SavedAdd your journal

Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2010 / Cilt: 23 - Sayı: 3

Leucopenia due to quetiapine abuse and combination with olanzapine: A case report

Ketiapin kötüye kullanımı ve olanzapin ile kombinasyonu sonucu gelişen lökopeni: Bir olgu sunumu

Erkan AYDIN
ÖMER ŞENORMANCI
Kürşat ALTINBAŞ
Erhan KURT
Pages
219–222
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Blood levels returned to normal levels in a short period of time both by passing to extended release quetiapine and decreasing the daily dosage.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Quetiapine is an atypical antipsychotic that can be abused.
📊
Key Findings & Data:Olanzapine is an another atypical antipsychotic that is similar to quetiapine in chemical structure and cases of leucopenia after olanzapine use have rarely been presented in the literature.
💡
Conclusion & Impact:Blood levels returned to normal levels in a short period of time both by passing to extended release quetiapine and decreasing the daily dosage.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Quetiapine is an atypical antipsychotic that can be abused. Olanzapine is an another atypical antipsychotic that is similar to quetiapine in chemical structure and cases of leucopenia after olanzapine use have rarely been presented in the literature. In this report, we presented a case of high dose quetiapine abuse and olanzapine combination treatment leading to leucopenia. Blood levels returned to normal levels in a short period of time both by passing to extended release quetiapine and decreasing the daily dosage.

Özet

Ketiapin, kötüye kullanım potansiyeli taşıyan atipik bir antipsikotiktir. Olanzapin ise, yapıca ketiapine benzeyen ve literatürde nadiren lökopeniye neden olduğu bildirilmiş bir atipik antipsikotiktir. Burada, yüksek doz ketiapin kötüye kullanımı ve eş zamanlı olanzapin kullanımı sonucu lökopeni gelişen, ketiapinin uzun salınımlı formuna geçiş yapılarak ilaç dozlarının düşürülmesi neticesinde kısa zamanda kan değerleri düzelen bir olgu sunulmuştur.

🔖

Cite This Article

AYDIN, E., ŞENORMANCI, Ö., ALTINBAŞ, K., KURT, E. (2010). Leucopenia due to quetiapine abuse and combination with olanzapine: A case report. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 23 - Sayı: 3, 219–222. https://ajindex.com/articles/222541

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Stahl SM. Stahl’s Essential Psychopharmacology: The Prescriber’s Guide. Revised and Updated ed., Cambridge: Cambridge University Press, 2006; 427
  2. Sattar SP, Bhatia SC, Petty F. Potential benefits of quetiapine in the treatment of substance dependence disorders. J Psychiatry Neurosci 2004; 29:452-457
  3. Martinotti G, Andreoli S, Di Nicola M, Di Giannantonio M, Sarchiapone M. Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholics. Hum Psychopharmacol 2008; 23:417-424
  4. Croissant B, Klein O, Gehrlein L, Kniest A, Hermann D, Diehl A, Mann K. Quetiapine in relapse prevention in alcoholics suffering from craving and affective symptoms: a case series. Eur Psychiatry 2006; 21:570-573
  5. Evren C, Karatepe HT, Aydın A, Dalbudak E, Cakmak D. Alkol/ madde bağımlılarında ketiapinin etkisi ve kötüye kullanımı: Olgu serisi ve gözden geçirme. Klinik Psikofarmakoloji Bülteni 2009; 19:148-154
  6. Altıntoprak AE, Ünal E, Bayrakçı A, Gülseren Ş, Coşkunol H. Ketiapin bağımlılık mı yapıyor? Anadolu Psikiyatri Dergisi 2010; 11:76-78
  7. Pierre JM, Shnayder I, Wirshing DA, Wirshing WC. Intranasal quetiapine abuse. Am J Psychiatry 2004; 161:1718
  8. Hussain MZ, Waheed W, Hussain S. Intravenous quetiapine abuse. Am J Psychiatry 2005; 162:1755-1756
  9. Kim DR, Staab JP. Quetiapine discontinuation syndrome. Am J Psychiatry. 2005; 162:1020
  10. Pinta ER, Taylor RE. Quetiapine addiction? Am J Psychiatry. 2007; 164:174-175
  11. Su JA, Wu CH, Tsang HY. Olanzapine-induced agranulocytosis in systemic lupus erythematosus: a case report. Gen Hosp Psychiatry. 2007; 29:75-77
  12. Stip E, Langlois R, Thuot C, Mancini-Marïe A. Fatal agranulocytosis: the use of olanzapine in a patient with schizophrenia and myelodysplasia. Prog Neuropsychopharmacol Biol Psychiatry 2007: 30;31:297-300
  13. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, Fourth ed. Text revision (DSM-IVTR). Washington: American Psychiatric Association, 2000
  14. Figueroa C, Brecher M, Hamer-Maansson JE, Winter H. Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release. Prog Neuropsychopharmacol Biol Psychiatry 2009: 17;33:199-204
  15. Shankar BR. Quetiapine-induced leucopenia and thrombocytopenia. Psychosomatics 2007; 48:530-531
  16. Nair P, Lippmann S. Is leukopenia associated with divalproex and/or quetiapine? Psychosomatics 2005: 46:188-189
  17. Post RM, Roy-Byrne PP, Uhde TW