Journals / Ege Tıp Dergisi / 2008 / Cilt: 47 - Sayı: 1

Serum lipid levels in 5-15 years old children and affecting parameters

5-15 yaş çocuklarda serum lipid düzeyi ve etkileyen faktörler

Pages
35–45
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Hence, life style and eating habit changes in early ages may prevent development of early cardiovascular and cerebrovascular diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim : Though cardiovascular diseases are more often symptomatic in elderly than in childhood, it is well known that atherosclerosis starts in childhood age group.
📊
Key Findings & Data:Methods: This prospective, sectional and case controlled study included 1040 children, We analyzed plasma cholesterol, triglyceride (TG), VLDL, LDL and HDL- cholesterol levels.
💡
Conclusion & Impact:Hence, life style and eating habit changes in early ages may prevent development of early cardiovascular and cerebrovascular diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim : Though cardiovascular diseases are more often symptomatic in elderly than in childhood, it is well known that atherosclerosis starts in childhood age group. To investigate the prevalence of hyperlipidemia and affecting factors in school-age Turkish children. Methods: This prospective, sectional and case controlled study included 1040 children, We analyzed plasma cholesterol, triglyceride (TG), VLDL, LDL and HDL- cholesterol levels. Plasma homosistein level was analyzed when plasma lipids were above the cut-off limits. The children were divided into three age groups: 5-8.9, 9-11.9, and 12-15 years. Results: Mean plasma cholesterol, VLDL, LDL, HDL and TG levels of the study group were 142.4±26.8, 14.1±7.5, 82.8±25.6, 45.3±9.5 and 70.8±37.7mg/dL, respectively. TC, HDL and LDL-C levels showed insignificant difference between age groups, whereas TG and VLDL-C levels were significantly lower in 5 and 8.9 age group compared to the other groups (p<0.05). Body mass index showed positive correlation with plasma cholesterol, VLDL and TG levels(p<0.05,r: 0.014,r:0.117 and r:0.121, respectively). There was a positive correlation between homocysteine and cholesterol level (p<0.05,r:=0.642). The mean plasma homocysteine level of the positive family history group for the early cardio and cerebrovascular diseases was higher than the negative family history (EFH)(p<0.05). Multivariant logistic regression analysis was used evaluate cofactors affecting EFH, none of the factors were found to have a correlation with early disease development (p=0.159). There was a significant relation between TC, TG, VLDL-C serum levels, BMI and the type of consumed fat (p<0.05). Conclusion: Lipid profile may not be useful for investigation of the early risk factors for cardiovascular disease in childhood group, expect in obese children. Obesity and unsaturated oil consumption are preventable factors that affect blood lipid levels. Hence, life style and eating habit changes in early ages may prevent development of early cardiovascular and cerebrovascular diseases.

Özet

Amaç : Kardiyovasküler hastalıklar sıklıkla eriskin dönemde bulgu vermekle birlikte aterosklerozun çocukluk döneminde basladığı bilinmektedir. Okul çağı Türk çocuklarında hiperlipidemi sıklığını ve bunu etkileyen faktörleri arastırmaktır. Gereç ve Yöntem : Bu çalısma, prospektif, kesitsel ve vaka kontrollü bir çalısmadır ve 1040 çocuk çalısmaya alındı. Çocuklar yaslarına göre gruplara ayrıldı: 5-8.9, 9-11.9, ve 12-15 yıl. Çalısmaya katılan çocuklardan plazma kolesterol, trigliserid, VLDL, LDL ve HDL- kolesterol düzeyleri bakıldı. Plazma lipid düzeyleri yüksek olan çocuklardan homosistein düzeyi bakıldı. Bulgular : Ortalama plasma kolesterol, VLDL, LDL, HDL ve TG düzeyleri 142.4±26.8, 14.1±7.5, 82.8±25.6, 45.3±9.5 ve 70.8±37.7 mg/dl olarak saptandı. Total kolesterol, HDL ve LDL-C düzeyleri ile yas grupları arasında iliski saptanmazken trigliserid ve VLDL-C düzeyleri 5-8.9 yas grubunda diğer gruplara göre en düsük düzeyde saptandı. Beden kitle indeksi (BKI) ile plazma kolesterol, VLDL ve trigliserid düzeyleri arasında pozitif iliski bulundu(p<0.05,r: 0.014,r:0.117 ve r:0.121, sırası ile). Homosistein ve plazma kolesterol düzeyleri arasında pozitif korelasyon saptandı (p<0.05,r:=0.642). Ailesinde erken kardiyo ve serebro vasküler hastalık hikayesi (EFH)olan grubun ortalama plazma homosistein düzeyi olmayan gruba göre daha yüksek bulundu (p<0.05). EFH’ne etki eden faktörler multivarian lojistik regresyon analizi ile incelendiğinde hiçbir faktör etkili bulunmadı(p=0.159). Ailenin tükettiği yağ tipi ile total kolesterol, trigliserid, VLDL-C düzeyleri ve BKI arasında istatitiksel iliski saptandı (p<0.05). Sonuç: Lipit profili EFH risk faktörü tanımlanması için, obez çocuklar dısında, etkin olmayabilir. Obezite ve doymamıs yağ tüketimi kan lipid düzeyini etkileyen ve önlenebilir faktörlerdir. Böylece, yasam stili ve yemek alıskanlıkları değisiklikleri erken kardiyovasküler ve serebrovasküler hastalık gelisimini önleyebilir.

