Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2019 / Cilt: 33 - Sayı: 3

STEM CELLS

Kök Hücreler

Pages
271–280
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, the definition, common characteristics, and clinical use of different stem cells will be discussed.

📌 3 Key Takeaways

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Objective & Hypothesis:A stem cell is an undifferentiated cell that can self-renew itself and can commit to a specific cell type.
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Key Findings & Data:Depending on their residency, stem cells are classified into two main categories as embryonic stem cells and adult stem cells.
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Conclusion & Impact:In this review, the definition, common characteristics, and clinical use of different stem cells will be discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:kök hücre · embriyonik kök hücre · indüklenmiş pluripotent kök hücre

Abstract

A stem cell is an undifferentiated cell that can self-renew itself and can commit to a specific cell type. Depending on their residency, stem cells are classified into two main categories as embryonic stem cells and adult stem cells. According to their differentiation and developmental potential, stem cells may be classified as totipotent, pluripotent, multipotent, and unipotent. The therapeutic potential in disease states and in regenerative medicine of embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, hematopoietic stem cells, and cancer stem cells have been studied in different scientific areas. In this review, the definition, common characteristics, and clinical use of different stem cells will be discussed.

Özet

Kök hücreler kendini yenileyebilen ve spesifik hücre tiplerine dönüşebilen farklılaşmamış hücrelerdir. Kök hücreler vücutta bulundukları yere göre başlıca embriyonik kök hücreler ve erişkin kök hücreler olarak iki ana sınıfa ayrılır. Farklılaşma ve gelişme potansiyellerine göre ise kök hücreler totipotent, pluripotent, multipotent, oligopotent veya unipotent olabilirler. Çeşitli hastalıklarda tedavi amacıyla kullanılabilme ve rejeneratif tıptaki potansiyelleri nedeniyle embriyonik kök hücreler, indüklenmiş pluripotent kök hücreler, mezenkimal kök hücreler, hematopoietik kök hücreler ve kanser kök hücreleri ile farklı bilim alanlarında yapılmış çalışmalar vardır. Bu yazıda kök hücre tanımı, genel özellikleri ve klinikteki kullanımları üzerinde durulacaktır.

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Cite This Article

ÖREN, H. (2019). STEM CELLS. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 33 - Sayı: 3, 271–280. https://ajindex.com/articles/222347

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References (17)

  1. Schöler HR. The Potential of Stem Cells: An Inventory. In: Knoepffler N, Schipanski D, Sorgner SL ed. Humanbiotechnology as Social Challenge. London: Ashgate Publishing, 2007
  2. Can A. Kök Hücre. In: Can A, ed. Kök Hücre Biyolojisi, Türleri ve Klinik Kullanımları. Ankara: Akademisyen Tıp Kitabevi, 2014
  3. Can A. Kök hücrelerin genel özellikleri, embriyonik veee yetişkin kök hücrelere genel bakış. Hematolog 2014;4:238-254
  4. Avcılar H, Saraymen B, Özturan OÖ, Köker MY. Embriyonik kök hücreler ve indüklenmiş pluripotent kök hücreler. Asthma Allergy Immunol 2018;16:1-10
  5. Dulak J, Szade K, Szade A, Nowak W, Józkowicz A. Adult stem cells: hopes and hypes of regenerative medicine. Acta Biochim Pol 2015;62:329-337
  6. Shinin V, Gayraud-Morel B, Gomès D, Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol 2006;8:677-687
  7. Kiraz Y, Ünlü M, Yandım MK, Baran Y. Kök hücrelerin moleküler biyolojisi. Hematolog 2014;4:255-265
  8. Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, et al. Human embryonic stem cells derived bysomatic cell nuclear transfer. Cell 2013;153:1228-1238
  9. Daughtry B, Mitalipov S. Concise review: Parthenote stem cells for regenerative medicine: Genetic, epigenetic, and developmental features. Stem Cells Transl Med 2014;3:290-8
  10. Blum B, Benvenisty N. The tumorigenicity of human embryonic stem cells. Adv Cancer Res 2008;100:133-158
  11. Unger C, Skottman H, Blomberg P, Dilber MS, Hovatta O. Good manufacturing practice and clinical-grade human embryonic stem cell lines. Hum Mol Genet 2008;17:48-53
  12. Kozan S, Öztuna A. İndüklenmiş pluripotent kök hücrelerin genel özellikleri ve temel kavramlar. Hematolog 2014;4:351-364
  13. Ebben D, Zorniak M, Clark PA, Kuo JS. Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine. World Neurosurg 2011;76:270-275
  14. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676
  15. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872
  16. Gurdon JB, Elsdale TR, Fischberg M. Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 1958;182:64-65
  17. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Vi