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Journals / Genel Tıp Dergisi / 2000 / Cilt: 10 - Sayı: 3

Analysis of medroxyprogesterone acetate and dydrogesterone effects on rat endometrium

Medroksiprogesteron asetat ve dydrogesteronun rat endometriumu üzerine etkilerinin değerlendirilmesi

Mine KAYMAKÇI
Ali ACAR
Metin ÇAPAR
Ayfer BALA
Cemalettin AKYÜREK
Pages
121–126
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion dydrogesterone can be used instead of medroxyprogesterone acetate..

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To compare the effect of medroxyprogesterone acetate and dydrogesterone on rat endometrium.
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Key Findings & Data:Method: 28 rats (species of wistar) were used in this study .
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Conclusion & Impact:In conclusion dydrogesterone can be used instead of medroxyprogesterone acetate..
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sıçanlar · Karşılaştırmalı çalışma · Didrogesteron

Abstract

Objectives: To compare the effect of medroxyprogesterone acetate and dydrogesterone on rat endometrium. Method: 28 rats (species of wistar) were used in this study . Rats were divided into 3 groups.Group A (10 rats) was given 1 mg medroxyprogesterone acetate per day,group B (ten rats) was given 1 mg D per day orally for twenty days. Group C (8 rats) was not given any drug. At the end of twenty days,pathological examination of rat endometrium was done Results : If medroxyprogesterone acetate and dydrogesterone were given at the same dose for the same time interval , both drugs caused early secretory phase changes on rat endometrium. Conclusion: Dydrogesterone is the sterioisomer of natural progesterone,so it has less side effect than medroxyprogesterone. In conclusion dydrogesterone can be used instead of medroxyprogesterone acetate..

Özet

Amaç: Rat endometriumunda medroksiprogesteron asetat ve dydrogesteronun etkilerini karşılaştırmak. Yöntem: 28 adet Wistar cinsi dişi rat kullanıldı. Ratlar 3 gruba ayrıldı. A grubuna (10 rat) 20 gün 1mgr/gün oral medroksi progesteron asetat , B grubuna 20 gün 1mgr/gün oral dydrogesteron verildi. C grubuna ilaç verilmedi. 20 gün sonunda endometrium patolojik incelemeye tabii tutuldu. Bulgular: Her iki ilaç rat endometriumu üzerinde erken sekresyona sebep oldu. Sonuç: Dydrogesteron tabii progesteronun steroizomeridir. Medroksiprogesteron asetattan daha az yan etkiye sahiptir. Bu nedenle dydrogesteron, medroksiprogesteron asetat yerine kullanılabilinir.

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Cite This Article

KAYMAKÇI, M., ACAR, A., ÇAPAR, M., BALA, A., AKYÜREK, C. (2000). Analysis of medroxyprogesterone acetate and dydrogesterone effects on rat endometrium. Genel Tıp Dergisi, Cilt: 10 - Sayı: 3, 121–126. https://ajindex.com/articles/224885

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