Journals / Gülhane Tıp Dergisi / 2012 / Cilt: 54 - Sayı: 3

A case of acute pancreatitis developing due to use of valproic acid

Valproik asid kullanımına bağlı bir akut pankreatit olgusu

Pages
236–238
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In acute pancreatitis developing due to the use of valproic acid, early diagnosis with prompt discontinuation of the drug and symptomatic supportive treatment are sufficient.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Acute pancreatitis is a serious clinical picture rarely seen in children.
📊
Key Findings & Data:An 11-year-old boy was admitted because of abdominal pain and bilious vomitting.
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Conclusion & Impact:In acute pancreatitis developing due to the use of valproic acid, early diagnosis with prompt discontinuation of the drug and symptomatic supportive treatment are sufficient.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · İlaç toksisitesi · Erkek

Abstract

Acute pancreatitis is a serious clinical picture rarely seen in children. The most common causes are drugs, blunt trauma, anatomic abnormalities and biliary pathologies. Acute pancreatitis should be considered in patients presenting with severe abdominal pain, bilious vomiting, abdominal distention and fever. In this article a child in whom acute pancreatitis developed due to the use of valproic acid is presented and discussed. An 11-year-old boy was admitted because of abdominal pain and bilious vomitting. He was under valproic acid treatment with a dose of 40 mg/kg/day for 24 months for epilepsy. The diagnosis of acute pancreatitis was established under the results of physical examination and laboratory investigations. Complaints of the patient gradually decreased with supportive treatment and the cessation of valproic acid, and a complete healing was achieved in a week. Acute pancreatitis due to valproic acid has been rarely reported in the literature. In acute pancreatitis developing due to the use of valproic acid, early diagnosis with prompt discontinuation of the drug and symptomatic supportive treatment are sufficient.

Özet

Akut pankreatit çocuklarda nadir rastlanan ciddi bir klinik tablodur. En sık nedenleri ilaçlar, künt travma, anatomik bozukluklar ve biliyer patolojilerdir. Akut pankreatit şiddetli karın ağrısı, safralı kusma, batın distansiyonu, ateş bulgularıyla gelen hastalarda düşünülmelidir. Bu makalede valproik asid kullanımına bağlı akut pankreatit gelişen bir çocuk hasta sunulmuş ve tartışılmıştır. On bir yaşında erkek hasta, karın ağrısı ve safralı kusma nedeniyle getirildi. Hasta epilepsi tanısıyla 24 aydır 40 mg/kg/gün dozunda valproik asid tedavisi almaktaydı. Fizik muayene bulguları ve laboratuvar incelemeleri sonucunda akut pankreatit tanısı konuldu. Valproik asid kesilip, semptomatik tedavi uygulanan hastanın şikayetleri tedricen azaldı ve bir hafta içinde tam iyileşme sağlandı. Valproik aside bağlı akut pankreatit literatürde nadiren bildirilmiştir. Valproik asid kullanımı nedeniyle oluşan akut pankreatitte, erken tanı konularak, valproik asidin kesilmesi ve semptomatik destek tedavisi yeterlidir.

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Cite This Article

SARI, E., GÜNEŞ, Ö., BALAMTEKİN, N., ÜNAY, B. (2012). A case of acute pancreatitis developing due to use of valproic acid. Gülhane Tıp Dergisi, Cilt: 54 - Sayı: 3, 236–238. https://ajindex.com/articles/224962

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