Journals / Genel Tıp Dergisi / 2014 / Cilt: 24 - Sayı: 3

Current status of brachytherapy in gynecological tumors: Brachytherapy in gynecological tumors

Jinekolojik tümörlerde brakiterapideki güncel gelişmeler

Pages
118–129
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Image-guided adaptive brachytherapy, which has recently introduced to the treatments of gynecological malignancies, is another method that pro- vides significant improvements in the treatment of gynecological tumors

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Brachytherapy (BRT) has a very important role in the treatment of gynecological tumors.
📊
Key Findings & Data:The most important advantage of brachyt- herapy is ability to apply higher doses to the tumors whereas sparing surrounding critical tissues.
💡
Conclusion & Impact:Image-guided adaptive brachytherapy, which has recently introduced to the treatments of gynecological malignancies, is another method that pro- vides significant improvements in the treatment of gynecological tumors
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Brachytherapy (BRT) has a very important role in the treatment of gynecological tumors. The most important advantage of brachyt- herapy is ability to apply higher doses to the tumors whereas sparing surrounding critical tissues. BRT can be used alone after surgery in and in conjunction with external beam radiotherapy in early stage and advanced stage endometrial cancer patients respectively. The treatment modality for cervical cancer depends on the stage of the disease. Radiotherapy is accepted as the primary treatment modality in locally advanced disease, whereas in early stage disease it is accepted as adjuvant treatment after surgery. Radiotherapy can be a curative treatment option in locally advanced cervical cancer patients in accordance with the advantages of intracavitary BRT. Three-dimensional BRT has becoming widely used in the treatment of gynecological tumors. Three-dimensional BRT provides conformal dose distribution to the target volume while sparing nearby organs including the rectum and the bladder. Image-guided adaptive brachytherapy, which has recently introduced to the treatments of gynecological malignancies, is another method that pro- vides significant improvements in the treatment of gynecological tumors

Özet

Jinekolojik tümörlerin tedavisinde brakiterapi (BRT) çok önemli bir role sahiptir. BRT'nin en büyük avantajı tümörlü dokulara yük- sek doz radyoterapi uygularken çevre kritik dokuların korunabilmesidir. Endometriyum kanserinin tedavisinde cerrahi sonrasında erken evre hastalıkta tek başına, ileri evre hastalıkta ise eksternal radyoterapi ile birlikte kullanılabilmektedir. Serviks kanserinde ise seçilecek olan tedavi modalitesi hastalığın evresine bağlı olarak değişmektedir. BRT, eksternal radyoterapi ile birlikte erken evrelerde tek başına ya da cerrahiye adjuvan olarak uygulanabilirken lokal ileri evre hastalarda kemoradyoterapi primer tedavi modalitesi olarak kabul edilmiştir. Lokal ileri evre serviks kanserinde radyoterapinin küratif bir tedavi seçeneği olması intrakaviter BRT'nin sağladığı avantajlar doğrultusunda başarılabilmektedir. Jinekolojik tümörlerde üç boyutlu BRT son yıllarda giderek yaygınlaşan bir tedavi seçeneğidir. Üç-boyutlu BRT ile rektum ve mesane gibi kritik organlar daha iyi korunurken ve hedef hacime konformal bir doz dağılımı sağlanmaktadır. Görüntü kılavuzluğunda yapılan adaptif BRT jinekolojik tümörlerde son zamanlarda kullanılmaya başlanan ve bu hastaların tedavisinde önemli gelişmeler ve kolaylıklar sağlayan bir diğer yöntemdir

🔖

Cite This Article

YAVAŞ, G., YAVAŞ, Ç. (2014). Current status of brachytherapy in gynecological tumors: Brachytherapy in gynecological tumors. Genel Tıp Dergisi, Cilt: 24 - Sayı: 3, 118–129. https://ajindex.com/articles/225091

References (11)

  1. Brenner DJ, Williamson JF: Physics and biology of brachytherapy. In: principles and practice of radiation oncology. 5. Baskı, Perez C.A ve Bradly L.W. sayfa 423-75, Lippincott Williams& Wilkins, Philadelphia-New York, 2008.
  2. AAPM, Code of practice for brachytherapy physics: Report of the AAPM Radiation Therapy Committee Task Group no.56. Med Phys 1997;24:1557-98.
  3. Pierquin P, Wilson JF, Chassagne D. Modern Brachytherapy. Ma- son Publishing USA, Inc. (1987).
  4. Nag S, Owen JB, Ferman N et al. Survey of brachytherapy practice in the United States: a report of the Clinical Research Committe of the American Endocurietherapy Society.Int J Radiat Oncol Biol Phys 1995;31:103-7. ICRU. Dose and volume specification for reporting intracavitary therapy in gynecology: Report 38. Bethesda MD. International Commission of Radiation Units and Measurements, 1985.
  5. Grigsby PW, Perez CA, Camel HM et al. Stage II carcinoma of the endometrium: Results of therapy and prognostic factors. Int J Ra- diat Oncol Biol Phys 1985;11:1915.
  6. Papavasilious C, Yiogarakis D, Pappa J et al. Treatment of cervical carcinoma by total hysterectomy and postoperative external irra- diation. Int. J radiat Oncol Biol Phys 1980;6:871-4.
  7. Perkins PL, Chu AM, Jose B et al: Posthysterectomy megavoltage irradiation in the treatment of cervical carcinoma. Gynecol Oncol 1984;17:340-8. Deeks Emma. Local Therapy in endometrial cancer: evidence based review. Current Opinion in Oncology 2007;19:512-5.
  8. Shaeffer DT, Randall ME. Adjuvant radiotherapy in endometrial carcinoma. Oncologist 2005;10:623-31.
  9. Kong A, Johnson N, Cornes P, et al. Adjuvant radiotherapy for stage I endometrial cancer. Cochrane Database Syst Rev 2007:CD003916. Nout RA, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ et al. Quality of life after pelvic radiotherapy or vaginal brachytherapy for endo- metrial cancer: First results of the randomized PORTEC-2 Trial. J Clin Oncol 2009;27:3547-56.
  10. Aalders J, Abeler V, Kostad P et al. Postoperative external irradia- tion and prognostic parameters in stage I endometrial carcinoma: Clinical and histopathologic study of 540 patients. Obstet Gynecol 1980;56:419-27. Creutzberg CL, van Putten WL, Koper PC et al. The morbidity of treatment for patients with stage I endometrial cancer: Re- sults from a randomised trial. Int. J Radiot Oncol Biol Pyhs 2001; 51:1246-1255.
  11. Orton J, Blake P et al. Adjuvant external beam radiotherapy (EBRT) in the treatment of endometrial cancer. Results of the ran- domised MRC ASTEC and NCIC