Journals / Ege Tıp Dergisi / 2001 / Cilt: 40 - Sayı: 3

Serum thyroid hormones, thyreostimulan hormone and thyroglobulin levels in cord blood and maternal circulation at the time of delivery

Doğumda anne ve bebeklerin serum tiroid hormonları, tiroidi stimule eden hormon ve tiroglobulin değerleri

Pages
159–163
DOI
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⚡ TL;DR(Too Long; Didn't Read)

We have suggested that the increased Tg levels in cord blood of newborns may be related with intrauterin fetal maturation.

📌 3 Key Takeaways

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Objective & Hypothesis:For evaluating of the thyroid gland functions in both maternal serum of the 52 healthy mothers who are 19 to 40 aged years old, and in the cord blood of their newborns, the levels of free T<sub>3</sub>, free T<sub>4</sub>, thyreostimulan hormone (TSH) and thyroglobulin were measured by using radioimmunoassay (RIA) and immunoradioassay (IHMA) technics.
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Key Findings & Data:The serum free T<sub>4</sub>, thyreostimulan hormone and thyroglobulin concentrations in the cord blood were higher than that in the serum of mothers (p<0.001).
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Conclusion & Impact:We have suggested that the increased Tg levels in cord blood of newborns may be related with intrauterin fetal maturation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Süt çocuğu · yenidoğan · Fetal kan

Abstract

For evaluating of the thyroid gland functions in both maternal serum of the 52 healthy mothers who are 19 to 40 aged years old, and in the cord blood of their newborns, the levels of free T<sub>3</sub>, free T<sub>4</sub>, thyreostimulan hormone (TSH) and thyroglobulin were measured by using radioimmunoassay (RIA) and immunoradioassay (IHMA) technics. Various comparisons were performed regarding to smoking habits and gestational age of the mothers, birth weights and Apgar indexes of the newborns. Independent Student's test for statistical analisis and Pearson correlation calculations for comparisons were employed. The serum free T<sub>4</sub>, thyreostimulan hormone and thyroglobulin concentrations in the cord blood were higher than that in the serum of mothers (p<0.001). Negative correlations were found between the cord serum thyroglobulin levels and the gestational age of mothers (r=-0.30) and birth weight of the newborns (r=-0,27). But sex of the newborns and smoking habit of the mothers were not making any significant changes on the other parameters measured. We have suggested that the increased Tg levels in cord blood of newborns may be related with intrauterin fetal maturation.

Özet

19-40 yaşları arasında 52 sağlıklı anne ve bu annelere ait sağlıklı bebeklerin kordon kanlarından tiroid fonksiyonlarını değerlendirmek üzere serbest T 3 (sT 3 ), serbest T 4 (sT 4 ), tiroidi stimüle ede hormon (TSH) ve tiroglobulin (Tg) düzeyleri radyoimmunoassay (RİA) ve immunoradyometrik assay (IRMA) yöntemleri kullanılarak ölçüldü. Annelerin sigara kullanma alışkanlıkları, gebelik yaşları, bebeklerin doğum ağırlıkları, cinsiyeti ve Apgar indeksleri dikkate alınarak çeşitli karşılaştırmalar yapıldı. İstatistiksel analizlerde independent student t testi, korelasyon hesaplarında Pearson korelasyon analizleri kullanıldı. Bebeklerin kordon kanı sT 4 , TSH ve tiroglobulin düzeylerinin annelerinkinden fazla olduğu (p<0,001) saptandı. Bebeklere ait kordon kanı tiroglobulin düzeyleri ile annelerin gebelik yaşları (r=-0,30) ve bebeklerin doğum ağırlıkları (r=-0,27) arasında negatif korelasyonlar bulundu. Bebeklerin cinsiyeti ve annelerin sigara alışkanlıkları gibi özellikler, ölçümü yapılan diğer parametrelerde anlamlı bir değişiklik oluşturmuyordu. Yeni doğanların kordon kanında saptadığımız Tg düzeylerindeki yüksekliğin fetusun intrauterin matürasyonu ile ilgili olabileceğini düşündük.

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Cite This Article

YILMAZ, H., ÖZKILIÇ, H., GÜNER, İ., ERGENOĞLU, A. M. (2001). Serum thyroid hormones, thyreostimulan hormone and thyroglobulin levels in cord blood and maternal circulation at the time of delivery. Ege Tıp Dergisi, Cilt: 40 - Sayı: 3, 159–163. https://ajindex.com/articles/223096

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