gastrointestinal sistem, mide ve karaciğer kanserlerinin teşhisinde önemli bir belirleyici olabileceği, GST-m yokluğunun ise kanser açısından risk faktörü oluşturabileceği kanaatine varıldı.

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Cite This Article

AKÖZ, M., VATANSEV, H., GÜRBİLEK, M., AKKUŞ, İ., VATANSEV, C., KAPTANOĞLU, B. (2000). İnvestigation of glutathion S-transferase (GST) isoenzymes in various cancer cases. Genel Tıp Dergisi, Cilt: 10 - Sayı: 1, 1–6. https://ajindex.com/articles/225125

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