Journals / Fırat Tıp Dergisi / 2006 / Cilt: 11 - Sayı: 3

The safety and quality of low flow anaesthesia with isoflurane, sevoflurane and desflurane

İzofluran, desfluran ve sevofluran ile uygulanan düşük akımlı anestezinin, anestezi kalitesi ve güvenilirliğinin karşılaştırılması

Pages
170–174
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Three were no differences between the groups at lowering flows, however patients at desflurane group awaked , recovery earlier than other groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives:Low flow anaesthesia is a method for reusing the expiration air.
📊
Key Findings & Data:Materials and Methods: Ethical commity approval, ASA I-II group, 20-50 years old, 60 patients included into the study.
💡
Conclusion & Impact:Three were no differences between the groups at lowering flows, however patients at desflurane group awaked , recovery earlier than other groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anestezi · İzofluran · Anesthesia

Abstract

Objectives:Low flow anaesthesia is a method for reusing the expiration air. In this study we compare the anaesthesia quality and security at isoflurane, sevoflurane, desflurane in low flow anaesthesia. Materials and Methods: Ethical commity approval, ASA I-II group, 20-50 years old, 60 patients included into the study. The patients were randommily divided into 3 groups. 50 % O2 in 50 % air used for maintainance of anaesthesia, patients received 1,5 % isoflurane , 2 % sevoflurane, 5 % desflurane. Urea, creatinin, SGOT, SGPT, GGT, CK-MB, troponin blood samples obtained also both urine urea, creatinin measured. We examine the quality of awakening, recovery.Kruskal-Wallis, chi-square, ANOVA tests are used for the stastistical analysis. Results:The inspired O2 values decreased statistically significant at 7th period. The expired O2 values at sevoflurane group were statistically significant lower than control group at 8th,9th period.The inspired CO2 values at all three groups decreased statistically significant compared to control group.The expired CO2 values decreased CO2 values decreased statistically meaning fally at 6,8 and 9th periods at isoflurane group, when compared with 1th period, at 7,8 and 9 th periods at sevoflurane group , desflurane group.PaCO2 values at 1 th period were increased statistically significant at 6,8 and 9th periods in isoflurane and at 7,8 and 9th periods in both sevoflurane, desflurane groups. Conclusion: The low flow anaesthesia by all agents were secure. Three were no differences between the groups at lowering flows, however patients at desflurane group awaked , recovery earlier than other groups.

Özet

Amaç: Düşük akımlı anestezi ekspirasyon havasının yeniden kullanımını artırmayı amaçlayan bir yöntemdir. Bu çalışmada düşük akımlı anestezide, izofluran, sevofluran, desfluran güvenlik ve anestezi kalitesi açısından karşılaştırıldı. Gereç ve Yöntem: Etik kurul ve hasta onayıyla, 20-50 yaşlarında, ASA I-II, 60 hasta çalışmaya alındı. Hastalar randomize olarak 3 gruba (n=20) ayrıldılar. Anestezi idamesinde %50 O2, %50 hava içinde; izofluran grubuna (Grup İ) %1.5 izofluran, sevofluran grubuna (Grup S) %2 sevofluran, desfluran grubuna (Grup D) %5 desfluran, uygulandı. Anestezi süresince hemodinamik, solunumsal parametreler izlendi, kan gazı örnekleri alındı. Kanda üre, kreatinin, serum glutamik okzaloasetik transferaz, serum glutamik pürivik transferaz, laktat dehidrogenaz, gama glutamil transpeptitaz, kreatin kinaz myokard bandı, troponin, idrarda üre ve kreatinin ölçüldü. Uyanma, derlenme kalitesi değerlendirildi.Veriler, Kruskal- Wallis, chisquare ve ANOVA testleri ile değerlendirildi. p<0,05 anlamlı kabul edildi. Bulgular: İnspire edilen O2 değerleri Grup-S’de 1. döneme göre 7,8,9. dönemlerde istatistiksel anlamlı azaldı (p<0,05). 7. dönemde Grup-D’nin değeri, izofluran grubuna göre istatistik anlamlı düşüktü (p<0,05).Ekspire edilen O2 değerleri Grup-S’de 8 , 9. dönemlerde 1.döneme göre istatistiksel anlamlı azaldı (p<0,05).İnspire edilen CO2 değerleri üç grupta, 1.döneme göre 6, 7, 8, 9. dönemlerde istatistiksel anlamlı arttı (p<0,05).Ekspire edilen CO2 değerleri, 1. döneme göre Grup-İ’de 6, 8, 9. Grup-S’de, Grup-D’de, 7, 8, 9. zamanlarda istatistiksel anlamlı arttı (p<0,05). PaCO2, 1.döneme göre Grup-İ’de 8, 9. Grup-S’de 7, 8, 9, Grup-D’de ise 6, 7, 8 , 9. dönemlerinde istatistiksel anlamlı arttı (p<0,05). Sonuç: Her üç ajanla uygulanan düşük akımlı anestezinin, güvenli olduğu, akımın azaltılması açısından birbirlerine üstünlüklerinin olmadığı, Grup- D’deki hastaların erken uyandığı, derlendiği ortaya çıkmıştır.

