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Journals / Ege Tıp Dergisi / 2016 / Cilt: 55 - Sayı: 2

Multifunctional Sox2 gene which turns out a new target in cancer

Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni

İREM DOĞAN TURAÇLI
Abdullah EKMEKÇİ
Pages
98–103
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Also, we underline its multifunctionality with discussing Sox2 gaining oncogenic properties by amplification therefore having the potential to be used as a molecular target.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sox2 protein is a transcription factor which is important for the maintenance and regulation of the permanence of undifferentiated embryonic and adult stem cells.
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Key Findings & Data:Like the other pluripotency factors, Sox2 can be regulated by posttranscriptional and post-translational modifications which affect its binding ability to DNA.
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Conclusion & Impact:Also, we underline its multifunctionality with discussing Sox2 gaining oncogenic properties by amplification therefore having the potential to be used as a molecular target.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Sox2 protein is a transcription factor which is important for the maintenance and regulation of the permanence of undifferentiated embryonic and adult stem cells. Like the other pluripotency factors, Sox2 can be regulated by posttranscriptional and post-translational modifications which affect its binding ability to DNA. Sox2 involves in many cellular events in the initiation and progression of tumorigenesis such as proliferation of cancer cells, invasion, migration, metastasis, maintenance of stem like state of cancer stem cells, cellular programming, apoptosis and chemoresistance. Although there is a confliction, it is generally accepted Sox2 is an anti-apoptotic factor in cancer cells. In this review, we discuss the roles of Sox2 in the presence of cell stemness, differantiation and signal transduction. Also, we underline its multifunctionality with discussing Sox2 gaining oncogenic properties by amplification therefore having the potential to be used as a molecular target.

Özet

Sox2 proteini, farklılaşmamış erken embriyo kök hücrelerinin ve çeşitli yetişkin kök hücrelerinin gelişimi ve devamlılığının düzenlenmesinde rol oynayan bir transkripsiyon faktörüdür. Sox2, diğer pluripotensi faktörleri gibi posttranskripsiyonel ve post-translasyonel değişimlere uğramakta, böylece DNA'ya bağlanma aktivitesi değişebilmektedir. Sox2, kanser hücrelerinin çoğalması, invazyon, göç ve metastazında, tümör hücre ve kök hücre statüsünün devamında, hücresel programlama, apoptoz ve kemodirenç gelişimi gibi pek çok kanser aşamasında yer almaktadır. Bazı farklı bulgulara karşın çoğunlukla Sox2'nin kanser hücrelerinde anti-apoptotik bir faktör olarak çalıştığı konusunda uzlaşma vardır. Bu derlemede, Sox2'nin kök hücre devamlılığı, farklılaşması ve sinyal iletimindeki rollerini, bunun yanında gen çoğalmasıyla onkojenik özelliği kazanmasını ve moleküler hedef olarak kullanılma potansiyelini de kapsayan çok yönlü özelliklerini kısaca tartışacağız.

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Cite This Article

TURAÇLI, İ. D., EKMEKÇİ, A. (2016). Multifunctional Sox2 gene which turns out a new target in cancer. Ege Tıp Dergisi, Cilt: 55 - Sayı: 2, 98–103. https://ajindex.com/articles/222716

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References (14)

  1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126(4):663-76.
  2. Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 2000;227(2):239-55.
  3. Schnitzler CE, Simmons DK, Pang K, Martindale MQ, Baxevanis AD. Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to zones of cell proliferation. Evodevo 2014;5(1):15. Sebe-Pedros A, de Mendoza A, Lang BF, Degnan BM, Ruiz-Trillo I. Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. Mol Biol Evol 2011;28(3):1241-54.
  4. Stevanovic M, Zuffardi O, Collignon J, Lovell-Badge R, Goodfellow P. The cDNA sequence and chromosomal location of the human SOX2 gene. Mamm Genome 1994;5(10):640-2. Grzybowska EA. Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing. Biochem Biophys Res Commun 2012;424(1):1-6.
  5. Fantes J, Ragge NK, Lynch SA, et al. Mutations in SOX2 cause anophthalmia. Nat Genet 2003;33(4):461-3.
  6. Amaral PP, Neyt C, Wilkins SJ, et al. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA 2009;15(11):2013-27.
  7. Shahryari A, Rafiee MR, Fouani Y, et al. Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and Oct4 in esophageal squamous cell carcinoma. Stem Cells 2014;32(1):126-34.
  8. Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001;291(5507):1304-51.
  9. Markovic D, Challiss RA. Alternative splicing of G protein-coupled receptors: physiology and pathophysiology. Cell Mol Life Sci 2009;66(20):3337-52.
  10. Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007;7(2):79-94.
  11. Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990;346(6281):240-4.
  12. Schepers GE, Teasdale RD, Koopman P. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 2002;3(2):167-70.
  13. Kamachi Y, Uchikawa M, Kondoh H. Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet 2000;16(4):182-7.
  14. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.