SavedAdd your journal

Journals / Fırat Tıp Dergisi / 2018 / Cilt: 23 - Sayı: 0

Relation between Obesity and the Gastrointestinal System

Obezite ve Gastrointestinal Sistem İlişkisi

ABDURRAHMAN ŞAHİN
MEHMET YALNIZ
Pages
22–29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review we discuss the effects of enteric hormones and intestinal microbiota on the pathophysiological mechanisms revealing obesity, including ingestive beha-vior, energy expenditure and metabolism.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The obesity epidemic is rapidly becoming one of the leading causes of mortality and morbidity worldwide.
📊
Key Findings & Data:Over the past 30 years, gastrointestinal hormones have been increasingly understood to have an important role as regulators of appetite and energy balance in obese individuals.
💡
Conclusion & Impact:In this review we discuss the effects of enteric hormones and intestinal microbiota on the pathophysiological mechanisms revealing obesity, including ingestive beha-vior, energy expenditure and metabolism.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The obesity epidemic is rapidly becoming one of the leading causes of mortality and morbidity worldwide. Over the past 30 years, gastrointestinal hormones have been increasingly understood to have an important role as regulators of appetite and energy balance in obese individuals. Intestinal microbiota also plays a significant role in the development of obesity, obesity-associated inflammation and metabolic syndrome. In this review we discuss the effects of enteric hormones and intestinal microbiota on the pathophysiological mechanisms revealing obesity, including ingestive beha-vior, energy expenditure and metabolism.

Özet

ÖZET Obezite epidemisi, hızla dünya çapında mortalite ve morbiditenin önde gelen nedenlerinden biri haline gelmektedir. Son 30 yılda, gastrointestinal hormonların, obez bireylerde iştah ve enerji dengesinin düzenleyicileri olarak önemli bir rol oynadığı giderek daha fazla anlaşılmıştır. İntestinal mikrobiyota da obezite, obezite ile ilişkili inflamasyon ve metabolik sendrom gelişiminde önemli bir rol oynar. Bu derlemede, enterik hormonların ve intestinal mikrobiyotanın, yeme davranışı, enerji tüketimi ve metabolizma gibi obeziteyi ortaya çıkaran patofizyolojik mekanizmalar üzerindeki etkileri tartışılmaktadır.

🔖

Cite This Article

ŞAHİN, A., YALNIZ, M. (2018). Relation between Obesity and the Gastrointestinal System. Fırat Tıp Dergisi, Cilt: 23 - Sayı: 0, 22–29. https://ajindex.com/articles/223869

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. WHO. WHO: obesity and overweight. 2017. http://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 03.05.2018.
  2. Troke RC, Tan TM, Bloom SR. The future role of gut hormones in the treatment of obesity. Ther Adv Chronic Dis 2014; 5: 4-14. Kopelman P. Health risks associated with overweight and obesity. Obes Rev 2007; 8: 13-7.
  3. Munzberg H, Qualls-Creekmore E, Yu S et al. Hedonics act in unison with the homeostatic system to unconsciously control body weight. Front Nutr 2016; 3: 6. Heisler LK, Lam DD. An appetite for life: brain regulation of hunger and satiety. Curr Opin Pharmacol 2017; 37: 100-6.
  4. Merlino DJ, Blomain ES, Aing AS, et al. Gut-brain endocrine axes in weight regulation and obesity pharmacotherapy. J Clin Med 2014; 3: 763-94. Sharkey KA. Targeting the gut to treat obesity and its metabolic consequences: view from the Chair. Int J Obes Suppl 2016; 6: 3-5.
  5. Bauer PV, Hamr SC, Duca FA. Regulation of energy balance by a gut-brain axis and involvement of the gut microbiota. Cell Mol Life Sci 2016; 73: 737-55.
  6. Westfall S, Lomis N, Kahouli I, et al. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci 2017; 74: 3769-87.
  7. Clemmensen C, Muller TD, Woods SC, et al. Gut-brain cross-talk in metabolic control. Cell 2017; 168: 758-74.
  8. Gribble FM, Reimann F. Signalling in the gut endocrine axis. Physiol Behav 2017; 176: 183-8. Buhmann H, le Roux CW, Bueter M. The gut-brain axis in obesity. Best Pract Res Clin Gastroenterol 2014; 28: 559-71.
  9. Lean ME, Malkova D. Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence? Int J Obes 2016; 40: 622-32.
  10. Huda MS, Wilding JP, Pinkney JH. Gut peptides and the regulation of appetite. Obes Rev 2006; 7: 163-82.
  11. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
  12. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623-30.
  13. Hussain SS, Bloom SR. The regulation of food intake by the gut-brain axis: implications for obesity. Int J Obes 2013; 37: 625-33.
  14. Adamska E, Ostrowska L, Gorska M, et al. The role of gastrointestinal hormones in the pathogenesis of obesity and type 2 diabetes. Prz Gastroenterol 2014; 9: 69-76.
  15. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-57. Field BC. Neuroendocrinology of obesity.