🔖

Cite This Article

YILDIRIM, A., GÖKSU, H., TOPRAK, Ç. G., KILIÇ, R., YAŞAR, M. A. (2006). The safety and quality of low flow anaesthesia with isoflurane, sevoflurane and desflurane. Fırat Tıp Dergisi, Cilt: 11 - Sayı: 3, 170–174. https://ajindex.com/articles/223787

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Baum JA. Low-flow anaesthesia: The sensible and judicious use of inhalation anaesthetic M105. Acta Anaesthesiol Scand 1997; 41: 264-267
  2. Coetzee JF, Stewart LJ. Fresh gas flow is not the only determinant of volatile agent consumption: a multi- centre study of low-flow anaesthesia. Br J Anaesth 2002; 88: 46-55 3. Baum JA. Low Flow Anaesthesia. The Theory and practice of low flow, minimal flow and closed system anaesthesia. 2nd English ed. London: Reed Educational and Professional Publishing Ltd, 2001
  3. Baum JA. Low-flow anaesthesia. Eur J Anaesthesiol 1996; 13: 432-435
  4. Cotter SM, Petros AJ, Dore CJ, Barber ND, White DC. Low - flow anaesthesia, practice cost implications and acceptability. Anaesthesia 1991; 46: 1009 – 1012 6. Baum J, Zuchner K, Holscher U, Sievert B, Stanke HG, Gruchmann T, Rathgeber J. Climatization of anesthetic gases using different breathing hose systems. Anaesthesist 2000; 49: 4 Wissing H, Kuhn I, Reitbrock S, Fuhr U. Pharmacokinetics of inhaled anaesthesics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane. Br J Anaesth 2000; 84: 443-449
  5. Brown B. Sevoflurane: Introduction and overview. Anesth Analg 1995; 81: 51-53
  6. Igarashi M, Watanabe H, Iwsaki H, Namiki A. Clinical evaluation of low-flow sevoflurane anaesthesia for paediatric patients. Acta Anaesthesiol Scand 1999; 43: 19-23
  7. Düşük Akımlı Anestezi Sempozyumu Konuşma Metinleri. Anestezi Dergisi 2002; 10: 119-156
  8. Pedersen FM, Nielsen J, Ibsen M, Guldager H. Low-flow isoflurane-nitrous oxide anaesthesia offers substantial economic advantages over high- and medium-flow isoflurane-nitrous oxide anaesthesia. Acta Anaesthesiol Scand 1993; 37: 509-512
  9. Baum J, Sievert B, Stanke HG, Brauer K, Sachs G. Nitrous oxide free low-flow anesthesia. Anaesthesiol Reanim 2000; 25: 60-67
  10. Bito H, Ikeda K. Long-duration, low-flow sevoflurane anesthesia using two carbon dioxide absorbents. Quantification of degradation products in the circuit. Anesthesiology 1994; 81: 340-345 13. Bonome C, Belda J, Alvarez R, Soro M, Fernandez G, Cortes A. Low-flow anesthesia and reduced animal size increase carbowyhemoglobin levels in swine during desflurane and isoflurane breakdown in dried sodalaym. Anesth Analg 1999; 89: 909-919
  11. Higuchi H, Hiroki W, Yumi U, Kohichiro G, Masuyuki K, Tetsuo S. Effects of probenecid on renal function in surgical patients anesthetized with low-flow sevoflurane. Anesthesiology 2001; 94: 21-31
  12. Ebert TJ, Frink EJ, Kharasc