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Journals / Genel Tıp Dergisi / 2019 / Cilt: 29 - Sayı: 2

Tiroid fonksiyonunun prematüre bebeklerde patent duktus arteriozus üzerine etkisi

Davut BOZKAYA
Sabriye YAMAN
Ufuk CAKIR
Mehmet BÜYÜKTİRYAKİ
Dursun TÜRKBAY
CÜNEYT TAYMAN
Pages
87–91
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our results showed that the level of fT4 was low in infants who were resistant to medical treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the relationship between PDA and congenital hypothyroidism.
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Key Findings & Data:Material and Methods: Zekai Tahir Burak Women's Health Education and Research Hospital Newborn Unit was performed between January 2015 and December 2017.
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Conclusion & Impact:Conclusion: Our results showed that the level of fT4 was low in infants who were resistant to medical treatment.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the relationship between PDA and congenital hypothyroidism. Material and Methods: Zekai Tahir Burak Women's Health Education and Research Hospital Newborn Unit was performed between January 2015 and December 2017. Infants with gestational age <30 weeks and birth weight <1500 g were included in the study. All infants was performed to Echocardiography on the 3rd day and on thyroid function tests were viewed on the 5th and 7th days. Results: A total of 178 prematurity infants were included in this retrospective descriptive study. There were 112 infants in Group 1 (non-PDA) and 68 infants in Group 2 (hemodynamically significant PDA). No statistically significant difference was found between group 1 and group 2 in terms of free thyroxine (sT4) levels. However, sT4 levels were significantly lower in infants who underwent surgical PDA ligation in group 2 patients (p = 0.05). Conclusion: Our results showed that the level of fT4 was low in infants who were resistant to medical treatment. Hypothyroidism should be kept in mind in infants with PDA who do not respond to medical therapy.

Özet

Amaç: Patent duktus arteriyozus (PDA) ile konjenital hipotiroidi arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Çalışmaya Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Yenidoğan Ünitesinde Ocak 2015- Aralık 2017 tarihleri arasında yatan, doğumda gestasyon haftası <30 hafta ve doğum ağırlığı <1500 gr olan, 3. gün ekokardiyografisi yapılan ve 5-7. gün tiroid fonksiyon testleri bakılan infantlar çalışmaya dâhil edildi. Bulgular: Bu retrospektif tanımlayıcı çalışmaya toplam 178 prematüre infant dâhil edildi. Grup 1 (PDA olmayan) ’de 112 infant, Grup 2 (hemodinamik anlamlı PDA’sı olan)’de ise 68 infant mevcuttu. Serbest Tiroksin (sT4) düzeyleri açısından grup 1 ile grup 2 arasında istatiksel bir fark saptanmadı. Ancak grup 2 hastalarda alt grup incelemesinde cerrahi PDA ligasyonu yapılan bebeklerde sT4 düzeyi istatistiksel olarak anlamlı düşük bulundu (p= 0.05). Sonuç: Çalışmamızda medikal tedaviye dirençli bebeklerde sT4 düzeyinin düşük olduğu gösterildi. Medikal tedaviye yanıtsız PDA'lı bebeklerde hipotiroidi akılda tutulmalıdır.

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Cite This Article

BOZKAYA, D., YAMAN, S., CAKIR, U., BÜYÜKTİRYAKİ, M., TÜRKBAY, D., TAYMAN, C. (2019). Tiroid fonksiyonunun prematüre bebeklerde patent duktus arteriozus üzerine etkisi. Genel Tıp Dergisi, Cilt: 29 - Sayı: 2, 87–91. https://ajindex.com/articles/224812

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References (10)

  1. Kreisner E, Neto EC, Gross JL. High prevalence of extrathyroid malformations in a cohort of Brazilian patients with permanent primary congenital hypothyroidism. Thyroid 2005;15:165-9. Nakagawa T. Delayed closure of ductus arteriosus in premature infants with transient hypothyroidism. Lancet 1993;341:839. livieri A, Stazi MA, Mastroiacovo P, et al. A population-based study on the frequency of additional congenital malformations in infants with congenital hypothyroidism: data from the Italian Registry for Congenital Hypothyroidism (1991-1998). J Clin Endocrinol Metab 2002;87:557-62.
  2. Prescott S, Keim-Malpass J. Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and reatment Options. Adv Neonatal Care 2017;17:10-8.
  3. Allegaert K, Anderson B, Simons S, van Overmeire B. Paracetamol to induce ductus arteriosus closure: is it valid? Arch Dis Child 2013;98:462-6.
  4. Coceani F, Baragatti B. Mechanisms for ductus arteriosus closure. Semin Perinatol 2012;36:92-7.
  5. Coceani F, Kelsey L, Seidlitz E, Korzekwa K. Inhibition of the contraction of the ductus arteriosus to oxygen by 1-aminobenzotriazole, a mechanism-based inactivator of cytochrome P450. Br J Pharmacol 1996;117:1586-92.
  6. Clyman RI, Seidner SR, Kajino H, et al. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol 2002;282:R199-206. Rose SR, Brown RS, Foley T, et al. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics 2006;117:2290-303.
  7. Musewe NN, Olley PM. Patent Ductus Arteriosus. In: Freedom RM, Benson LN, Smallhorn JF.Neonatal Heart Disease. Springer-Verlag, London, 1992; 593-609.
  8. Kajino H, Chen YQ, Seidner SR, et al. Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling. Am J Physiol Regul Integr Comp Physiol 2001;281:R291-301. Bhattacharya M, Asselin P, Hardy P, et al. Developmental changes in prostaglandin E(2) receptor subtypes in porcine ductus arteriosus. Possible contribution in altered responsiveness to prostaglandin E(2). Circulation 1999;100:1751-6.
  9. Bouayad A, Kajino H, Waleh N, et al. Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus. Am J Physiol Heart Circ Physiol 2001;280:H2342-9. Clyman RI, Tannenbaum J, Chen YQ, et al. Ductus arteriosus smooth muscle cell migration on collagen: dependence on laminin and its receptors. J Cell Sci 1994;107:1007-18.
  10. Farwell AP, Dubord-Tomasetti SA. Thyroid hormone regulates the ext