Journals / Erciyes Medical Journal / 2020 / Cilt: 42 - Sayı: 3

Increased High Sensitive C-reactive Protein is Associated with Major Adverse Cardiovascular Events after STEMI

Pages
276–280
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The hsCRP values in patients with STEMI who were treated with the pPCI are related to systolic function in the early phase of STEMI, as well as MACE during the first six months of follow-up.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aims to investigate whether the high sensitive C-reactive protein (hsCRP) is associated with an ejection fraction of left ventricle (EFLV) in the early phase of ST-elevation myocardial infarction (STEMI), treated with the primary percutaneous intervention (pPCI), and to establish whether there exists a relationship between its values and the presence of major adverse cardiovascular events (MACE) within six months of pPCI.
📊
Key Findings & Data:Materials and Methods: In this prospective study, 357 patients who were diagnosed with STEMI and who underwent pPCI within 24 hours of pain onset were included.
💡
Conclusion & Impact:Conclusion: The hsCRP values in patients with STEMI who were treated with the pPCI are related to systolic function in the early phase of STEMI, as well as MACE during the first six months of follow-up.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: This study aims to investigate whether the high sensitive C-reactive protein (hsCRP) is associated with an ejection fraction of left ventricle (EFLV) in the early phase of ST-elevation myocardial infarction (STEMI), treated with the primary percutaneous intervention (pPCI), and to establish whether there exists a relationship between its values and the presence of major adverse cardiovascular events (MACE) within six months of pPCI. Materials and Methods: In this prospective study, 357 patients who were diagnosed with STEMI and who underwent pPCI within 24 hours of pain onset were included. The following were monitored and recorded: 1) hsCRP values, which were measured between 24 and 48 hours of pPCI, 2) EFLV values, which were measured five days after the pPCI, and 3) MACE, which was established within six months of pPCI. Results: The EFLV values measured five days after the pPCI were significantly lower with increasing hsCRP values (rho=- 0.384, p<0.0001). There was a significant difference in hsCRP values between patients who had MACE and those without it (38.35 [98.10] vs. 12.97 [23.80], p=0.0001). In addition, hsCRP values were significantly increased in patients who died during the first six months after the pPCI compared with patients who survived (115.00 [202.80] vs. 15.84 [31.5], p=0.001). Conclusion: The hsCRP values in patients with STEMI who were treated with the pPCI are related to systolic function in the early phase of STEMI, as well as MACE during the first six months of follow-up.

🔖

Cite This Article

BEGİC, E., OBRADOVIC, S., JANKOVİC, S., ROMANOVİC, R., DJENİC, N., DZUDOVİC, B., JOVİC, Z., MALOVİC, D., SUBOTA, V., STAVRİC, M., LJUCA, F., KUSLJUGİC, Z. (2020). Increased High Sensitive C-reactive Protein is Associated with Major Adverse Cardiovascular Events after STEMI. Erciyes Medical Journal, Cilt: 42 - Sayı: 3, 276–280. https://ajindex.com/articles/223446

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Bahall M, Seemungal T, Legall G. Risk factors for first-time acute myocardial infarction patients in Trinidad. BMC Public Health 2018; 18(1): 161
  2. Kiani F, Hesabi N, Arbabisarjou A. Assessment of Risk Factors in Patients With Myocardial Infarction. Glob J Health Sci 2015; 8(1): 255–62
  3. Kamath DY, Xavier D, Sigamani A, Pais P. High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: An Indian perspective. Indian J Med Res 2015; 142(3): 261–8
  4. Roberts WL; CDC; AHA. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: laboratory tests available to assess inflammation--performance and standardization: a background paper. Circulation 2004; 110(25): e572–6
  5. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol 2018; 9: 754
  6. Tanaka T, Kishimoto T. The biology and medical implications of interleukin- 6. Cancer Immunol Res 2014; 2(4): 288–94
  7. Ritschel VN, Seljeflot I, Arnesen H, Halvorsen S, Weiss T, Eritsland J, et al. IL-6 signalling in patients with acute ST-elevation myocardial infarction. Results Immunol 2013; 4: 8–13
  8. Reindl M, Reinstadler SJ, Feistritzer HJ, Theurl M, Basic D, Eigler C, et al. Relation of Low-Density Lipoprotein Cholesterol With Microvascular Injury and Clinical Outcome in Revascularized ST-Elevation Myocardial Infarction. J Am Heart Assoc 2017; 6(10): e006957
  9. Swiatkiewicz I, Kozinski M, Magielski P, Fabiszak T, Sukiennik A, Navarese EP, et al. Value of C-reactive protein in predicting left ventricular remodelling in patients with a first ST-segment elevation myocardial infarction. Mediators Inflamm 2012; 2012: 250867
  10. Ribeiro DR, Ramos AM, Vieira PL, Menti E, Bordin OL Jr, Souza PA, et al. High-sensitivity C-reactive protein as a predictor of cardiovascular events after ST-elevation myocardial infarction. Arq Bras Cardiol 2014; 103(1): 69-75
  11. Schiele F, Meneveau N, Seronde MF, Chopard R, Descotes-Genon V, Dutheil J, et al; Reseau de Cardiologie de Franche Comte. C-reactive protein improves risk prediction in patients with acute coronary syndromes. Eur Heart J 2010; 31(3): 290–7
  12. Arruda-Olson AM, Reeder GS, Bell MR, Weston SA, Roger VL. Neutrophilia predicts death and heart failure after myocardial infarction: a community-based study. Circ Cardiovasc Qual Outcomes 2009; 2(6): 656–62
  13. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial in