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Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2019 / Cilt: 32 - Sayı: 3

Rechallenge of clozapine in a patient with a history of clozapine-induced myocarditis

Buket KOPARAL
Melike KÜÇÜKKARAPINAR
İrem EKMEKÇİ ERTEK
Pages
275–278
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It may be possible to use clozapine even after myocarditis and thus improve symptoms and functionality of schizophrenia patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Clozapine is the only antipsychotic with proven efficacy in treatment-resistant schizophrenia, but some life-threatening side effects limit its use.
📊
Key Findings & Data:The patient still uses clozapine and has not developed myocarditis over 36 months of observation.
💡
Conclusion & Impact:It may be possible to use clozapine even after myocarditis and thus improve symptoms and functionality of schizophrenia patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Clozapine is the only antipsychotic with proven efficacy in treatment-resistant schizophrenia, but some life-threatening side effects limit its use. Here we report a patient with clozapine-induced myocarditis and successful rechallenge. The patient still uses clozapine and has not developed myocarditis over 36 months of observation. It may be possible to use clozapine even after myocarditis and thus improve symptoms and functionality of schizophrenia patients.

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Cite This Article

KOPARAL, B., KÜÇÜKKARAPINAR, M., ERTEK, İ. E. (2019). Rechallenge of clozapine in a patient with a history of clozapine-induced myocarditis. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 32 - Sayı: 3, 275–278. https://ajindex.com/articles/217731

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References (10)

  1. De Berardis D, Serroni N, Campanella D, Olivieri L, Ferri F, Carano A, Cavuto M, Martinotti G, Cicconetti A, Piersanti M, Saverio Moschetta F, Di Giannantonio M. Update on the adverse effects of clozapine: focus on myocarditis. Curr Drug Saf 2012; 7:55-62.
  2. Datta T, Solomon AJ. Clozapine-induced myocarditis. Oxf Med Case Reports 2018; 2018:omx080. Magnani JW, Dec JW. Myocarditis: Current Trends in Diagnosis and Treatment. Circulation 2006; 113:876-890.
  3. Elman I, Goldstein DS, Eisenhofer G, Folio J, Malhotra AK, Adler CM, Pickar D, Breier A. Mechanism of peripheral noradrenergic stimulation by clozapine. Neuropsychopharmacology 1999; 20:29-34.
  4. Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, Wolfe R, McNeil JJ. Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: A case-control study. Schizophr Res 2012; 141:173- 178. Devarajan S, Kutcher SP, Dursun SM. Clozapine and sudden death. Lancet 2000; 355:841; author reply 843. Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, McNeil JJ. Clinical course and analysis of ten fatal cases of clozapineinduced myocarditis and comparison with 66 surviving cases. Schizophr Res 2011; 128:161-165.
  5. Chow V, Feijo I, Trieu J, Starling J, Kritharides L. Successful rechallenge of clozapine therapy following previous clozapineinduced myocarditis confirmed on cardiac MRI. J Child Adolesc Psychopharmacol 2014; 24:99-101.
  6. Rosenfeld AJ, Gibbs T, Ivie R, Clarke L, Merrill DB. Successful clozapine retrial after suspected myocarditis. Am J Psychiatry 2010; 167:350-351.
  7. Bray A, Reid R. Successful clozapine rechallenge after acute myocarditis. Aust N Z J Psychiatry 2011; 45:90. Reinders J, Parsonage W, Lange D, Potter JM, Plever S. Clozapinerelated myocarditis and cardiomyopathy in an Australian metropolitan psychiatric service. Aust N Z J Psychiatry 2004; 38:915-922.
  8. Ronaldson KJ, Fitzgerald PB, Taylor AJ, Topliss DJ, McNeil JJ. A New Monitoring Protocol for Clozapine-Induced Myocarditis Based on an Analysis of 75 Cases and 94 Controls. Aust N Z J Psychiatry 2011; 45:458-465.
  9. Otsuka Y, Idemoto K, Hosoda Y, Imamura Y, Aoki T. Clozapineinduced myocarditis: follow-up for 3.5 years after successful retrial. J Gen Fam Med 2019; 20:114-117.
  10. Ittasakul P, Archer A, Kezman J, Atsariyasing W, Goldman MB. Rapid rechallenge with clozapine following pronounced myocarditis in a treatment-resistant schizophrenia patient. Clin Schizophr Relat Psychoses 2016; 10:120-122.