🔖

Cite This Article

SAVAR, S., TAŞAR, M., TIRAŞ, Ü., DALLAR, Y. (2008). Serum lipid levels in 5-15 years old children and affecting parameters. Ege Tıp Dergisi, Cilt: 47 - Sayı: 1, 35–45. https://ajindex.com/articles/222902

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. McGill HC Jr, McMahan CA, Herderick EE, et al. Origin of atherosclerosis in childhood and adolescence. Am J Clin Nutr 2000 Nov;72(5 Suppl):1307-15
  2. McGill HC Jr, Herderick EE, McMahan CA, et al. Atherosclerosis in youth. Minerva Pediatr 2002 Oct;54(5):437-47
  3. Hamosh M. Lipid Metabolism in Pediatric Nutriti on. Ped Clin of North Am 1995: 839-59
  4. Tokgözoğlu L. Ateroskleroz da Patoloji ve Patogenez. Türkiye Klinikleri Kardiyoloji Dergisi 2000; 13: 29–38
  5. American Academy of Pediatrics. Committee on Nutrition. Cholesterol in childhood. Pediatrics 1998 Jan;101(1 Pt 1):141-7
  6. Stanger O, Herrmann W, Pietrzik K, et al. Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases. Z Kardiol 2004 Jun;93(6):439-53
  7. De Simone M, Verroti A, Cappa M, et al. Lipoprotein (a) in childhood: correlations with family history of cardiovascular disease. J Endocrinol Invest 2003 May; 26(5): 414–9
  8. Yalçın SS, Yurdakök Y.Sağlam çocuk merkezlerinde taramalar. Katkı Pediatri Dergisi 2000; 21(2):194-213
  9. Garcia RE, Moodie DS. Routine cholesterol surveillance in childhood. Pediatrics 1989 Nov;84(5):751-5
  10. Newman T. Cholesterol Screening in Children and Adolescents. Pediatrics 2000:637-38
  11. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. U.S. Departments of Health and Human Services.NIH Publ.No.91-2732,1991 12. Gillman MW. Screening for familial hypercholesterolemia in childhood. Am J Dis Child 1993 Apr;147(4):393-6
  12. Hostetter AL. Screening for Dyslipidemia. Am J of Clin Pathol 1993;103: 380-85
  13. Wynder EL, Berenson GS, Strong WB, Williams C. Cholesterol: a pediatric perspective. Prev Med 1989;18:323-409
  14. Nicholson JF, Pesce MA. Reference ranges for labaratory tests and procedures. Behrman RE, Khegman RM, Nelson WE, Vietor C Woughan III, (eds). Nelson Textbook of Pediatrics. 17 Edt. Philadelphia: WB Sounders Company, 2004: 2181-224
  15. Ashfield-Watt PA, Moat SJ, Doshi SN, McDowell IF. Folate, homocysteine, endothelial function and cardiovascular disease. What is the link? Biomed Pharmacother 2001 Oct;55(8):425-33 17. Bas F, Günöz H. Pediatrik endokrinde kullanılan kaynak veriler. Günöz H, Öcal G, Yordam N, Kurtoğlu S (eds). Pediatrik Endokrinoloji
  16. Basım. Ankara: Pediatrik endokrinoloji ve Oksikoloji Derneği Yayınları, 2003:768-9 18. Knoflach M, Kiechl S, Kind M, et al. Cardiovascular risk factors and