SavedAdd your journal

Journals / Turkish Journal of Chemistry / 2006 / Cilt: 30 - Sayı: 2

Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7- Methyl-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities

Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7-Methyl-4-Oxo- 1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities

Sajjad AHMED
Moazzam Hussain BHATTI
Saqib ALI
Pages
193–202
Publication Date
2006-02-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These compounds were also screened for their antifungal and antibacterial activities.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Organotin carboxylates of the general formulae R2SnL2 and R3SnL, where R = CH3, n-C4H9, C6H5, CH2C6H5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), have been prepared.
📊
Key Findings & Data:These compounds were characterized by FT-IR, mass and multinuclear NMR (1H, 13C and 119Sn) spectroscopy.
💡
Conclusion & Impact:These compounds were also screened for their antifungal and antibacterial activities.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Organotin(IV) complexes · 1-ethyl-1 · 4-dihydro-7-methyl-4-oxo-1

Abstract

Organotin carboxylates of the general formulae R2SnL2 and R3SnL, where R = CH3, n-C4H9, C6H5, CH2C6H5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), have been prepared. These compounds were characterized by FT-IR, mass and multinuclear NMR (1H, 13C and 119Sn) spectroscopy. The geometry around the tin atom is compared both in solution and in solid state. These compounds were also screened for their antifungal and antibacterial activities.

Özet

Organotin carboxylates of the general formulae R2SnL2 and R3SnL, where R = CH3, n-C4H9, C6H5, CH2C6H5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), have been prepared. These compounds were characterized by FT-IR, mass and multinuclear NMR (1H, 13C and 119Sn) spectroscopy. The geometry around the tin atom is compared both in solution and in solid state. These compounds were also screened for their antifungal and antibacterial activities.

🔖

Cite This Article

AHMED, S., BHATTI, M. H., ALI, S. (2006). Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7- Methyl-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities. Turkish Journal of Chemistry, Cilt: 30 - Sayı: 2, 193–202. https://ajindex.com/articles/220570

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (21)

  1. M. Nath, S. Pokharia and R. Yadav, Coord. Chem. Rev., 215, 99 (2001).
  2. V. Chandrasekhar, S. Nagendran and V. Baskar, Coord. Chem. Rev., 235, 1 (2002).
  3. M. Mazhar, M.A. Choudhary, S. Ali, X.Q. Lan and S. Xueqing, J. Chem. Soc. Pak., 23, 103 (2001).
  4. M. Gielen, Appl. Organomet. Chem., 16, 481 (2002).
  5. S.J. Blunden, P.A. Cussack and R. Hill, “The Industrial Uses of Tin Compounds”. Royal Society of Chemistry, London, 1985.
  6. E.R.T. Tiekink, J. Organomet. Chem., 1, 71 (1994).
  7. S. Mahmood, S. Ali, M.H. Bhatti, M. Mazhar, K. Shahid, K.M. Khan and G.M. Maharvi, Turk. J. Chem.,, 17 (2004).
  8. S. Ahmed, S. Ali, F. Ahmad, M.H. Bhatti, A. Badshah, M. Mazhar and K.M. Khan, Synth. React. Inorg. Met.-Org. Chem., 32, 1521 (2002).
  9. S. Ali, M.N. Khokhar, M.H. Bhatti, M. Mazhar M.T. Masood, K. Shahid and A. Badshah, Synth. React. Inorg. Met.-Org. Chem., 32, 1373 (2002).
  10. M.H. Bhatti, S. Ali, H. Masood, M. Mazhar and S.I. Qureshi, Synth. React. Inorg. Met. -Org. Chem.,, 1715 (2000).
  11. M. Parvez, S. Ahmed, S. Ali, M.H. Bhatti and M. Mazhar, Acta Cryst. E60, m554 (2004).
  12. M. Parvez, M.H. Bhatti, S. Ali, M. Mazhar and S.I. Qureshi, Acta Cryst., C56, 327 (2000).
  13. M. Danish, H.G. Alt, A. Badshah, S. Ali, M. Mazhar and N. Islam, J. Organomet. Chem., 486, 51 (1995).
  14. S. Xueqing, X. Qinglan and F. Xiaoniu, Heteroatom Chem., 13, 592 (2002).
  15. S. Xueqing, Y. Zhiqiang, X. Qinglan and Li. Jinshan, J. Organomet. Chem., 566, 103 (1998).
  16. M. Danish, S. Ali, M. Mazhar, A. Badshah, M.I. Chaudhry, H.G. Alt and G. Kehr, Polyhedron, 14, 3115 (1995).
  17. C.C. Camacho, D. de Vos, B. Mahieu, M. Gielen, M. Kemmer, M. Biesemans and R. Willem, Main Group Met. Chem., 23, 381 (2000).
  18. F. Ahmad, S. Ali, M. Parvez, A. Munir, M. Mazhar, K.M. Khan and T.A. Shah, Heteroatom Chem., 13, (2002).
  19. A. Rahman, M.I. Choudhary and W.J. Thomsen, “Bioassay Techniques for Drug Development”; Har- wood Academic Publishers: The Netherlands, 2001. K.C. Molloy,“Bio Organotin compounds”. in the Chemistry of Metal-Carbon Bond. Hartley, F.R. (Ed.); Wiley: New York, 1989.
  20. B.N. Meyer, N.R. Ferrigni, J.E. Putman, L.B. Jacobson, D.E. Nicholas and J.L. McLaughlin, Planta Medica., 31 (1982).
  21. K. Sisido, Y. Takeda and Z. Kingawa, J. Am. Chem. Soc., 83, 538 (1961).