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Journals / Genel Tıp Dergisi / 2000 / Cilt: 10 - Sayı: 4

The relationships between serum IGF-I (insulin like growth factor-I) levels and some biochemical parameters in the patients with obstructive coronary artery disease

Tıkayıcı koroner arter hastalarında serum IGF-I düzeyi ve bazı parametrelerle ilişkisi

Esma ÖZTEKİN
Bayram KORKUT
Mehmet GÜRBİLEK
Ali ÖZEREN
Ali Muhtar TİFTİK
Pages
171–176
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: IGF-I may be important in relations with CAD and a sign of taking a place in regulation of lipid levels along with GH.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the relationships between levels IGF-I and levels of total protein, albumin, uric acid, triglyceride, total cholesterol, HDL-cholesterol, age, WHR (waist-hip ratio), BMI (body mass index), the measurement of waist in the patients with obstructive coronary artery disease.
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Key Findings & Data:Methods:12 people (7 male, 5 female) with presence of negative exercise test as a control group and 12 people (7 male, 5 female) with presence of pozitive exercise test, obstructive coroner stenoses >50% as a test group were included.
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Conclusion & Impact:Conclusion: IGF-I may be important in relations with CAD and a sign of taking a place in regulation of lipid levels along with GH.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Trigliseridler · Albüminler · Vücut yapısı

Abstract

Objective: To investigate the relationships between levels IGF-I and levels of total protein, albumin, uric acid, triglyceride, total cholesterol, HDL-cholesterol, age, WHR (waist-hip ratio), BMI (body mass index), the measurement of waist in the patients with obstructive coronary artery disease. Methods:12 people (7 male, 5 female) with presence of negative exercise test as a control group and 12 people (7 male, 5 female) with presence of pozitive exercise test, obstructive coroner stenoses >50% as a test group were included. Results: In the test group IGF-I levels (122±47.43 ng/ml) were significantly lower than the control group (180±48.15 ng/ml). Also, the measurement of IGF-I levels in male test group (124.5±43.07 ng/ml) were significantly lower than the control group (185.5±56.68 ng/ml). In test group of female, IGF-I levels were (118.1±58.09 ng/ml) also lower than the levels in control group (172.1±37.75 ng/ml), but not significantly. In test group the pozitive correlations between IGF-I and HDL-cholesterol were found. Uric acid, triglyceride, total cholesterol and HDL-cholesterol levels were similarly in test and control groups, but in total and male test groups the levels of albumin were lower than the control groups. Conclusion: IGF-I may be important in relations with CAD and a sign of taking a place in regulation of lipid levels along with GH.

Özet

Amaç: Tıkayıcı koroner hastalarında serum IGF-I ile total protein, albumin, ürik asit, trigliserit, total kolesterol, HDL-Kolesterol, yaş, VKİ (vücut kütle indeksi), bel-kalça oranı (BKO) ve bel ölçüsü (BÖ) arasındaki ilişkiyi belirlemek. Yöntem: Çalışmada efor testi negatif olan 12 vaka (7 erkek, 5 kadın) kontrol, efor testi pozitif ve tıkayıcı koroner stenozu >% 50 olan 12 vaka (7 erkek, 5 kadın) ise deneme grubu olarak alındı. Bulgular: Deneme grubunda IGF-I düzeyi (122±47.43 ng/ml) kontrol grubuna göre (180±48.15 ng/ml) düşüktü. Erkeklerde IGF-I düzeyi deneme grubunda (124.5±43.07 ng/ml) kontrol grubundan (185.5±56.68 ng/ml) düşük iken; kadınlarda IGF-I düzeyi yönünden deneme (118.1±58.09 ng/ml) ve kontrol (185.5±56.68 ng/ml) grupları arasındaki fark önemsizdi. Deneme grubunda IGF-I ile HDL-kolesterol arasında pozitif korelasyon gözlendi. Ürik asit, trigliserit, total kolesterol ve HDL-kolesterol düzeyleri yönünden deneme ve kontrol grupları arasında önemli fark yoktu. Albumin düzeyleri, total deneme grubunda ve erkeklerde kontrol grubuna göre düşük bulundu. Sonuç: KAH ile ilişkiler yönünden ve GH’nun yanında IGF-I’in de lipid düzeylerinin regülasyonlarında yer alabileceğinin belirtisi olabilmesi açısından önemli bir sonuç olduğu kanaatine varıldı.

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Cite This Article

ÖZTEKİN, E., KORKUT, B., GÜRBİLEK, M., ÖZEREN, A., TİFTİK, A. M. (2000). The relationships between serum IGF-I (insulin like growth factor-I) levels and some biochemical parameters in the patients with obstructive coronary artery disease. Genel Tıp Dergisi, Cilt: 10 - Sayı: 4, 171–176. https://ajindex.com/articles/225076

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