AI Summary & Key Takeaways
AI InsightIn this study, histopathology and differential diagnosis of hepatoid adenocarcinoma was presented and discussed with reference to the literature.
📌 3 Key Takeaways
Abstract
Hepatoid adenocarcinoma is a rare primary gastric carcinoma, which shows glandular and hepatocellular differentiation. Cells showing hepatoid differentiation are usually stained positively with AFP. Three cases of hepatoid adenocarcinoma among 90 gastrectomy materials were analyzed retrospectively. Three cases had extensive vascular and serosal involvement and lymph node metastasis. Immunoreactivity for AFP was present in 2 cases, for chromogranin in 1 case and for ATT in all 3 cases. In this study, histopathology and differential diagnosis of hepatoid adenocarcinoma was presented and discussed with reference to the literature.
Özet
Hepatoid adenokarsinom, glandüler ve hepatosellüler diferansiyasyonu birlikte bulunduran ender görülen primer mide karsinomudur. Hepatoid diferansiyasyon gösteren hücreler immunohistokimyasal olarak genellikle alfa-fetoprotein (AFP) pozitif boyanırlar. Bu çalışmada son 7 yıl içinde mide karsinomu tanısı alan 90 gastrektomi materyalinin preparatları, retrospektif olarak tekrar incelenmiş bunlardan 3 hepatoid adenokarsinom olgusu çalışmaya alınmıştır. Üç olguda da yaygın damar tutulumu, seroza tutulumu ve lenf düğümü metastazı saptanmıştır. İmmunohistokimyasal olarak AFP'in 2 olguda, kromograninin 1 olguda, alfa-1-antitripsinin (AAT) ise 3 olguda da pozitif olduğu gözlenmiştir.