Journals / Ege Tıp Dergisi / 2020 / Cilt: 59 - Sayı: 1

Targeting of metallic nanoparticles

Metalik nanopartiküllerin hedeflendirilmesi

Pages
71–81
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this review is summarize the properties, classification and use of metal nanoparticles and discuss the use of metallic nanoparticles as drug delivery systems in the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of targeted drug delivery systems are increase therapeutic efficacy, improve drug localization, provide controlled release of the active substance and decrease drug toxicity.
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Key Findings & Data:In this respect, metallic nanoparticles provide a new dimension in the achievement of these aims in the treatment of several diseases and the simplicity and ease of preparation of these particles have attracted the attention of the scientific community.
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Conclusion & Impact:The aim of this review is summarize the properties, classification and use of metal nanoparticles and discuss the use of metallic nanoparticles as drug delivery systems in the literature.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of targeted drug delivery systems are increase therapeutic efficacy, improve drug localization, provide controlled release of the active substance and decrease drug toxicity. In this respect, metallic nanoparticles provide a new dimension in the achievement of these aims in the treatment of several diseases and the simplicity and ease of preparation of these particles have attracted the attention of the scientific community. The aim of this review is summarize the properties, classification and use of metal nanoparticles and discuss the use of metallic nanoparticles as drug delivery systems in the literature.

Özet

HedeflendirilmiĢ ilaç taĢıyıcı sistemlerin amacı, terapötik etkinliği arttırmak, etkin maddenin kontrollü salımını sağlamayı, ilaç lokalizasyonunu iyileĢtirmeyi ve ilaç toksisitesini azaltmayı amaçlamaktadır. Bu bakımdan, metalik nanopartiküller, çeĢitli hastalıkların tedavisinde bu amaçların yerine getirilmesinde yeni bir boyut sunar ve bu partiküllerin sadeliği ve hazırlanma kolaylığı, bilim dünyasının ilgisine neden olmuĢtur. Bu derlemenin amacı, metal nanopartiküllerin özelliklerini, sınıflandırılmalarını ve hedeflendirilmiĢ ilaç taĢımada kullanımını özetlenmesi ve metalik nanopartiküllerin ilaç taĢıyıcı sistem olarak kullanımının literatür eĢliğinde tartıĢılmasıdır.

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Cite This Article

UYANİKGİL, E. O. C., SALMANOĞLU, D. S. (2020). Targeting of metallic nanoparticles. Ege Tıp Dergisi, Cilt: 59 - Sayı: 1, 71–81. https://ajindex.com/articles/222665

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References (15)

  1. Kang YS, Risbud S, Rabolt JF, Stroeve P. Synthesis and characterization of nanometer-size Fe3O4 and γFe2O3 particles. Chem Mater. 1996
  2. 2209–11. 2.Pankhurst QA, Connolly J, Jones S, Dobson J. Applications of magnetic nanoparticles in biomedicine. Journal of physics D: Applied physics. 2003
  3. R167. 3.Dobson J. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery. Gene Ther. 2006
  4. 283–7. 4.Rudge S, Peterson C, Vessely C, Koda J, Stevens S, Catterall L. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). J Control Release. 2001
  5. 335–40. 5.Appenzeller T. The man who dared to think small. Science. 1991
  6. Frank G, Langer R, Farokhzad OC. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block coploymers. PNAS 2008
  7. 105 (7): 2586. 7.Chouhan R, Bajpai AK. Real time in vitro studies of doxorubicin release from PHEMA nanoparticles. J Nanobiotechnology 2009
  8. 7 (5): 7. 8.Gelperina S, Kisich K, Iseman MD, Heifets L. The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am J RespirCrit Care Med. 2005
  9. 172 (12): 1487-90. 9.Susa M, Iyer AK, Ryu K, Hornicek FJ, Mankin H, Amiji MM, Duan Z. Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. BMCCancer 2009
  10. Sajja HK, East MP, Mao H, Wang YA, Nie S, Yang L. Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect. CurrDrugDiscovTechnol 2009
  11. Varshosaz J, Farzan M. Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma. World J Gastroenterol 2015
  12. 21 (42): 12022-41. 12.Coelho SM. Delivery of biomolecules by functionalized inorganic/organic nanoparticles thesis silvia. Thesis submitted to the University of Porto for a Doctor of Philosophy in Chemical and Biological Engineering. 2013. 13.Selvan ST, Tan TTY, Yi DK, et al. Functional and multifunctional nanoparticles for bioimaging and biosensing. Langmuir. 2010
  13. 11631–41. 14.Baptista P, Pereira E, Eaton P, Doria G, Miranda A, Gomes I et al. Gold nanoparticles for the development of clinical diagnosis methods. Anal BioanalChem. 2008
  14. 943–50. 15.Hainfeld JF, Dilmanian FA, Slatkin DN, Smilowitz HM. Radiotherapy enhancement with gold nanoparticles. J PharmPharmacol. 2008
  15. 977–85. 16.Mody VV, Siwale R, Singh A