Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2008 / Cilt: 22 - Sayı: 2

Ischemia reperfusion and cancer metastasis: Biochemical aspects

İskemi-reperfüzyon ve kanser metastazı: Biyokimyasal bakış

Pages
89–98
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, from the points of biochemical view, we aimed to explain relationships between ischemia-reperfusion and tumor metastasis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ischemia and reperfusion is a complex reaction that plays important roles on initial periods of various patophysiologic processes in human organism.
📊
Key Findings & Data:There are also some links between ischemia-reperfusion and tumor metastasis.
💡
Conclusion & Impact:In this article, from the points of biochemical view, we aimed to explain relationships between ischemia-reperfusion and tumor metastasis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Ischemia and reperfusion is a complex reaction that plays important roles on initial periods of various patophysiologic processes in human organism. There are also some links between ischemia-reperfusion and tumor metastasis. However, this topic is still unclear. In this article, from the points of biochemical view, we aimed to explain relationships between ischemia-reperfusion and tumor metastasis.

Özet

İskemi-reperfüzyon insan organizmasında pek çok patofizyolojik sürecin başlangıcında önemli rol alan karmaşık bir reaksiyondur. Iskemi-reperfuzyon ile tumor metastazi arasında da ilişkiler mevcuttur. Ancak bu konu yeterince aydınlatılamamıştır. Bu yazıda iskemi-reperfüzyon olayı ile kanser metastazı arasındaki ilişkilerin biyokimyasal pencereden açıklanması hedeflenmiştir.

🔖

Cite This Article

ÖZKAYA, F. C., KOÇDOR, H. (2008). Ischemia reperfusion and cancer metastasis: Biochemical aspects. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 22 - Sayı: 2, 89–98. https://ajindex.com/articles/222362

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Siemionow M, Arslan E. Ischemia/reperfusion injury: A review in relation to free tissue transfers. Microsurgery 2004;24: 468-475
  2. Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165–175
  3. Carden DL, Granger DN. Pathophysiology of ischemiareperfusion injury. J Pathol, 2000;190: 255–266
  4. Manson PN, Anthenelli RM, Im MJ, Bulkley GB, Hoopes JE. The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann Surg 1983;198:87–90
  5. Knight KR, Angel MF, Lepore DA et al. Secondary ischaemia in rabbit skin flaps: the roles played by thromboxane and free radicals. Clin Sci 1991;80:235–240
  6. Morris SF, Pang CY, Zhong A, Boyd B, Forrest CR. Assessment of ischemia-induced reperfusion injury in the pig latissimus dorsi myocutaneous flap model. Plast Reconstr Surg 1993;92:1162–1172
  7. İşlekel H, İşlekel S, Güner G. Biochemical Mechanism and Tissue Injury of Cerebral Ischemia and Reperfusion Part II: Tissue Injury. Journal of Neurological Sciences (Turkish). Norol Bil D 2000;17: 2
  8. Simon RJ Maxwell, Gregory YH Lip. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. International Journal of Cardiology 1997;58:95–117
  9. Fouad Amr A, El-Rehany M, Abdel-Aziz, Maghraby HK. The hepatoprotective effect of carnosine against ischemia/ reperfusion liver injury in rats. European Journal of Pharmacology 2007, 572:61-68
  10. Doi K, Horiuchi T, Uchinami M et al. Hepatic Ischemia– Reperfusion Promotes Liver Metastasis of Colon Cancer. J Surg Res 2002;15:243-247
  11. Moon B-K, Lee YJ, Battle P, Jessup JM, Raz A, Kim H-R C. Galectin–3 Protects Human Breast Carcinoma Cells against Nitric Oxide-Induced Apoptosis. American Journal of Pathology 2001; 59: 1055-1060
  12. Shirahane K, Yamaguchi K, Koga K, Watanabe M, Kuroki S, Tanaka M. Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817. Surgery 2006;139:653–664
  13. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 2000;18:1135–1149
  14. Nelson KK, Melendez JA. Mitochondrial Redox Control Of Matrix Metalloproteinases. Free Rad Biol & Med 2004; 37:768 -784
  15. Murray GI, Duncan ME, Arbuckle E, Melvin WT, Fothergill JE. Matrix metalloproteinases and their inhibitors in gastric cancer. Gut 1998;43:791- 797
  16. Remacle AG, Noel A, Duggan Cet al. Assay of matrix metalloproteinases