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Journals / Ege Tıp Dergisi / 2009 / Cilt: 48 - Sayı: 3

Pediatrik lupus nefritinin retrospektif izlem sonuçları, tek merkez çalışması

Retrospective analysis of the outcome of pediatric lupus nephritis, single center study

Betül SÖZERİ
S. MİR
F. MUTLUBAS
S. ŞEN
Pages
181–187
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Result: Finally, the prognosis of children with LN depends primarily on the severity of histopathological lesions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: We aim to analyse in this study was outcome results and therapy modalities in patients with lupus nephritis.
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Key Findings & Data:Materials and Methods: We performed a retrospective cohort study of our 37 lupus patients, diagnosed and treated between1986-2006.
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Conclusion & Impact:Result: Finally, the prognosis of children with LN depends primarily on the severity of histopathological lesions.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: We aim to analyse in this study was outcome results and therapy modalities in patients with lupus nephritis. Materials and Methods: We performed a retrospective cohort study of our 37 lupus patients, diagnosed and treated between1986-2006. Conclusions: The mean age at onset of disease was 13 ± 2.2 years. Renal involvement was present in 26 (70.2%) of the patients. At the time of the initial biopsy, proteinuria was observed in 15 (57.7%) patients, and it was within nephrotic range in 4 (15.3%) patients. 11 (42.3%) patients had hematuria, 7 (26.9%) had hypertension, and 6 (23%) had impaired renal function. The most frequent histopathological finding was class II (42.3%), followed by class IV (30.7%), class III (15.3%) and class I (11.7%) lupus nephritis (LN). All patients with class IV lupus nephritis had a significant tendency for developing hypertension (p=0.006) and nephrotic range proteinuria (p=0.004). 57% of patients with lupus nephritis had remission, 30% of them still had active disease. Result: Finally, the prognosis of children with LN depends primarily on the severity of histopathological lesions.

Özet

Amaç: Bu çalışmanın amacı lupus nefritli hastaların tedavi yönetemlerini ve izlem sonuçlarını analiz etmektir. Yöntem ve Gereç: Kliniğimizde 1986-2006 yılları arasında tanı almış ve tedavi edilen 37 lupus hastasına retrospektif çalışma yapıldı. Bulgular: Ortalama tanı yaşı 13 ± 2,2 yıldı. Hastaların 26 (% 70,2)' sında böbrek tutulumu mevcuttu. İlk biyopsi anında proteinüri saptanan 15 (% 57.7) hastadan 4'ünde (%15.3) nefrotik düzeyde proteinüri vardı. 11(% 42.3) hastada hematüri, 7(% 26.9) hastada hipertansiyon ve 6 (23%) hastada renal fonksiyon bozukluğu saptandı. Lupus nefritinde histopatolojik bulgulardan evre II (% 42.3) en sık bulunurken, sırasıyla evre IV (% 30.7), evre III (15.3%) ve evre I (11.7%) saptandı. Tüm evre IV lupus nefritli hastalarda hipertansiyon ve nefrotik proteinuri anlamlı olarak yüksek saptandı. İzlem sonunda lupus nefriti olan hastaların %57'sinde remisyon varken %30 hasta aktif hastalık bulgularına sahipti. Sonuç: Sonuç olarak LN çocukların prognozu, primer olarak histopatolojik lezyonun şiddetine bağlıdır.

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Cite This Article

SÖZERİ, B., MİR, S., MUTLUBAS, F., ŞEN, S. (2009). Pediatrik lupus nefritinin retrospektif izlem sonuçları, tek merkez çalışması. Ege Tıp Dergisi, Cilt: 48 - Sayı: 3, 181–187. https://ajindex.com/articles/223310

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References (1)

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