Journals / Fırat Tıp Dergisi / 2009 / Cilt: 14 - Sayı: 3

Effects of electroconvulsive therapy on sympathetic skin responses in patients with major depression

Major depresyonlu hastalarda elektrokonvulsiv terapinin sempatik deri yanıtı üzerine etkileri

Pages
167–170
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More studies are needed to evaluate the effects of depression treatment with ECT on SSR.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Depressed patients frequently complain about vegetative symptoms.
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Key Findings & Data:Materials and Methods: In our study we examined 40 patients diagnosed with major depression who would take ECT during a course of treatment and 30 age-matched healthy subjects.
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Conclusion & Impact:More studies are needed to evaluate the effects of depression treatment with ECT on SSR.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Depressed patients frequently complain about vegetative symptoms. The relation between depression and disturbances of autonomic regulation has been recognised for a long time. The aim of this study was to investigate whether sympathetic skin responses (SSRs) were affected by electroconvulsive therapy (ECT) in patients with major depression. Materials and Methods: In our study we examined 40 patients diagnosed with major depression who would take ECT during a course of treatment and 30 age-matched healthy subjects. Sympathetic skin responses were assesed on the same day before and after the ECT. Pre-ECT, post-ECT, and control groups' measurements of SSR were compared by non-parametric tests. Results: The mean post-ECT latency of SSR (1.25±0.11 ms) was statistically significantly different (p <0.05) compared with pre-ECT latency of SSR (1.26± 0.11 ms) in patients with major depression. This result demonstrates a relation between SSR and ECT in patients with major depression. However there was no significant difference in SSR latency between patients (pre-ECT and post-ECT) and controls (1.22±0.08 ms). There was no statistically difference also in SSR amplitude among three groups. Conclusion: Data reported in this article support that activation of sympathetic system by ECT treatment does not have a major efficacy in patients with major depression. More studies are needed to evaluate the effects of depression treatment with ECT on SSR.

Özet

Amaç: Depresif hastalar sıklıkla vejetatif semptomlardan yakınmaktadırlar. Depresyon ve otonom regülasyon bozuklukları arasındaki ilişki uzun zamandan beri bilinmektedir. Bu çalışmanın amacı major depresyonu olan hastalarda elektrokonvulziv terapi ile (EKT) sempatik deri yanıtlarının (SDY) etkilenip etkilenmediğini değerlendirmektir. Gereç ve Yöntemler: Çalışmamızda tedavi sürecinde EKT yapılacak major depresyonu olan 40 hasta ve 30 sağlıklı kişi incelendi. Sempatik deri yanıtları EKT nin uygulandığı aynı gün içerisinde EKT uygulanmasından önce ve sonra değerlendirildi. Elektrokonvulziv terapi öncesi, EKT sonrası ve kontrol grubuna ait SDY ölçümleri nonparametrik testlerle karşılaştırıldı. Bulgular: Major depresyonu olan hastalarda EKT sonrası SDY latans ortalaması (1.25±0.11 ms) EKT öncesi SDY latans ortalamasından (1.26± 0.11 ms) istatistiksel olarak anlamlı ölçüde farklı bulundu (p <0.05). Bu sonuç, major depresyonu olan hastalarda EKT ve SDY arasında bir ilişki olduğunu göstermektedir. Bununla birlikte SDY latans değerlerinde hastalarla (EKT öncesi ve EKT sonrası) kontrol grubu (1.22±0.08 ms) arasında anlamlı farklılık yoktu. Sempatik deri yanıtları amplitüd değerlerinde de üç grup arasında anlamlı farklılık yoktu. Sonuç: Bu makalede bildirilen veriler major depresyonu olan hastalarda EKT tedavisinin neden olduğu sempatik sistem aktivasyonu üzerine major bir etkisi olmadığını desteklemektedir. Elektrokonvulziv terapi ile depresyon tedavisinin SDY üzerine etkilerini değerlendirmek için daha başka çalışmalara gereksinim vardır.

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Cite This Article

DEMİR, C. F., BİLİCİ, R., ÖZDEMİR, H. H., BERİLGEN, S. (2009). Effects of electroconvulsive therapy on sympathetic skin responses in patients with major depression. Fırat Tıp Dergisi, Cilt: 14 - Sayı: 3, 167–170. https://ajindex.com/articles/223736

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