SavedAdd your journal

Journals / Fırat Tıp Dergisi / 2015 / Cilt: 20 - Sayı: 3

Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients

Editöre Mektup: Ortalama Trombosit Hacmi Yeni Tanı Konulmuş Hipertansif Hastalarda Arteriyel Sertlik İçin Yararlı Bir Belirteç Olmayabilir

Cengiz BEYAN
Esin BEYAN
Pages
182–183
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, MPV may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients Nowadays, turbidimetric platelet aggregation is the gold standard test for evaluation of platelet function, and platelet indices including mean platelet volume (MPV) were not correlated with the results of turbidimetric platelet aggregation.
📊
Key Findings & Data:MPV progressively increases with time in anticoagulated samples.
💡
Conclusion & Impact:As a result, MPV may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients Nowadays, turbidimetric platelet aggregation is the gold standard test for evaluation of platelet function, and platelet indices including mean platelet volume (MPV) were not correlated with the results of turbidimetric platelet aggregation. Also, measurement of MPV cannot be performed completely because of standardization problems. MPV progressively increases with time in anticoagulated samples. Optimal measurement time with citrate should be 60 minutes after venipuncture in the determination of MPV. Another important problem regarding MPV measurement is that different technologies reveal different results up to 40%. As a result, MPV may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients.

Özet

ÖZET Günümüzde, türbidimetrik trombosit agregasyonu trombosit fonksiyonlarının değerlendirilmesinde altın standart testtir ve ortalama trombosit hacmi (OTH) dahil olmak üzere trombosit parametrelerinin türbidimetrik trombosit agregasyonu sonuçları ile korelasyonu yoktur. Keza, OTH ölçümü standardizasyon problemleri nedeni ile tam olarak uygulanamaz. OTH antikoagüle edilmiş numunelerde zamanla giderek artış gösterir. OTH tayininde sitrat ile en uygun ölçüm zamanı kanın alınmasından 60 dakika sonradır. OTH ölçümüne dair başka bir önemli problem farklı teknolojilerin %40’a kadar varan farklı sonuçlar verebilmesidir. Sonuç olarak, OTH yeni tanı konulmuş hipertansif hastalarda arteriyel sertlik için yararlı bir belirteç olmayabilir.

🔖

Cite This Article

BEYAN, C., BEYAN, E. (2015). Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients. Fırat Tıp Dergisi, Cilt: 20 - Sayı: 3, 182–183. https://ajindex.com/articles/223578

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (6)

  1. Karakan Ş, Sezer S. Yeni tanı hipertansif hastalarda ortalama trombosit hacmi ve arteriyel sertlik ilişkisi. Fırat Tıp Dergisi 2014; 19: 189-92.
  2. Ho CH, Chan IH. The influence of time of storage, temperature of storage, platelet number in platelet-rich plasma, packed cell, mean platelet volume, hemoglobin concentration, age, and sex on platelet aggregation test. Ann Hematol 1995; 71: 129-33.
  3. Beyan C, Kaptan K, Ifran A. Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggregation responses in healthy volunteers. J Thromb Thrombolysis 2006; 22: 161-4.
  4. De Luca G, Verdoia M, Cassetti E et al. Mean platelet volume is not associated with platelet reactivity and the extent of coronary artery disease in diabetic patients. Blood Coagul Fibrinolysis 2013; 24: 619-24. Harrison P. “Platelet function testing”. UpToDate. http://www.uptodate.com/contents/platelet-function-testing/ 23.01.2014. 6. 7. 8. 9. 10. George TI. “Automated hematology instrumentation”. UpToDate. http://www.uptodate.com/contents/automated- hematology-instrumentation/ 24.03.2014. Kuter DJ. “Megakaryocyte biology and the production of platelets”. UpToDate. http://www.uptodate.com/contents/megakaryocyte-biology-and- the-production-of-platelets/ 05.03.2014
  5. Lance MD, Sloep M, Henskens YM et al. Mean platelet volume as a diagnostic marker for cardiovascular disease: drawbacks of preanalytical conditions and measuring techniques. Clin Appl Thromb Hemost 2012; 18: 561-8.
  6. Lance MD, Henskens YM, Marcus MA. Mean platelet volume analysis needs more standardization. Platelets 2011; 22: 241. Lance MD, van Oerle R, Henskens YM, et al. Do we need time adjusted mean platelet volume measurements? Lab Hematol 2010; 16: 28-31.